Thin-layer chromatography in medicinal chemistry
Authorized Users Only
2019
Article (Published version)

Taylor & Francis
Metadata
Show full item recordAbstract
Among widely used chromatographic methods modern thin-layer chromatography is not only the
simplest to perform but is also considered as respectable analytical method in various phases of
drug discovery and development processes such as monitoring of synthesis, identification of bioactive
substances from various natural sources and their isolation and purification, determination
of lipophilicity and other physico-chemical parameters, quantitative structure-activity relationship
studies, bioautography, as well as qualitative and quantitative analysis of drugs and their metabolites. An overview of recently published papers dealing with application of thin-layer chromatography in medicinal chemistry is presented.
Keywords:
Thin-layer chromatography / medicinal chemistry / ADMET parameters / bioautography / lipophilicity / TLC in drug developmentSource:
Journal of Liquid Chromatography & Related Technologies, 2019, 42, 9-10, 238-248Publisher:
- Taylor & Francis Inc.
Funding / projects:
- The synthesis of aminoquinoline-based antimalarials and botulinum neurotoxin A inhibitors (RS-172008)
- Structure-properties relationships of natural and synthetic molecules and their metal complexes (RS-172017)
DOI: 10.1080/10826076.2019.1585615
ISSN: 1082-6076; 1520-572X
WoS: 000465830800001
Scopus: 2-s2.0-85064253810
Collections
Institution/Community
IHTMTY - JOUR AU - Šegan, Sandra AU - Opsenica, Dejan AU - Milojković-Opsenica, Dušanka PY - 2019 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/3205 AB - Among widely used chromatographic methods modern thin-layer chromatography is not only the simplest to perform but is also considered as respectable analytical method in various phases of drug discovery and development processes such as monitoring of synthesis, identification of bioactive substances from various natural sources and their isolation and purification, determination of lipophilicity and other physico-chemical parameters, quantitative structure-activity relationship studies, bioautography, as well as qualitative and quantitative analysis of drugs and their metabolites. An overview of recently published papers dealing with application of thin-layer chromatography in medicinal chemistry is presented. PB - Taylor & Francis Inc. T2 - Journal of Liquid Chromatography & Related Technologies T1 - Thin-layer chromatography in medicinal chemistry VL - 42 IS - 9-10 SP - 238 EP - 248 DO - 10.1080/10826076.2019.1585615 ER -
@article{ author = "Šegan, Sandra and Opsenica, Dejan and Milojković-Opsenica, Dušanka", year = "2019", abstract = "Among widely used chromatographic methods modern thin-layer chromatography is not only the simplest to perform but is also considered as respectable analytical method in various phases of drug discovery and development processes such as monitoring of synthesis, identification of bioactive substances from various natural sources and their isolation and purification, determination of lipophilicity and other physico-chemical parameters, quantitative structure-activity relationship studies, bioautography, as well as qualitative and quantitative analysis of drugs and their metabolites. An overview of recently published papers dealing with application of thin-layer chromatography in medicinal chemistry is presented.", publisher = "Taylor & Francis Inc.", journal = "Journal of Liquid Chromatography & Related Technologies", title = "Thin-layer chromatography in medicinal chemistry", volume = "42", number = "9-10", pages = "238-248", doi = "10.1080/10826076.2019.1585615" }
Šegan, S., Opsenica, D.,& Milojković-Opsenica, D.. (2019). Thin-layer chromatography in medicinal chemistry. in Journal of Liquid Chromatography & Related Technologies Taylor & Francis Inc.., 42(9-10), 238-248. https://doi.org/10.1080/10826076.2019.1585615
Šegan S, Opsenica D, Milojković-Opsenica D. Thin-layer chromatography in medicinal chemistry. in Journal of Liquid Chromatography & Related Technologies. 2019;42(9-10):238-248. doi:10.1080/10826076.2019.1585615 .
Šegan, Sandra, Opsenica, Dejan, Milojković-Opsenica, Dušanka, "Thin-layer chromatography in medicinal chemistry" in Journal of Liquid Chromatography & Related Technologies, 42, no. 9-10 (2019):238-248, https://doi.org/10.1080/10826076.2019.1585615 . .