pH-Dependent solubility profile of desipramine hydrochloride
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pH-dependent solubility profile of Desipramine hydrochloride (Ds.HCl) was studied using pH-ramp shake flask method. First, the pH value of DsHCl stock solution in 0.15 M phosphate buffer was adjusted to 11.7 in order to minimize supersaturation effect. Then, the pH value in separate samples was adjusted downwards with HCl, to prepare solutions in the pH 1.7-11.7 region. After stirring (6 h) and sedimentation (18 h), PTFE (hydrophobic, pore size 0.22 µm) filters or centrifugation were used for phase separation. Concentration was measured using HPLC with UV/Vis detection. The computer program pDISOL-X was used for data processing and refinement of equilibrium constants. Different techniques were used for solid phase characterization.
Keywords:pH-dependent solubility / Desipramine hydrochloride / pH-ramp shake flask method
Source:6th World Conference on Physico-Chemical Methods in Drug Discovery Zagreb, Croatia, September 4-7, 2017 - Book of Abstracts, 2017, 42-42
- International Association of Physical Chemists