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Thin-layer chromatography in medicinal chemistry

Authorized Users Only
2019
Authors
Šegan, Sandra
Opsenica, Dejan
Milojković-Opsenica, Dušanka
Article (Published version)
,
Taylor & Francis
Metadata
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Abstract
Among widely used chromatographic methods modern thin-layer chromatography is not only the simplest to perform but is also considered as respectable analytical method in various phases of drug discovery and development processes such as monitoring of synthesis, identification of bioactive substances from various natural sources and their isolation and purification, determination of lipophilicity and other physico-chemical parameters, quantitative structure-activity relationship studies, bioautography, as well as qualitative and quantitative analysis of drugs and their metabolites. An overview of recently published papers dealing with application of thin-layer chromatography in medicinal chemistry is presented.
Keywords:
Thin-layer chromatography / medicinal chemistry / ADMET parameters / bioautography / lipophilicity / TLC in drug development
Source:
Journal of Liquid Chromatography & Related Technologies, 2019, 42, 9-10, 238-248
Publisher:
  • Taylor & Francis Inc.
Projects:
  • The synthesis of aminoquinoline-based antimalarials and botulinum neurotoxin A inhibitors (RS-172008)
  • Structure-properties relationships of natural and synthetic molecules and their metal complexes (RS-172017)

DOI: 10.1080/10826076.2019.1585615

ISSN: 1082-6076; 1520-572X

WoS: 000465830800001

Scopus: 2-s2.0-85064253810
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URI
http://cer.ihtm.bg.ac.rs/handle/123456789/3205
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IHTM

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