Analysis of the Fundamental Detection Limit in Microfluidic Chemical and Biological Sensors
Authors
Jokić, Ivana
Radulović, Katarina

Frantlović, Miloš

Đurić, Zoran G.

Cvetanović Zobenica, Katarina

Krstajić, Predrag

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Detection limits in microfluidic chemical and biological sensors, which determine the range of analyte concentrations reliably detectable by the sensor, are important sensor parameters. The lower limit of detection, defined as the lowest concentration that can be distinguished from noise, has its minimum determined by the fundamental adsorption-desorption (AD) noise, inevitable in adsorption-based devices. In this work, we analyze this fundamental detection limit, particularly considering the influence of mass transfer processes in microfluidic devices. For that purpose, we derive the expression for the sensor’s signal-to-noise ratio (SNR), which takes into account the AD noise, and then the equation for the minimal analyte concentration at which the SNR has a sufficiently high value for reliable analyte detection. Subsequently, we analyze the mass transfer influence on the sensor’s maximal achievable signal-to-noise ratio and on the fundamental detection limit. The results of the anal...ysis show a significant mass transfer influence on these important sensor performance metrics. They also provide guidelines for achieving the sensor’s best possible detection performance through the optimization of the sensor design and operating conditions.
Keywords:
microfluidic sensors / biosensors / chemical sensors / detection limit / mass transfer / signal-to-noise ratioSource:
Proceedings of Papers – 6th International Conference on Electrical, Electronic and Computing Engineering, IcETRAN 2019, Silver Lake, Serbia, June 03 – 06, 2019 / Zbornik radova - 63. Konferencija za elektroniku, telekomunikacije, računarstvo, automatiku i nuklearnu tehniku, Srebrno jezero, 03 – 06. juna, 2019. godine, 2019, 571-574Publisher:
- Belgrade : ETRAN
- Belgrade :Academic Mind
Funding / projects:
- Micro- Nanosystems and Sensors for Electric Power and Process Industry and Environmental Protection (RS-32008)
- Serbian Academy of Sciences and Arts, Project F-150
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IHTMTY - CONF AU - Jokić, Ivana AU - Radulović, Katarina AU - Frantlović, Miloš AU - Đurić, Zoran G. AU - Cvetanović Zobenica, Katarina AU - Krstajić, Predrag PY - 2019 UR - http://dais.sanu.ac.rs/123456789/6961 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/3326 AB - Detection limits in microfluidic chemical and biological sensors, which determine the range of analyte concentrations reliably detectable by the sensor, are important sensor parameters. The lower limit of detection, defined as the lowest concentration that can be distinguished from noise, has its minimum determined by the fundamental adsorption-desorption (AD) noise, inevitable in adsorption-based devices. In this work, we analyze this fundamental detection limit, particularly considering the influence of mass transfer processes in microfluidic devices. For that purpose, we derive the expression for the sensor’s signal-to-noise ratio (SNR), which takes into account the AD noise, and then the equation for the minimal analyte concentration at which the SNR has a sufficiently high value for reliable analyte detection. Subsequently, we analyze the mass transfer influence on the sensor’s maximal achievable signal-to-noise ratio and on the fundamental detection limit. The results of the analysis show a significant mass transfer influence on these important sensor performance metrics. They also provide guidelines for achieving the sensor’s best possible detection performance through the optimization of the sensor design and operating conditions. PB - Belgrade : ETRAN PB - Belgrade :Academic Mind C3 - Proceedings of Papers – 6th International Conference on Electrical, Electronic and Computing Engineering, IcETRAN 2019, Silver Lake, Serbia, June 03 – 06, 2019 / Zbornik radova - 63. Konferencija za elektroniku, telekomunikacije, računarstvo, automatiku i nuklearnu tehniku, Srebrno jezero, 03 – 06. juna, 2019. godine T1 - Analysis of the Fundamental Detection Limit in Microfluidic Chemical and Biological Sensors SP - 571 EP - 574 UR - https://hdl.handle.net/21.15107/rcub_dais_6961 ER -
