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Polysaccharide-fullerene supramolecular hybrids: Synthesis, characterization and antioxidant activity

Authorized Users Only
2020
Authors
Kop, Tatjana
Jakovljević, Dragica
Živković, Ljiljana S.
Žekić, Andrijana
Beškoski, Vladimir
Milić, Dragana
Gojgić-Cvijović, Gordana
Bjelaković, Mira
Article (Published version)
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Abstract
An efficient encapsulation of the fullerene into two hydrophobized and one native polysaccharide provided water soluble supramolecular hybrids. After covalent modification of polysaccharides by cholesterol, noncovalent hybrids were prepared by a three-step procedure, including mixing of individual aqueous solutions of hydrophobized, as well as native sugar with solution of the fullerene in pyridine, dialysis and lyophilization. Although the degree of the fullerene incorporation into hydrophobized substrates, cholesterol-levan and cholesterol-pullulan, was lower in comparison to the native polysaccharide levan, hydrophobization provided nanoparticles with improved properties. The particle size distribution, studied by dynamic light scattering and scanning electron microscopy revealed formation of moderately polydisperse aggregates, with the diameter contraction in comparison to the corresponding free polysaccharide, especially in the case of hydrophobized substrates. The morphological e...xamination, done by scanning electron microscopy indicated the self-organization of the fullerene-native polysaccharide to round individual structures, while fullerene-hydrophobized polysaccharide hybrids tend to form networks. The antioxidant activity of the synthesized polysaccharide-C60 noncovalent hybrids versus starting polysaccharides was investigated by the DPPH radical scavenging and the β-carotene-linoleic acid bleaching methods. In all three complexes, the radical scavenging ability of the fullerene remained preserved, and a positive effect of levan hydrophobization was observed.

Keywords:
Antioxidant activity / Cholesterol-levan conjugate / DLS / Hydrophobized polysaccharides / Polysaccharide-C60 nanoparticles / SEM
Source:
European Polymer Journal, 2020, 123, 109461-
Publisher:
  • Elsevier
Projects:
  • Design, synthesis and investigations of fullerene based nanomolecular machines (RS-172002)
  • Simultaneous Bioremediation and Soilification of Degraded Areas to Preserve Natural Resources of Biologically Active Substances, and Development and Production of Biomaterials and Dietetic Products (RS-43004)
Note:
  • The peer-reviewed version: http://cer.ihtm.bg.ac.rs/handle/123456789/3336

DOI: 10.1016/j.eurpolymj.2019.109461

ISSN: 0014-3057

WoS: 000510956600028

Scopus: 2-s2.0-85077109347
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URI
http://cer.ihtm.bg.ac.rs/handle/123456789/3332
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