TLC Retention Behavior of Brodifacoum, Bromadiolone, and Coumatetralyl and their Impurities on Different Adsorbents
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2009
Authors
Tosti, Tomislav
Rakić, Gordana
Natić, Maja

Milojković-Opsenica, Dušanka

Husinec, Suren
Savić, Vladimir

Tešić, Živoslav

Article (Published version)

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Show full item recordAbstract
The chromatographic behavior of three biocidal technical materials, rodenticide active ingredients brodifacoum, bromadiolone, and coumatetralyl, and impurities present in the technical material was investigated by both normal-phase (NP) and reversed-phase (RP) planar chromatography. The research was carried out using thin-layers of silica gel, alumina, cellulose, and C-18 silica. Several solvents on their own or in various combinations and proportions were used for separation. The optimum chromatographic systems for separation of the substances from each other and from their impurities were selected. Under reversed-phase chromatographic (RPC) conditions a linear correlation between R-M values and mobile phase composition was established. From results obtained, the lipophilicity R-M(o) and C-0 were determined. Possible separation mechanisms are discussed on the basis of the established retention behavior.
Keywords:
Brodifacoum / Bromadiolone / Coumatetralyl / LipophilicitySource:
Journal of Planar Chromatography - Modern TLC, 2009, 22, 5, 333-343Publisher:
- Akademiai Kiado Zrt, Budapest
Projects:
- Sinteza, analiza i aktivnost novih organskih polidentatnih liganada i njihovih kompleksa sa d-metalima (RS-142062)
DOI: 10.1556/JPC.22.2009.5.4
ISSN: 0933-4173