Desipramine solubility studies: enhanced solubility due to drug-buffer aggregates
Authors
Marković, Olivera
Pešić, Miloš P.

Shah, Ankita V.
Serajuddin, Abu T. M.

Avdeef, Alex

Verbić, Tatjana

Conference object (Published version)
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The solution behavior of desipramine hydrochloride (DsHCl) in phosphate-buffered and unbuffered solutions is evidently complicated and only tentatively understood. The computer program pDISOL-X was used to design the structured pH-ramp shake flask experiments (pHRSF method), to process the data, and to refine the equilibrium constants.
Keywords:
desipramine hydrochloride / pH-ramp shake flask / pDISOL-X computer program / equilibrium constantsSource:
8th World Conference on Physico-Chemical Methods in Drug Discovery, Split, Croatia, September 9-11, 2019 - Book of Abstracts, 2019, 17-17Publisher:
- International Association of Physical Chemists
Funding / projects:
- The synthesis of aminoquinoline-based antimalarials and botulinum neurotoxin A inhibitors (RS-172008)
- Rational design and synthesis of biologically active and coordination compounds and functional materials, relevant for (bio)nanotechnology (RS-172035)
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Institution/Community
IHTMTY - CONF AU - Marković, Olivera AU - Pešić, Miloš P. AU - Shah, Ankita V. AU - Serajuddin, Abu T. M. AU - Avdeef, Alex AU - Verbić, Tatjana PY - 2019 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/3405 AB - The solution behavior of desipramine hydrochloride (DsHCl) in phosphate-buffered and unbuffered solutions is evidently complicated and only tentatively understood. The computer program pDISOL-X was used to design the structured pH-ramp shake flask experiments (pHRSF method), to process the data, and to refine the equilibrium constants. PB - International Association of Physical Chemists C3 - 8th World Conference on Physico-Chemical Methods in Drug Discovery, Split, Croatia, September 9-11, 2019 - Book of Abstracts T1 - Desipramine solubility studies: enhanced solubility due to drug-buffer aggregates SP - 17 EP - 17 UR - https://hdl.handle.net/21.15107/rcub_cer_3405 ER -
@conference{ author = "Marković, Olivera and Pešić, Miloš P. and Shah, Ankita V. and Serajuddin, Abu T. M. and Avdeef, Alex and Verbić, Tatjana", year = "2019", abstract = "The solution behavior of desipramine hydrochloride (DsHCl) in phosphate-buffered and unbuffered solutions is evidently complicated and only tentatively understood. The computer program pDISOL-X was used to design the structured pH-ramp shake flask experiments (pHRSF method), to process the data, and to refine the equilibrium constants.", publisher = "International Association of Physical Chemists", journal = "8th World Conference on Physico-Chemical Methods in Drug Discovery, Split, Croatia, September 9-11, 2019 - Book of Abstracts", title = "Desipramine solubility studies: enhanced solubility due to drug-buffer aggregates", pages = "17-17", url = "https://hdl.handle.net/21.15107/rcub_cer_3405" }
Marković, O., Pešić, M. P., Shah, A. V., Serajuddin, A. T. M., Avdeef, A.,& Verbić, T.. (2019). Desipramine solubility studies: enhanced solubility due to drug-buffer aggregates. in 8th World Conference on Physico-Chemical Methods in Drug Discovery, Split, Croatia, September 9-11, 2019 - Book of Abstracts International Association of Physical Chemists., 17-17. https://hdl.handle.net/21.15107/rcub_cer_3405
Marković O, Pešić MP, Shah AV, Serajuddin ATM, Avdeef A, Verbić T. Desipramine solubility studies: enhanced solubility due to drug-buffer aggregates. in 8th World Conference on Physico-Chemical Methods in Drug Discovery, Split, Croatia, September 9-11, 2019 - Book of Abstracts. 2019;:17-17. https://hdl.handle.net/21.15107/rcub_cer_3405 .
Marković, Olivera, Pešić, Miloš P., Shah, Ankita V., Serajuddin, Abu T. M., Avdeef, Alex, Verbić, Tatjana, "Desipramine solubility studies: enhanced solubility due to drug-buffer aggregates" in 8th World Conference on Physico-Chemical Methods in Drug Discovery, Split, Croatia, September 9-11, 2019 - Book of Abstracts (2019):17-17, https://hdl.handle.net/21.15107/rcub_cer_3405 .