Приказ основних података о документу
Measurements of plasma protein binding – variety of experimental techniques
dc.creator | Marković, Olivera | |
dc.creator | Konstantinović, Jelena M. | |
dc.creator | Cvijetić, Ilija | |
dc.creator | Amézqueta, Susana | |
dc.creator | Valko, Klara | |
dc.creator | Ràfols, Clara | |
dc.creator | Polović, Natalija | |
dc.creator | Šolaja, Bogdan | |
dc.creator | Verbić, Tatjana | |
dc.date.accessioned | 2020-02-12T15:56:00Z | |
dc.date.available | 2020-02-12T15:56:00Z | |
dc.date.issued | 2017 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/3403 | |
dc.description.abstract | Drug molecules in vivo may be bound to proteins and lipids in plasma and/or in tissues, or free (unbound) in diffusion among the aqueous environment of the blood and tissues. Data from in vitro plasma protein binding experiments that determine the fraction of protein-bound drug are frequently used in drug discovery. Methods used for drug – plasma protein binding (PPB) studies are numerous and can be divided into two main groups: separation methods (enabling the calculation of binding parameters, i.e. the number of binding sites and their respective affinity constants) and non-separation methods (describing predominantly qualitative parameters of the ligand-protein complex). | en |
dc.language.iso | en | sr |
dc.publisher | International Association of Physical Chemists | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172008/RS// | sr |
dc.rights | openAccess | sr |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | 6th World Conference on Physico-Chemical Methods in Drug Discovery, Zagreb, Croatia, September 4-7, 2017 - Book of Abstracts | sr |
dc.subject | protein binding | sr |
dc.subject | in vitro plasma protein binding experiments | sr |
dc.subject | drug – plasma protein binding | sr |
dc.subject | experimental techniques | sr |
dc.title | Measurements of plasma protein binding – variety of experimental techniques | en |
dc.type | conferenceObject | sr |
dc.rights.license | BY | sr |
dcterms.abstract | Цвијетић, Илија Н.; Марковић, Оливера; Константиновић, Јелена М.; Aмéзqуета, Сусана; Валко, Клара; Рàфолс, Цлара; Половић, Наталија Ђ.; Шолаја, Богдан A.; Вербић, Татјана Ж.; | |
dc.citation.spage | 30 | |
dc.citation.epage | 30 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_cer_3403 | |
dc.identifier.fulltext | https://cer.ihtm.bg.ac.rs/bitstream/id/16051/bitstream_16051.pdf | |
dc.type.version | publishedVersion | sr |