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dc.creatorÐurđić, Slađana
dc.creatorStanković, V.
dc.creatorPerić, Marko
dc.creatorOgnjanović, Miloš
dc.creatorŠovrc, Ľubomír
dc.creatorMutić, Jelena
dc.creatorStanković, Dalibor
dc.date.accessioned2019-12-18T07:38:05Z
dc.date.available2019-12-18T07:38:05Z
dc.date.issued2019
dc.identifier.issn0013-4651
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/3253
dc.description.abstractIn present work boron doped diamond (BDD) electrode was applied for studying electrochemical behavior, as well as for quantitative determination of natural alkaloid, tubocurarine (arrow poison/ TUB). Electrochemical behavior was investigated using several organic solvents and aqueous buffers, at different pHs, as supporting electrolytes. After selection of the most appropriate supporting electrolyte and investigation of its electrochemical behavior, analytical procedures for quantitative analysis of TUB were developed in an acetonitrile/methanol (80:20) mixture and in 1 mol L−1 nitric acid, which had linear quantification ranges from 4 × 10−6 to 1 × 10−4 mol L−1 (LOD = 3.07 × 10−6 mol L−1) and 4 × 10−6 to 9 × 10−5 mol L−1 (LOD = 2.45 × 10−6 mol L−1 and 5.28 × 10−7 mol L−1, depending on the selected peak), respectively. The oxidation mechanism of TUB was proposed from the theoretical aspect. Remarkable selectivity and good sensitivity were obtained after the TUB quantification method was optimized, allowing application of the developed method for TUB quantification in biological fluids, with excellent reproducibility, accuracy and precision.
dc.publisherElectrochemical Society Inc.
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172030/RS//
dc.relationGrant Agency of the Slovak Republic (grant No. 1/0489/16)
dc.rightsrestrictedAccess
dc.sourceJournal of the Electrochemical Society
dc.subjecthuman urine samples
dc.subjectvoltammetric determination
dc.subjectsensitive determination
dc.subjectdrug
dc.subjectsensors
dc.subjectquantification
dc.subjectapproximation
dc.subjectenergy
dc.titleElectrochemistry of the arrow poison, tubocurarine, using boron doped diamond electrode: Experimental and theoretical approaches
dc.typearticle
dc.rights.licenseARR
dcterms.abstractОгњановић, Милош; Мутић, Јелена; Ðурђић, Слађана; Станковић, Далибор; Станковић, В.; Перић, М.; Шоврц, Ľубомíр;
dc.citation.volume166
dc.citation.issue14
dc.citation.spageG157
dc.citation.epageG161
dc.citation.rankM21
dc.identifier.doi10.1149/2.1241914jes
dc.identifier.scopus2-s2.0-85074076971
dc.identifier.wos000490166300001
dc.type.versionpublishedVersion


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