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Thin-layer chromatography in medicinal chemistry

Authorized Users Only
2019
Authors
Šegan, Sandra
Opsenica, Dejan
Milojković-Opsenica, Dušanka
Article (Published version)
,
Taylor & Francis
Metadata
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Abstract
Among widely used chromatographic methods modern thin-layer chromatography is not only the simplest to perform but is also considered as respectable analytical method in various phases of drug discovery and development processes such as monitoring of synthesis, identification of bioactive substances from various natural sources and their isolation and purification, determination of lipophilicity and other physico-chemical parameters, quantitative structure-activity relationship studies, bioautography, as well as qualitative and quantitative analysis of drugs and their metabolites. An overview of recently published papers dealing with application of thin-layer chromatography in medicinal chemistry is presented.
Keywords:
Thin-layer chromatography / medicinal chemistry / ADMET parameters / bioautography / lipophilicity / TLC in drug development
Source:
Journal of Liquid Chromatography & Related Technologies, 2019, 42, 9-10, 238-248
Publisher:
  • Taylor & Francis Inc.
Projects:
  • The synthesis of aminoquinoline-based antimalarials and botulinum neurotoxin A inhibitors (RS-172008)
  • Structure-properties relationships of natural and synthetic molecules and their metal complexes (RS-172017)

DOI: 10.1080/10826076.2019.1585615

ISSN: 1082-6076; 1520-572X

WoS: 000465830800001

Scopus: 2-s2.0-85064253810
[ Google Scholar ]
5
5
URI
http://cer.ihtm.bg.ac.rs/handle/123456789/3205
Collections
  • Radovi istraživača / Researchers' publications
Institution
IHTM
TY  - JOUR
AU  - Šegan, Sandra
AU  - Opsenica, Dejan
AU  - Milojković-Opsenica, Dušanka
PY  - 2019
UR  - http://cer.ihtm.bg.ac.rs/handle/123456789/3205
AB  - Among widely used chromatographic methods modern thin-layer chromatography is not only the
simplest to perform but is also considered as respectable analytical method in various phases of
drug discovery and development processes such as monitoring of synthesis, identification of bioactive
substances from various natural sources and their isolation and purification, determination
of lipophilicity and other physico-chemical parameters, quantitative structure-activity relationship
studies, bioautography, as well as qualitative and quantitative analysis of drugs and their metabolites. An overview of recently published papers dealing with application of thin-layer chromatography in medicinal chemistry is presented.
PB  - Taylor & Francis Inc.
T2  - Journal of Liquid Chromatography & Related Technologies
T1  - Thin-layer chromatography in medicinal chemistry
VL  - 42
IS  - 9-10
SP  - 238
EP  - 248
DO  - 10.1080/10826076.2019.1585615
ER  - 
@article{
author = "Šegan, Sandra and Opsenica, Dejan and Milojković-Opsenica, Dušanka",
year = "2019",
url = "http://cer.ihtm.bg.ac.rs/handle/123456789/3205",
abstract = "Among widely used chromatographic methods modern thin-layer chromatography is not only the
simplest to perform but is also considered as respectable analytical method in various phases of
drug discovery and development processes such as monitoring of synthesis, identification of bioactive
substances from various natural sources and their isolation and purification, determination
of lipophilicity and other physico-chemical parameters, quantitative structure-activity relationship
studies, bioautography, as well as qualitative and quantitative analysis of drugs and their metabolites. An overview of recently published papers dealing with application of thin-layer chromatography in medicinal chemistry is presented.",
publisher = "Taylor & Francis Inc.",
journal = "Journal of Liquid Chromatography & Related Technologies",
title = "Thin-layer chromatography in medicinal chemistry",
volume = "42",
number = "9-10",
pages = "238-248",
doi = "10.1080/10826076.2019.1585615"
}
Šegan S, Opsenica D, Milojković-Opsenica D. Thin-layer chromatography in medicinal chemistry. Journal of Liquid Chromatography & Related Technologies. 2019;42(9-10):238-248
Šegan, S., Opsenica, D.,& Milojković-Opsenica, D. (2019). Thin-layer chromatography in medicinal chemistry.
Journal of Liquid Chromatography & Related TechnologiesTaylor & Francis Inc.., 42(9-10), 238-248.
https://doi.org/10.1080/10826076.2019.1585615
Šegan Sandra, Opsenica Dejan, Milojković-Opsenica Dušanka, "Thin-layer chromatography in medicinal chemistry" 42, no. 9-10 (2019):238-248,
https://doi.org/10.1080/10826076.2019.1585615 .

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