Annulations of isoquinoline and beta-carboline ring systems: synthesis of 8-oxoprotoberberine derivatives
Samo za registrovane korisnike
2011
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Annulation processes of isoquinoline and p-carboline compounds have been investigated leading to synthetic routes for the preparation of 8-oxoprotoberberine derivatives. The key steps combined a diene formation/Diels-Alder cycloaddition reaction to afford the targeted polycyclic skeletons. Further oxidative transformations of the cycloadducts produced the 8-oxoprotoberberine type products. The alkaloids of this class are important natural products with a wide range of biological activity and the synthethic methodology described in this paper could prove to be useful for the preparation of the D-ring functionalised derivatives.
Ključne reči:
Isoquinoline / Annulations / 8-Oxoprotoberberine skeletons / SynthesisIzvor:
Tetrahedron Letters, 2011, 52, 21, 2733-2736Izdavač:
- Oxford : Pergamon-Elsevier Science Ltd
Finansiranje / projekti:
- Kompjutersko dizajniranje, sinteza i biološka evaluacija novih heterocikličnih jedinjenja kao selektivnih inhibitora tumorogeneze (RS-172009)
- NTU (SPMS)
- NTU (CBC)
DOI: 10.1016/j.tetlet.2011.03.085
ISSN: 0040-4039
WoS: 000290602100030
Scopus: 2-s2.0-79955483488
URI
http://cherry.chem.bg.ac.rs/handle/123456789/1342https://cer.ihtm.bg.ac.rs/handle/123456789/3505
http://farfar.pharmacy.bg.ac.rs/handle/123456789/1567
Institucija/grupa
IHTMTY - JOUR AU - Husinec, Suren AU - Savić, Vladimir AU - Simić, Milena R. AU - Tešević, Vele AU - Vidović, Dragoslav PY - 2011 UR - http://cherry.chem.bg.ac.rs/handle/123456789/1342 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/3505 UR - http://farfar.pharmacy.bg.ac.rs/handle/123456789/1567 AB - Annulation processes of isoquinoline and p-carboline compounds have been investigated leading to synthetic routes for the preparation of 8-oxoprotoberberine derivatives. The key steps combined a diene formation/Diels-Alder cycloaddition reaction to afford the targeted polycyclic skeletons. Further oxidative transformations of the cycloadducts produced the 8-oxoprotoberberine type products. The alkaloids of this class are important natural products with a wide range of biological activity and the synthethic methodology described in this paper could prove to be useful for the preparation of the D-ring functionalised derivatives. PB - Oxford : Pergamon-Elsevier Science Ltd T2 - Tetrahedron Letters T1 - Annulations of isoquinoline and beta-carboline ring systems: synthesis of 8-oxoprotoberberine derivatives VL - 52 IS - 21 SP - 2733 EP - 2736 DO - 10.1016/j.tetlet.2011.03.085 ER -
@article{ author = "Husinec, Suren and Savić, Vladimir and Simić, Milena R. and Tešević, Vele and Vidović, Dragoslav", year = "2011", abstract = "Annulation processes of isoquinoline and p-carboline compounds have been investigated leading to synthetic routes for the preparation of 8-oxoprotoberberine derivatives. The key steps combined a diene formation/Diels-Alder cycloaddition reaction to afford the targeted polycyclic skeletons. Further oxidative transformations of the cycloadducts produced the 8-oxoprotoberberine type products. The alkaloids of this class are important natural products with a wide range of biological activity and the synthethic methodology described in this paper could prove to be useful for the preparation of the D-ring functionalised derivatives.", publisher = "Oxford : Pergamon-Elsevier Science Ltd", journal = "Tetrahedron Letters", title = "Annulations of isoquinoline and beta-carboline ring systems: synthesis of 8-oxoprotoberberine derivatives", volume = "52", number = "21", pages = "2733-2736", doi = "10.1016/j.tetlet.2011.03.085" }
Husinec, S., Savić, V., Simić, M. R., Tešević, V.,& Vidović, D.. (2011). Annulations of isoquinoline and beta-carboline ring systems: synthesis of 8-oxoprotoberberine derivatives. in Tetrahedron Letters Oxford : Pergamon-Elsevier Science Ltd., 52(21), 2733-2736. https://doi.org/10.1016/j.tetlet.2011.03.085
Husinec S, Savić V, Simić MR, Tešević V, Vidović D. Annulations of isoquinoline and beta-carboline ring systems: synthesis of 8-oxoprotoberberine derivatives. in Tetrahedron Letters. 2011;52(21):2733-2736. doi:10.1016/j.tetlet.2011.03.085 .
Husinec, Suren, Savić, Vladimir, Simić, Milena R., Tešević, Vele, Vidović, Dragoslav, "Annulations of isoquinoline and beta-carboline ring systems: synthesis of 8-oxoprotoberberine derivatives" in Tetrahedron Letters, 52, no. 21 (2011):2733-2736, https://doi.org/10.1016/j.tetlet.2011.03.085 . .