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Chemical modification of the lectin of the marine coral Gerardia savaglia by marine quinone avarone

Hemijske modifikacije lektina morskog korala Gerardia savaglia morskim hinonom avaronom

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2007
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Authors
Pajic, Ivana
Vujčić, Zoran
Vujčić, Miroslava
Novaković, Irena
Sladić, Dušan
Gašić, Miroslav J.
Article (Published version)
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Abstract
The quinone avarone, isolated from the marine sponge Dysidea avara, possesses the ability to chemically modify proteins. In this work, modification of lectin isolated from the coral Gerardia savaglia by avarone was examined. The techniques used for studying the modification were: SDS PAGE, isoelectric focusing and hemagglutination testing. The results of the SDS PAGE indicate dimerization of the protein. A shift of the pI toward lower value occurs upon modification. The change of the hemagglutination activity of the protein confirms that chemical modification of G. savaglia lectin by avarone changes its ability to interact with the membrane of erythrocytes.
Avaron, hinon izolovan iz morskog sunđera Dysidea avara, poseduje sposobnost da hemijski modifikuje proteine. U ovom radu ispitivana je modifikacija lektina izolovanog iz korala Gerardia savaglia avaronom. Tehnike za praćenje hemijske modifikacije bile su: SDS PAGE, izoelektrično fokusiranje i hemaglutinacioni test. Rezultati SDS PAGE upućuju na dimerizaciju proteina. Dolazi do pomeranja pI vrednosti proteina. Promena hemaglutinacione aktivnosti G. savaglia lektina avaronom uticala je na njegovu sposobnost interakcije sa membranom eritrocita.
Keywords:
avarone / quinone / Gerardia savaglia lectin / covalent modification
Source:
Journal of the Serbian Chemical Society, 2007, 72, 12, 1271-1274
Publisher:
  • Serbian Chemical Soc, Belgrade
Projects:
  • Interakcije prirodnih proizvoda i njihovih analoga sa proteinima i nukleinskim kiselinama (RS-142026)

DOI: 10.2298/JSC0712271P

ISSN: 0352-5139

WoS: 000252412100011

Scopus: 2-s2.0-36949025210
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URI
http://cer.ihtm.bg.ac.rs/handle/123456789/330
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