Silver-based monomer and coordination polymer with organic thiocyanate ligand: Structural, computational and antiproliferative activity study
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2019
Authors
Filipović, Nenad R.
Ristić, Predrag

Janjić, Goran

Klisurić, Olivera
Puerta, Adrián
Padrón, José M.

Donnard, Morgan

Gulea, Mihaela

Todorović, Tamara R.
Article (Published version)

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The first complexes of 2-pyridylthiocyanate (L) and silver nitrate (1) and perchlorate (2) were prepared
and characterized by a single crystal X-ray analysis. The common structural motif of both 1 and 2 is coordination
of two L molecules via pyridine nitrogen atom to Ag(I). In order to properly describe the nature
of coordinative bonds in 1 and 2, as well as crystal packings in respective structures, a Quantum Theory of
Atoms in Molecule topological analysis was performed. Coordinated nitrate ion provides more electron
density to Ag(I) in comparison to perchlorate ion. Additional electron density in the case of 2 was provided
by the coordination of third L molecule via thiocyanate nitrogen atom resulting in a 1D polymeric
structure. Detailed computational analysis of intermolecular interactions, as well analysis of interactions
between pyridine ring and –SCN group was performed. Antiproliferative activity of monomeric compound
1 was found to be better than of cisplatin on thre...e out of four studied human cancer cell lines.
Docking studies indicate intercalation as a major binding mode of 1 to DNA, while human serum albumin
was revealed as possible carrier for distribution of 1 in the blood stream.
Keywords:
Silver Organic thiocyanates / Coordination polymers / Antiproliferative activity / Docking / program / database / drug / binding / complexes / recognition / sequence / dna / crystal-structuresSource:
Polyhedron, 2019, 173, 114132-Publisher:
- England : Elsevier
Funding / projects:
- Directed synthesis, structure and properties of multifunctional materials (RS-172057)
- Spanish Government for financial support through project PGC2018-094503-B-C22 (MCIU/AEI/FEDER, UE).
DOI: 10.1016/j.poly.2019.114132
ISSN: 02775387
WoS: 000499768700039
Scopus: 2-s2.0-85072584514
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IHTMTY - JOUR AU - Filipović, Nenad R. AU - Ristić, Predrag AU - Janjić, Goran AU - Klisurić, Olivera AU - Puerta, Adrián AU - Padrón, José M. AU - Donnard, Morgan AU - Gulea, Mihaela AU - Todorović, Tamara R. PY - 2019 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/3315 AB - The first complexes of 2-pyridylthiocyanate (L) and silver nitrate (1) and perchlorate (2) were prepared and characterized by a single crystal X-ray analysis. The common structural motif of both 1 and 2 is coordination of two L molecules via pyridine nitrogen atom to Ag(I). In order to properly describe the nature of coordinative bonds in 1 and 2, as well as crystal packings in respective structures, a Quantum Theory of Atoms in Molecule topological analysis was performed. Coordinated nitrate ion provides more electron density to Ag(I) in comparison to perchlorate ion. Additional electron density in the case of 2 was provided by the coordination of third L molecule via thiocyanate nitrogen atom resulting in a 1D polymeric structure. Detailed computational analysis of intermolecular interactions, as well analysis of interactions between pyridine ring and –SCN group was performed. Antiproliferative activity of monomeric compound 1 was found to be better than of cisplatin on three out of four studied human cancer cell lines. Docking studies indicate intercalation as a major binding mode of 1 to DNA, while human serum albumin was revealed as possible carrier for distribution of 1 in the blood stream. PB - England : Elsevier T2 - Polyhedron T1 - Silver-based monomer and coordination polymer with organic thiocyanate ligand: Structural, computational and antiproliferative activity study VL - 173 SP - 114132 DO - 10.1016/j.poly.2019.114132 ER -
@article{ author = "Filipović, Nenad R. and Ristić, Predrag and Janjić, Goran and Klisurić, Olivera and Puerta, Adrián and Padrón, José M. and Donnard, Morgan and Gulea, Mihaela and Todorović, Tamara R.", year = "2019", abstract = "The first complexes of 2-pyridylthiocyanate (L) and silver nitrate (1) and perchlorate (2) were prepared and characterized by a single crystal X-ray analysis. The common structural motif of both 1 and 2 is coordination of two L molecules via pyridine nitrogen atom to Ag(I). In order to properly describe the nature of coordinative bonds in 1 and 2, as well as crystal packings in respective structures, a Quantum Theory of Atoms in Molecule topological analysis was performed. Coordinated nitrate ion provides more electron density to Ag(I) in comparison to perchlorate ion. Additional electron density in the case of 2 was provided by the coordination of third L molecule via thiocyanate nitrogen atom resulting in a 1D polymeric structure. Detailed computational analysis of intermolecular interactions, as well analysis of interactions between pyridine ring and –SCN group was performed. Antiproliferative activity of monomeric compound 1 was found to be better than of cisplatin on three out of four studied human cancer cell lines. Docking studies indicate intercalation as a major binding mode of 1 to DNA, while human serum albumin was revealed as possible carrier for distribution of 1 in the blood stream.", publisher = "England : Elsevier", journal = "Polyhedron", title = "Silver-based monomer and coordination polymer with organic thiocyanate ligand: Structural, computational and antiproliferative activity study", volume = "173", pages = "114132", doi = "10.1016/j.poly.2019.114132" }
Filipović, N. R., Ristić, P., Janjić, G., Klisurić, O., Puerta, A., Padrón, J. M., Donnard, M., Gulea, M.,& Todorović, T. R.. (2019). Silver-based monomer and coordination polymer with organic thiocyanate ligand: Structural, computational and antiproliferative activity study. in Polyhedron England : Elsevier., 173, 114132. https://doi.org/10.1016/j.poly.2019.114132
Filipović NR, Ristić P, Janjić G, Klisurić O, Puerta A, Padrón JM, Donnard M, Gulea M, Todorović TR. Silver-based monomer and coordination polymer with organic thiocyanate ligand: Structural, computational and antiproliferative activity study. in Polyhedron. 2019;173:114132. doi:10.1016/j.poly.2019.114132 .
Filipović, Nenad R., Ristić, Predrag, Janjić, Goran, Klisurić, Olivera, Puerta, Adrián, Padrón, José M., Donnard, Morgan, Gulea, Mihaela, Todorović, Tamara R., "Silver-based monomer and coordination polymer with organic thiocyanate ligand: Structural, computational and antiproliferative activity study" in Polyhedron, 173 (2019):114132, https://doi.org/10.1016/j.poly.2019.114132 . .