@conference{ author = "Jokić, Ivana and Radulović, Katarina and Frantlović, Miloš and Đurić, Zoran G. and Cvetanović Zobenica, Katarina and Krstajić, Predrag", year = "2019", abstract = "Detection limits in microfluidic chemical and biological sensors, which determine the range of analyte concentrations reliably detectable by the sensor, are important sensor parameters. The lower limit of detection, defined as the lowest concentration that can be distinguished from noise, has its minimum determined by the fundamental adsorption-desorption (AD) noise, inevitable in adsorption-based devices. In this work, we analyze this fundamental detection limit, particularly considering the influence of mass transfer processes in microfluidic devices. For that purpose, we derive the expression for the sensor’s signal-to-noise ratio (SNR), which takes into account the AD noise, and then the equation for the minimal analyte concentration at which the SNR has a sufficiently high value for reliable analyte detection. Subsequently, we analyze the mass transfer influence on the sensor’s maximal achievable signal-to-noise ratio and on the fundamental detection limit. The results of the analysis show a significant mass transfer influence on these important sensor performance metrics. They also provide guidelines for achieving the sensor’s best possible detection performance through the optimization of the sensor design and operating conditions.", publisher = "Belgrade : ETRAN, Belgrade :Academic Mind", journal = "Proceedings of Papers – 6th International Conference on Electrical, Electronic and Computing Engineering, IcETRAN 2019, Silver Lake, Serbia, June 03 – 06, 2019 / Zbornik radova - 63. Konferencija za elektroniku, telekomunikacije, računarstvo, automatiku i nuklearnu tehniku, Srebrno jezero, 03 – 06. juna, 2019. godine", title = "Analysis of the Fundamental Detection Limit in Microfluidic Chemical and Biological Sensors", pages = "571-574", url = "https://hdl.handle.net/21.15107/rcub_dais_6961" }
Jokić, I., Radulović, K., Frantlović, M., Đurić, Z. G., Cvetanović Zobenica, K.,& Krstajić, P.. (2019). Analysis of the Fundamental Detection Limit in Microfluidic Chemical and Biological Sensors. in Proceedings of Papers – 6th International Conference on Electrical, Electronic and Computing Engineering, IcETRAN 2019, Silver Lake, Serbia, June 03 – 06, 2019 / Zbornik radova - 63. Konferencija za elektroniku, telekomunikacije, računarstvo, automatiku i nuklearnu tehniku, Srebrno jezero, 03 – 06. juna, 2019. godine Belgrade : ETRAN., 571-574. https://hdl.handle.net/21.15107/rcub_dais_6961
Jokić I, Radulović K, Frantlović M, Đurić ZG, Cvetanović Zobenica K, Krstajić P. Analysis of the Fundamental Detection Limit in Microfluidic Chemical and Biological Sensors. in Proceedings of Papers – 6th International Conference on Electrical, Electronic and Computing Engineering, IcETRAN 2019, Silver Lake, Serbia, June 03 – 06, 2019 / Zbornik radova - 63. Konferencija za elektroniku, telekomunikacije, računarstvo, automatiku i nuklearnu tehniku, Srebrno jezero, 03 – 06. juna, 2019. godine. 2019;:571-574. https://hdl.handle.net/21.15107/rcub_dais_6961 .
Jokić, Ivana, Radulović, Katarina, Frantlović, Miloš, Đurić, Zoran G., Cvetanović Zobenica, Katarina, Krstajić, Predrag, "Analysis of the Fundamental Detection Limit in Microfluidic Chemical and Biological Sensors" in Proceedings of Papers – 6th International Conference on Electrical, Electronic and Computing Engineering, IcETRAN 2019, Silver Lake, Serbia, June 03 – 06, 2019 / Zbornik radova - 63. Konferencija za elektroniku, telekomunikacije, računarstvo, automatiku i nuklearnu tehniku, Srebrno jezero, 03 – 06. juna, 2019. godine (2019):571-574, https://hdl.handle.net/21.15107/rcub_dais_6961 .