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Electrochemistry of the arrow poison, tubocurarine, using boron doped diamond electrode: Experimental and theoretical approaches

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2019
Authors
Ðurđić, Slađana
Stanković, V.
Perić, Marko
Ognjanović, Miloš
Šovrc, Ľubomír
Mutić, Jelena
Stanković, Dalibor
Article (Published version)
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Abstract
In present work boron doped diamond (BDD) electrode was applied for studying electrochemical behavior, as well as for quantitative determination of natural alkaloid, tubocurarine (arrow poison/ TUB). Electrochemical behavior was investigated using several organic solvents and aqueous buffers, at different pHs, as supporting electrolytes. After selection of the most appropriate supporting electrolyte and investigation of its electrochemical behavior, analytical procedures for quantitative analysis of TUB were developed in an acetonitrile/methanol (80:20) mixture and in 1 mol L−1 nitric acid, which had linear quantification ranges from 4 × 10−6 to 1 × 10−4 mol L−1 (LOD = 3.07 × 10−6 mol L−1) and 4 × 10−6 to 9 × 10−5 mol L−1 (LOD = 2.45 × 10−6 mol L−1 and 5.28 × 10−7 mol L−1, depending on the selected peak), respectively. The oxidation mechanism of TUB was proposed from the theoretical aspect. Remarkable selectivity and good sensitivity were obtained after the TUB quantification method wa...s optimized, allowing application of the developed method for TUB quantification in biological fluids, with excellent reproducibility, accuracy and precision.

Keywords:
human urine samples / voltammetric determination / sensitive determination / drug / sensors / quantification / approximation / energy
Source:
Journal of the Electrochemical Society, 2019, 166, 14, G157-G161
Publisher:
  • Electrochemical Society Inc.
Funding / projects:
  • Application of advanced oxidation processes and nanostructured oxide materials for the removal of pollutants from the environment, development and optimisation of instrumental techniques for efficiency monitoring (RS-172030)
  • Grant Agency of the Slovak Republic (grant No. 1/0489/16)

DOI: 10.1149/2.1241914jes

ISSN: 0013-4651

WoS: 000490166300001

Scopus: 2-s2.0-85074076971
[ Google Scholar ]
4
3
URI
https://cer.ihtm.bg.ac.rs/handle/123456789/3253
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
IHTM
TY  - JOUR
AU  - Ðurđić, Slađana
AU  - Stanković, V.
AU  - Perić, Marko
AU  - Ognjanović, Miloš
AU  - Šovrc, Ľubomír
AU  - Mutić, Jelena
AU  - Stanković, Dalibor
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3253
AB  - In present work boron doped diamond (BDD) electrode was applied for studying electrochemical behavior, as well as for quantitative determination of natural alkaloid, tubocurarine (arrow poison/ TUB). Electrochemical behavior was investigated using several organic solvents and aqueous buffers, at different pHs, as supporting electrolytes. After selection of the most appropriate supporting electrolyte and investigation of its electrochemical behavior, analytical procedures for quantitative analysis of TUB were developed in an acetonitrile/methanol (80:20) mixture and in 1 mol L−1 nitric acid, which had linear quantification ranges from 4 × 10−6 to 1 × 10−4 mol L−1 (LOD = 3.07 × 10−6 mol L−1) and 4 × 10−6 to 9 × 10−5 mol L−1 (LOD = 2.45 × 10−6 mol L−1 and 5.28 × 10−7 mol L−1, depending on the selected peak), respectively. The oxidation mechanism of TUB was proposed from the theoretical aspect. Remarkable selectivity and good sensitivity were obtained after the TUB quantification method was optimized, allowing application of the developed method for TUB quantification in biological fluids, with excellent reproducibility, accuracy and precision.
PB  - Electrochemical Society Inc.
T2  - Journal of the Electrochemical Society
T1  - Electrochemistry of the arrow poison, tubocurarine, using boron doped diamond electrode: Experimental and theoretical approaches
VL  - 166
IS  - 14
SP  - G157
EP  - G161
DO  - 10.1149/2.1241914jes
ER  - 
@article{
author = "Ðurđić, Slađana and Stanković, V. and Perić, Marko and Ognjanović, Miloš and Šovrc, Ľubomír and Mutić, Jelena and Stanković, Dalibor",
year = "2019",
abstract = "In present work boron doped diamond (BDD) electrode was applied for studying electrochemical behavior, as well as for quantitative determination of natural alkaloid, tubocurarine (arrow poison/ TUB). Electrochemical behavior was investigated using several organic solvents and aqueous buffers, at different pHs, as supporting electrolytes. After selection of the most appropriate supporting electrolyte and investigation of its electrochemical behavior, analytical procedures for quantitative analysis of TUB were developed in an acetonitrile/methanol (80:20) mixture and in 1 mol L−1 nitric acid, which had linear quantification ranges from 4 × 10−6 to 1 × 10−4 mol L−1 (LOD = 3.07 × 10−6 mol L−1) and 4 × 10−6 to 9 × 10−5 mol L−1 (LOD = 2.45 × 10−6 mol L−1 and 5.28 × 10−7 mol L−1, depending on the selected peak), respectively. The oxidation mechanism of TUB was proposed from the theoretical aspect. Remarkable selectivity and good sensitivity were obtained after the TUB quantification method was optimized, allowing application of the developed method for TUB quantification in biological fluids, with excellent reproducibility, accuracy and precision.",
publisher = "Electrochemical Society Inc.",
journal = "Journal of the Electrochemical Society",
title = "Electrochemistry of the arrow poison, tubocurarine, using boron doped diamond electrode: Experimental and theoretical approaches",
volume = "166",
number = "14",
pages = "G157-G161",
doi = "10.1149/2.1241914jes"
}
Ðurđić, S., Stanković, V., Perić, M., Ognjanović, M., Šovrc, Ľ., Mutić, J.,& Stanković, D.. (2019). Electrochemistry of the arrow poison, tubocurarine, using boron doped diamond electrode: Experimental and theoretical approaches. in Journal of the Electrochemical Society
Electrochemical Society Inc.., 166(14), G157-G161.
https://doi.org/10.1149/2.1241914jes
Ðurđić S, Stanković V, Perić M, Ognjanović M, Šovrc Ľ, Mutić J, Stanković D. Electrochemistry of the arrow poison, tubocurarine, using boron doped diamond electrode: Experimental and theoretical approaches. in Journal of the Electrochemical Society. 2019;166(14):G157-G161.
doi:10.1149/2.1241914jes .
Ðurđić, Slađana, Stanković, V., Perić, Marko, Ognjanović, Miloš, Šovrc, Ľubomír, Mutić, Jelena, Stanković, Dalibor, "Electrochemistry of the arrow poison, tubocurarine, using boron doped diamond electrode: Experimental and theoretical approaches" in Journal of the Electrochemical Society, 166, no. 14 (2019):G157-G161,
https://doi.org/10.1149/2.1241914jes . .

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