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pH-Dependent solubility profile of desipramine hydrochloride

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2017
Saopštenje sa međunarodnog skupa štampano u izvodu (1.154Mb)
Authors
Marković, Olivera
Pešić, Miloš P.
Verbić, Tatjana
Avdeef, Alex
Conference object (Published version)
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Abstract
pH-dependent solubility profile of Desipramine hydrochloride (Ds.HCl) was studied using pH-ramp shake flask method. First, the pH value of DsHCl stock solution in 0.15 M phosphate buffer was adjusted to 11.7 in order to minimize supersaturation effect. Then, the pH value in separate samples was adjusted downwards with HCl, to prepare solutions in the pH 1.7-11.7 region. After stirring (6 h) and sedimentation (18 h), PTFE (hydrophobic, pore size 0.22 µm) filters or centrifugation were used for phase separation. Concentration was measured using HPLC with UV/Vis detection. The computer program pDISOL-X was used for data processing and refinement of equilibrium constants. Different techniques were used for solid phase characterization.
Keywords:
pH-dependent solubility / Desipramine hydrochloride / pH-ramp shake flask method
Source:
6th World Conference on Physico-Chemical Methods in Drug Discovery Zagreb, Croatia, September 4-7, 2017 - Book of Abstracts, 2017, 42-42
Publisher:
  • International Association of Physical Chemists
Projects:
  • Rational design and synthesis of biologically active and coordination compounds and functional materials, relevant for (bio)nanotechnology (RS-172035)
  • The synthesis of aminoquinoline-based antimalarials and botulinum neurotoxin A inhibitors (RS-172008)
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URI
http://cer.ihtm.bg.ac.rs/handle/123456789/3402
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IHTM

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