Effects of fullerene C60 supplementation on gut microbiota and glucose and lipid homeostasis in rats
Authorized Users Only
2020
Authors
Đurašević, Siniša
Nikolić, Gorana
Todorović, Ana

Drakulić, Dunja

Pejić, Snežana

Martinović, Vesna

Mitić-Ćulafić, Dragana

Milić, Dragana

Kop, Tatjana

Jasnić, Nebojša

Đorđević, Jelena

Todorović, Zoran

Article (Published version)

Elsevier
Metadata
Show full item recordAbstract
The effects of twelve weeks of supplementation with fullerene C60 olive/coconut oil solution on a broad spectrum of parameters in rats were examined. The tissue bioaccumulation of C60 was shown to be tissue-specific, with the liver, heart, and adrenal glands being the organs of the greatest, and the kidney, brain, and spleen being the organs of the smallest accumulation. C60 did not change aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase serum activities level, nor the damage of liver cells DNA. There were no effects of fullerene on prooxidant-antioxidant balance in the liver, kidney, spleen, heart, and brain, nor any visible harmful effects on the liver, heart, aorta, spleen, kidney, and small intestine histology. Fullerene changed the gut microbiota structure towards the bacteria that ameliorate lipid homeostasis, causing a serum triglycerides concentration decrease. However, C60 significantly increased the insulin resistance, serum ascorbate oxidation, ...and brain malondialdehyde and advanced oxidation protein products level. The deteriorative effects of C60 on the brain and serum could be attributed to the specific physicochemical composition of these tissues, potentiating the C60 aggregation or biotransformation as the key element of its pro-oxidative action.
Keywords:
Fullerene C60 / Glucose homeostasis / Lipid homeostasis / Gut microbiota / RatsSource:
Food and Chemical Toxicology, 2020, 140, 111322-Publisher:
- Elsevier
Projects:
- Effects of metabolic and nonmetabolic stressors on the expression and action of neuroendocrine regulators of energy homeostasis (RS-173023)
- Signaling molecules in diabetes: search for potential targets in intrinsic pathways for prediction and intervention in diabetes (RS-173020)
- Design, synthesis and investigations of fullerene based nanomolecular machines (RS-172002)
- Bioactive natural products as potential sources of new pharmaceuticals and food supplements (RS-172058)
- Cellular and molecular basis of malignant and cardiovascular diseases-clinical implications (RS-41027)
DOI: 10.1016/j.fct.2020.111302
ISSN: 0278-6915