Effects of fullerene C60 supplementation on gut microbiota and glucose and lipid homeostasis in rats
Authorized Users Only
2020
Authors
Đurašević, Siniša
Nikolić, Gorana
Todorović, Ana

Drakulić, Dunja

Pejić, Snežana

Martinović, Vesna

Mitić-Ćulafić, Dragana

Milić, Dragana

Kop, Tatjana

Jasnić, Nebojša

Đorđević, Jelena

Todorović, Zoran

Article (Published version)

Elsevier
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The effects of twelve weeks of supplementation with fullerene C60 olive/coconut oil solution on a broad spectrum of parameters in rats were examined. The tissue bioaccumulation of C60 was shown to be tissue-specific, with the liver, heart, and adrenal glands being the organs of the greatest, and the kidney, brain, and spleen being the organs of the smallest accumulation. C60 did not change aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase serum activities level, nor the damage of liver cells DNA. There were no effects of fullerene on prooxidant-antioxidant balance in the liver, kidney, spleen, heart, and brain, nor any visible harmful effects on the liver, heart, aorta, spleen, kidney, and small intestine histology. Fullerene changed the gut microbiota structure towards the bacteria that ameliorate lipid homeostasis, causing a serum triglycerides concentration decrease. However, C60 significantly increased the insulin resistance, serum ascorbate oxidation, ...and brain malondialdehyde and advanced oxidation protein products level. The deteriorative effects of C60 on the brain and serum could be attributed to the specific physicochemical composition of these tissues, potentiating the C60 aggregation or biotransformation as the key element of its pro-oxidative action.
Keywords:
Fullerene C60 / Glucose homeostasis / Lipid homeostasis / Gut microbiota / RatsSource:
Food and Chemical Toxicology, 2020, 140, 111322-Publisher:
- Elsevier
Funding / projects:
- Effects of metabolic and nonmetabolic stressors on the expression and action of neuroendocrine regulators of energy homeostasis (RS-173023)
- Signaling molecules in diabetes: search for potential targets in intrinsic pathways for prediction and intervention in diabetes (RS-173020)
- Design, synthesis and investigations of fullerene based nanomolecular machines (RS-172002)
- Bioactive natural products as potential sources of new pharmaceuticals and food supplements (RS-172058)
- Cellular and molecular basis of malignant and cardiovascular diseases-clinical implications (RS-41027)
DOI: 10.1016/j.fct.2020.111302
ISSN: 0278-6915
WoS: 000535895100014
Scopus: 2-s2.0-85082680875
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Institution/Community
IHTMTY - JOUR AU - Đurašević, Siniša AU - Nikolić, Gorana AU - Todorović, Ana AU - Drakulić, Dunja AU - Pejić, Snežana AU - Martinović, Vesna AU - Mitić-Ćulafić, Dragana AU - Milić, Dragana AU - Kop, Tatjana AU - Jasnić, Nebojša AU - Đorđević, Jelena AU - Todorović, Zoran PY - 2020 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/3488 AB - The effects of twelve weeks of supplementation with fullerene C60 olive/coconut oil solution on a broad spectrum of parameters in rats were examined. The tissue bioaccumulation of C60 was shown to be tissue-specific, with the liver, heart, and adrenal glands being the organs of the greatest, and the kidney, brain, and spleen being the organs of the smallest accumulation. C60 did not change aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase serum activities level, nor the damage of liver cells DNA. There were no effects of fullerene on prooxidant-antioxidant balance in the liver, kidney, spleen, heart, and brain, nor any visible harmful effects on the liver, heart, aorta, spleen, kidney, and small intestine histology. Fullerene changed the gut microbiota structure towards the bacteria that ameliorate lipid homeostasis, causing a serum triglycerides concentration decrease. However, C60 significantly increased the insulin resistance, serum ascorbate oxidation, and brain malondialdehyde and advanced oxidation protein products level. The deteriorative effects of C60 on the brain and serum could be attributed to the specific physicochemical composition of these tissues, potentiating the C60 aggregation or biotransformation as the key element of its pro-oxidative action. PB - Elsevier T2 - Food and Chemical Toxicology T1 - Effects of fullerene C60 supplementation on gut microbiota and glucose and lipid homeostasis in rats VL - 140 SP - 111322 DO - 10.1016/j.fct.2020.111302 ER -
@article{ author = "Đurašević, Siniša and Nikolić, Gorana and Todorović, Ana and Drakulić, Dunja and Pejić, Snežana and Martinović, Vesna and Mitić-Ćulafić, Dragana and Milić, Dragana and Kop, Tatjana and Jasnić, Nebojša and Đorđević, Jelena and Todorović, Zoran", year = "2020", abstract = "The effects of twelve weeks of supplementation with fullerene C60 olive/coconut oil solution on a broad spectrum of parameters in rats were examined. The tissue bioaccumulation of C60 was shown to be tissue-specific, with the liver, heart, and adrenal glands being the organs of the greatest, and the kidney, brain, and spleen being the organs of the smallest accumulation. C60 did not change aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase serum activities level, nor the damage of liver cells DNA. There were no effects of fullerene on prooxidant-antioxidant balance in the liver, kidney, spleen, heart, and brain, nor any visible harmful effects on the liver, heart, aorta, spleen, kidney, and small intestine histology. Fullerene changed the gut microbiota structure towards the bacteria that ameliorate lipid homeostasis, causing a serum triglycerides concentration decrease. However, C60 significantly increased the insulin resistance, serum ascorbate oxidation, and brain malondialdehyde and advanced oxidation protein products level. The deteriorative effects of C60 on the brain and serum could be attributed to the specific physicochemical composition of these tissues, potentiating the C60 aggregation or biotransformation as the key element of its pro-oxidative action.", publisher = "Elsevier", journal = "Food and Chemical Toxicology", title = "Effects of fullerene C60 supplementation on gut microbiota and glucose and lipid homeostasis in rats", volume = "140", pages = "111322", doi = "10.1016/j.fct.2020.111302" }
Đurašević, S., Nikolić, G., Todorović, A., Drakulić, D., Pejić, S., Martinović, V., Mitić-Ćulafić, D., Milić, D., Kop, T., Jasnić, N., Đorđević, J.,& Todorović, Z.. (2020). Effects of fullerene C60 supplementation on gut microbiota and glucose and lipid homeostasis in rats. in Food and Chemical Toxicology Elsevier., 140, 111322. https://doi.org/10.1016/j.fct.2020.111302
Đurašević S, Nikolić G, Todorović A, Drakulić D, Pejić S, Martinović V, Mitić-Ćulafić D, Milić D, Kop T, Jasnić N, Đorđević J, Todorović Z. Effects of fullerene C60 supplementation on gut microbiota and glucose and lipid homeostasis in rats. in Food and Chemical Toxicology. 2020;140:111322. doi:10.1016/j.fct.2020.111302 .
Đurašević, Siniša, Nikolić, Gorana, Todorović, Ana, Drakulić, Dunja, Pejić, Snežana, Martinović, Vesna, Mitić-Ćulafić, Dragana, Milić, Dragana, Kop, Tatjana, Jasnić, Nebojša, Đorđević, Jelena, Todorović, Zoran, "Effects of fullerene C60 supplementation on gut microbiota and glucose and lipid homeostasis in rats" in Food and Chemical Toxicology, 140 (2020):111322, https://doi.org/10.1016/j.fct.2020.111302 . .