Electrochemistry of the arrow poison, tubocurarine, using boron doped diamond electrode: Experimental and theoretical approaches
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2019
Authors
Ðurđić, SlađanaStanković, V.
Perić, Marko

Ognjanović, Miloš

Šovrc, Ľubomír
Mutić, Jelena

Stanković, Dalibor

Article (Published version)

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In present work boron doped diamond (BDD) electrode was applied for studying electrochemical behavior, as well as for quantitative determination of natural alkaloid, tubocurarine (arrow poison/ TUB). Electrochemical behavior was investigated using several organic solvents and aqueous buffers, at different pHs, as supporting electrolytes. After selection of the most appropriate supporting electrolyte and investigation of its electrochemical behavior, analytical procedures for quantitative analysis of TUB were developed in an acetonitrile/methanol (80:20) mixture and in 1 mol L−1 nitric acid, which had linear quantification ranges from 4 × 10−6 to 1 × 10−4 mol L−1 (LOD = 3.07 × 10−6 mol L−1) and 4 × 10−6 to 9 × 10−5 mol L−1 (LOD = 2.45 × 10−6 mol L−1 and 5.28 × 10−7 mol L−1, depending on the selected peak), respectively. The oxidation mechanism of TUB was proposed from the theoretical aspect. Remarkable selectivity and good sensitivity were obtained after the TUB quantification method wa...s optimized, allowing application of the developed method for TUB quantification in biological fluids, with excellent reproducibility, accuracy and precision.
Keywords:
human urine samples / voltammetric determination / sensitive determination / drug / sensors / quantification / approximation / energySource:
Journal of the Electrochemical Society, 2019, 166, 14, G157-G161Publisher:
- Electrochemical Society Inc.
Funding / projects:
- Application of advanced oxidation processes and nanostructured oxide materials for the removal of pollutants from the environment, development and optimisation of instrumental techniques for efficiency monitoring (RS-172030)
- Grant Agency of the Slovak Republic (grant No. 1/0489/16)
DOI: 10.1149/2.1241914jes
ISSN: 0013-4651
WoS: 000490166300001
Scopus: 2-s2.0-85074076971
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IHTMTY - JOUR AU - Ðurđić, Slađana AU - Stanković, V. AU - Perić, Marko AU - Ognjanović, Miloš AU - Šovrc, Ľubomír AU - Mutić, Jelena AU - Stanković, Dalibor PY - 2019 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/3253 AB - In present work boron doped diamond (BDD) electrode was applied for studying electrochemical behavior, as well as for quantitative determination of natural alkaloid, tubocurarine (arrow poison/ TUB). Electrochemical behavior was investigated using several organic solvents and aqueous buffers, at different pHs, as supporting electrolytes. After selection of the most appropriate supporting electrolyte and investigation of its electrochemical behavior, analytical procedures for quantitative analysis of TUB were developed in an acetonitrile/methanol (80:20) mixture and in 1 mol L−1 nitric acid, which had linear quantification ranges from 4 × 10−6 to 1 × 10−4 mol L−1 (LOD = 3.07 × 10−6 mol L−1) and 4 × 10−6 to 9 × 10−5 mol L−1 (LOD = 2.45 × 10−6 mol L−1 and 5.28 × 10−7 mol L−1, depending on the selected peak), respectively. The oxidation mechanism of TUB was proposed from the theoretical aspect. Remarkable selectivity and good sensitivity were obtained after the TUB quantification method was optimized, allowing application of the developed method for TUB quantification in biological fluids, with excellent reproducibility, accuracy and precision. PB - Electrochemical Society Inc. T2 - Journal of the Electrochemical Society T1 - Electrochemistry of the arrow poison, tubocurarine, using boron doped diamond electrode: Experimental and theoretical approaches VL - 166 IS - 14 SP - G157 EP - G161 DO - 10.1149/2.1241914jes ER -
@article{ author = "Ðurđić, Slađana and Stanković, V. and Perić, Marko and Ognjanović, Miloš and Šovrc, Ľubomír and Mutić, Jelena and Stanković, Dalibor", year = "2019", abstract = "In present work boron doped diamond (BDD) electrode was applied for studying electrochemical behavior, as well as for quantitative determination of natural alkaloid, tubocurarine (arrow poison/ TUB). Electrochemical behavior was investigated using several organic solvents and aqueous buffers, at different pHs, as supporting electrolytes. After selection of the most appropriate supporting electrolyte and investigation of its electrochemical behavior, analytical procedures for quantitative analysis of TUB were developed in an acetonitrile/methanol (80:20) mixture and in 1 mol L−1 nitric acid, which had linear quantification ranges from 4 × 10−6 to 1 × 10−4 mol L−1 (LOD = 3.07 × 10−6 mol L−1) and 4 × 10−6 to 9 × 10−5 mol L−1 (LOD = 2.45 × 10−6 mol L−1 and 5.28 × 10−7 mol L−1, depending on the selected peak), respectively. The oxidation mechanism of TUB was proposed from the theoretical aspect. Remarkable selectivity and good sensitivity were obtained after the TUB quantification method was optimized, allowing application of the developed method for TUB quantification in biological fluids, with excellent reproducibility, accuracy and precision.", publisher = "Electrochemical Society Inc.", journal = "Journal of the Electrochemical Society", title = "Electrochemistry of the arrow poison, tubocurarine, using boron doped diamond electrode: Experimental and theoretical approaches", volume = "166", number = "14", pages = "G157-G161", doi = "10.1149/2.1241914jes" }
Ðurđić, S., Stanković, V., Perić, M., Ognjanović, M., Šovrc, Ľ., Mutić, J.,& Stanković, D.. (2019). Electrochemistry of the arrow poison, tubocurarine, using boron doped diamond electrode: Experimental and theoretical approaches. in Journal of the Electrochemical Society Electrochemical Society Inc.., 166(14), G157-G161. https://doi.org/10.1149/2.1241914jes
Ðurđić S, Stanković V, Perić M, Ognjanović M, Šovrc Ľ, Mutić J, Stanković D. Electrochemistry of the arrow poison, tubocurarine, using boron doped diamond electrode: Experimental and theoretical approaches. in Journal of the Electrochemical Society. 2019;166(14):G157-G161. doi:10.1149/2.1241914jes .
Ðurđić, Slađana, Stanković, V., Perić, Marko, Ognjanović, Miloš, Šovrc, Ľubomír, Mutić, Jelena, Stanković, Dalibor, "Electrochemistry of the arrow poison, tubocurarine, using boron doped diamond electrode: Experimental and theoretical approaches" in Journal of the Electrochemical Society, 166, no. 14 (2019):G157-G161, https://doi.org/10.1149/2.1241914jes . .