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dc.creatorNikolić, Stefan
dc.creatorGrgurić-Šipka, Sanja
dc.creatorĐorđević, Ivana
dc.creatorDahmani, Rahma
dc.creatorDekanski, Dragana
dc.creatorVidičević, Sašenka
dc.creatorTošić, Jelena
dc.creatorMitić, Dragana
dc.creatorGrubišić, Sonja
dc.date.accessioned2019-12-18T12:11:45Z
dc.date.available2019-12-18T12:11:45Z
dc.date.issued2019
dc.identifier.issn0095-8972
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/3259
dc.description.abstractIn search for antitumor metal-based drugs that would mitigate the severe side-effects of cisplatin, Ru(II) complexes are gaining increasing recent interest. In this work, we report on the synthesis, characterization (1H- and 13C-NMR, FT-IR), and cytotoxicity studies of two new half-sandwich organometallic Ru(II) complexes of the general formula [Ru(η6-arene)(XY)Cl](PF6) where arene = benzene or toluene and XY = bidentates: dipyrido[3,2-a:2′,3′-c]phenazine (dppz) or 2-(9-anthryl)-1H-imidazo[4,5-f][1,10]phenanthroline (aip), which are bound to Ru(II) via two phenanthroline-N atoms in a characteristic “piano-stool” configuration of Ru(II)-arene complexes—as confirmed by vibrational and NMR spectra. In addition, cytotoxic studies were performed for similar half-sandwich organometallic [Ru(η6-p-cymene)(Me2dppz)Cl]PF6 complex (Me2dppz = 11,12-dimethyl-dipyrido[3,2-a:2′,3′-c]phenazine). This study is complemented with elaborate modeling with density functional theory (DFT) calculations, which provided insight into reactive sites of Ru(II) structures, further detailed by molecular docking on the B-DNA dodecamer, which identified binding sites and affinities: most pronounced for the [Ru(η6-benzene)(aip)Cl](PF6) in both A-T and G-C regions of the DNA minor groove. Cytotoxic activity was probed versus tumor cell lines B16, C6, and U251 (B16 mouse melanoma, C6 rat glioma, U251 human glioblastoma) and non-tumor cell line HACAT (HACAT normal human keratinocytes).
dc.publisherTaylor & Francis
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS//
dc.relationCOST CMST-Action CM1405 Molecules in Motion (MOLIM)
dc.rightsrestrictedAccess
dc.sourceJournal of Coordination Chemistry
dc.subjectcytotoxicity studies
dc.subjectDFT calculations
dc.subjectDNA docking
dc.subjectintercalation
dc.subjectRuthenium complexes
dc.titleHalf-sandwich ruthenium(II)-arene complexes: synthesis, spectroscopic studies, biological properties, and molecular modeling
dc.typearticle
dc.rights.licenseARR
dcterms.abstractДекански, Драгана; Николић, Стефан; Гргурић-Шипка, Сања; Грубишић, Соња; Ђорђевић, Ивана; Дахмани, Рахма; Видичевић, Сашенка; Тошић, Јелена; Митић, Драгана;
dc.citation.volume72
dc.citation.issue1
dc.citation.spage148
dc.citation.epage163
dc.citation.rankM22~
dc.description.otherPeer-reviewed manuscript: [http://cer.ihtm.bg.ac.rs/handle/123456789/3260]
dc.identifier.doi10.1080/00958972.2018.1553298
dc.identifier.scopus2-s2.0-85064599205
dc.identifier.wos000465181600009
dc.type.versionpublishedVersion


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