Thin-layer chromatography in medicinal chemistry
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2019
Article (Published version)

Taylor & Francis
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Show full item recordAbstract
Among widely used chromatographic methods modern thin-layer chromatography is not only the
simplest to perform but is also considered as respectable analytical method in various phases of
drug discovery and development processes such as monitoring of synthesis, identification of bioactive
substances from various natural sources and their isolation and purification, determination
of lipophilicity and other physico-chemical parameters, quantitative structure-activity relationship
studies, bioautography, as well as qualitative and quantitative analysis of drugs and their metabolites. An overview of recently published papers dealing with application of thin-layer chromatography in medicinal chemistry is presented.
Keywords:
Thin-layer chromatography / medicinal chemistry / ADMET parameters / bioautography / lipophilicity / TLC in drug developmentSource:
Journal of Liquid Chromatography & Related Technologies, 2019, 42, 9-10, 238-248Publisher:
- Taylor & Francis Inc.
Projects:
- The synthesis of aminoquinoline-based antimalarials and botulinum neurotoxin A inhibitors (RS-172008)
- Structure-properties relationships of natural and synthetic molecules and their metal complexes (RS-172017)
DOI: 10.1080/10826076.2019.1585615
ISSN: 1082-6076; 1520-572X