Show simple item record

dc.creatorSović, Irena
dc.creatorCindrić, Maja
dc.creatorPerin, Nataša
dc.creatorBoček, Ida
dc.creatorNovaković, Irena
dc.creatorDamjanović, Ana
dc.creatorStanojković, Tatjana
dc.creatorZlatović, Mario
dc.creatorHranjec, Marijana
dc.creatorBertoša, Branimir
dc.date.accessioned2020-02-24T09:03:49Z
dc.date.available2020-02-24T09:03:49Z
dc.date.issued2019
dc.identifier.issn0893-228X
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/3851
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/3416
dc.description.abstractThis paper discusses antioxidative and biological activities of 25 novel amidino substituted benzamides with a variety of heteroaromatic nuclei attached to the benzamide moiety and with a variable number of methoxy or hydroxy substituents. Targeted compounds, bearing either amidino or 2-imidazolinyl substituent, were obtained in the Pinner reaction from cyano precursors. 3D-QSAR models were generated to predict antioxidative activity of the 25 novel aromatic and heteroaromatic benzamide derivatives. The compounds were tested for antioxidative activity using in vitro spectrophotometric assays. Direct validation of 3D-QSAR approach for predicting activities of novel benzamide derivatives was carried out by comparing experimental and computationally predicted antioxidative activity. Experimentally determined activities for all novel compounds were found to be within a standard deviation of error of the models. Following this, structure–activity relationships among the synthesized compounds are discussed. Furthermore, antiproliferative activity in vitro against HeLa cells as well as antibacterial and antifungal activity was tested to confirm the other biological activities of the prepared compounds.sr
dc.language.isoensr
dc.publisherAmerican Chemical Societysr
dc.relationCroatian Science Foundation under the project 4379 entitled Exploring the antioxidative potential of benzazole scaffold in the design of novel antitumor agents.sr
dc.rightsrestrictedAccesssr
dc.sourceChemical Research in Toxicologysr
dc.titleBiological Potential of Novel Methoxy and Hydroxy Substituted Heteroaromatic Amides Designed as Promising Antioxidative Agents: Synthesis, 3D-QSAR Analysis, and Biological Activity.sr
dc.typearticlesr
dc.rights.licenseARRsr
dcterms.abstractСтанојковић, Татјана; Новаковић, Ирена; Дамјановић, Aна; Златовић, Марио; Совић, Ирена; Циндрић, Маја; Перин, Наташа; Бочек, Ида; Храњец, Маријана; Бертоша, Бранимир;
dc.rights.holderAmerican Chemical Societysr
dc.citation.volume32
dc.citation.issue9
dc.citation.spage1880
dc.citation.epage1892
dc.citation.rankM21~
dc.description.otherThe peer-reviewed version: [http://cer.ihtm.bg.ac.rs/handle/123456789/3464]
dc.identifier.doi10.1021/acs.chemrestox.9b00256
dc.identifier.scopus2-s2.0-85071730814
dc.identifier.wos000486565700015
dc.type.versionpublishedVersionsr


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record