Human serum albumin binding of certain antimalarials
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Tested compounds, previously synthesized, are derivatives of chloroquine, drug commonly used in the treatment and prevention of malaria. Interaction between tested compounds and Human serum albumin (HSA) has been studied by fluorescence spectroscopy in phosphate buffered saline (1× PBS, pH 7.4) . Molecular docking studies were used to determine HSA–compound binding mode.
Keywords:Human serum albumin / fluorescence spectroscopy / docking / binding mode
Source:4th World Conference on Physico-Chemical Methods in Drug Discovery and Development Red Island, Croatia, September 21-24, 2015 - Book of Abstracts, 2015, 67-67
- International Association of Physical Chemists