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dc.creatorKommera, Harish
dc.creatorKaluđerović, Goran N.
dc.creatorKalbitz, Jutta
dc.creatorPaschke, Reinhard
dc.date.accessioned2020-02-15T19:44:33Z
dc.date.available2020-02-15T19:44:33Z
dc.date.issued2011
dc.identifier.issn01676997
dc.identifier.issn1573-0646
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/3411
dc.description.abstractIn the present investigation the antiproliferative activity of thirteen derivatives of betulinic acid and betulin was tested against five different tumor cell lines. The toxicity against normal human fibroblasts (WWO70327) and the mode of cell death on HT-29 (colon cancer) as well as caspase activity induced by the most active compounds, 9 (3-O-chloroacetylbetulinic acid) and 15 (28-O-chloroacetylbetulin) were determined. Investigated derivatives exerted a dose dependent antiproliferative action at micromolar concentrations toward target tumor cell lines. Treatment of HT-29 cells for 24 h with 9 and 15 induced apoptosis, as observed by dye exclusion test (trypan blue) and confirmed by the appearance of a typical ladder pattern in the DNA fragmentation assay.sr
dc.language.isoensr
dc.publisherNetherlands : Springersr
dc.relationThe authors are grateful to the Wirtschaftsministerium Sachsen-Anhalt for financial support (Antitumor drugs on the basis of natural compounds FuE 62/05).sr
dc.rightsrestrictedAccesssr
dc.sourceInvestigational New Drugssr
dc.subjectCaspase activitysr
dc.subjectCytotoxicitysr
dc.subjectApoptosissr
dc.subjectNatural productssr
dc.subjectBetulinsr
dc.subjectBetulinic acidsr
dc.titleLupane Triterpenoids—Betulin and Betulinic acid derivatives induce apoptosis in tumor cellssr
dc.typearticlesr
dc.rights.licenseARRsr
dcterms.abstractКоммера, Харисх; Калуђеровић, Горан Н.; Калбитз, Јутта; Пасцхке, Реинхард; Лупане Тритерпеноидс—Бетулин анд Бетулиниц ацид деривативес индуце апоптосис ин тумор целлс; Лупане Тритерпеноидс—Бетулин анд Бетулиниц ацид деривативес индуце апоптосис ин тумор целлс;
dc.citation.volume29
dc.citation.issue2
dc.citation.spage266
dc.citation.epage272
dc.identifier.pmid19957199
dc.identifier.doi10.1007/s10637-009-9358-x
dc.identifier.scopus2-s2.0-79955594006
dc.identifier.wos000287248100008
dc.type.versionpublishedVersionsr


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