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dc.creatorTrifunović-Macedoljan, Jelena
dc.creatorPantelić, Nebojša Đ.
dc.creatorJadranin, Milka
dc.creatorJuranić, Ivan
dc.date.accessioned2019-12-18T12:31:53Z
dc.date.available2019-12-18T12:31:53Z
dc.date.issued2019
dc.identifier.issn0035-3930
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/3261
dc.description.abstractThe biosynthetic pathway of biogenic amines is very active during the growth of many tumour cells. Non-Hodgkin lymphoma represents a very heterogeneous group of malignancies. The concentration level of some biogenic amines (putrescine, histamine, spermidine, epinephrine, and spermine) was investigated to elucidate whether they could be observed as markers for the patients with non-Hodgkin’s lymphoma. In this study, the method of acidic extraction of five biogenic amines from human serum, dansyl chloride pre-column derivatization, and LC/DAD analysis were used to determine the content of biogenic amines in biological fluids. The results indicate that statistically significant differences exist in putrescine, spermidine and histamine contents in non-Hodgkin’s patients versus healthy controls. The concentrations of putrescine, spermidine and epinephrine were elevated, and histamine was lower compared to controls. Based on their content, serum biogenic amines could be considered as potential tumour markers.en
dc.publisherEditura Academiei Romane
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS//
dc.rightsrestrictedAccess
dc.sourceRevue Roumaine de Chimie
dc.subjectBiogenic amines
dc.subjectLC/DAD
dc.subjectserum
dc.subjectnon-Hodgkin's lymphoma
dc.titleBiogenic amines content in the serum of patients with non-Hodgkin’s lymphomaen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЈадранин, Милка; Трифуновић-Мацедољан, Јелена; Јуранић, Иван; Пантелић, Небојша Ђ.;
dc.citation.volume64
dc.citation.issue8
dc.citation.spage681
dc.citation.epage686
dc.citation.rankM23~
dc.identifier.doi10.3224/rrch.2019.64.8.05
dc.identifier.scopus2-s2.0-85074940032
dc.identifier.wos000495592100005
dc.type.versionpublishedVersion


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