The isothermal kinetics of the release of the drug (E)-4-(4-metoxyphenyl)-4-oxo-2-butenoic acid (MEPBA) from poly(acrylic acid) hydrogel were studied. The isothermal kinetic curves of MEPBA release from the poly(acrylic acid) hydrogel in bidistilled water at different temperatures ranging from 22 °C to 42 °C were determined. The reaction rate constants of the investigated process were determined using the initial rate, saturation rate and power law. Also, to quickly determine the kinetic model of drug release, the so-called method of reduced time was applied. The influence of the degree of the MEPBA released (α) at the values of the kinetic parameters as well as the presence of a compensation effect was established. The procedure for determining the distribution function of activation energies was developed. This procedure was based on the experimentally determined relationship between the activation energy and the degree of drug released. The process of MEPBA release from PAA hydrogel..., almost in entire range, can be described with the model of the drug desorption from the active centers with different specific energies.
TY - JOUR
AU - Adnađević, Borivoj
AU - Jovanović, Jelena
AU - Drakulić, Branko
PY - 2007
UR - https://cer.ihtm.bg.ac.rs/handle/123456789/3191
AB - The isothermal kinetics of the release of the drug (E)-4-(4-metoxyphenyl)-4-oxo-2-butenoic acid (MEPBA) from poly(acrylic acid) hydrogel were studied. The isothermal kinetic curves of MEPBA release from the poly(acrylic acid) hydrogel in bidistilled water at different temperatures ranging from 22 °C to 42 °C were determined. The reaction rate constants of the investigated process were determined using the initial rate, saturation rate and power law. Also, to quickly determine the kinetic model of drug release, the so-called method of reduced time was applied. The influence of the degree of the MEPBA released (α) at the values of the kinetic parameters as well as the presence of a compensation effect was established. The procedure for determining the distribution function of activation energies was developed. This procedure was based on the experimentally determined relationship between the activation energy and the degree of drug released. The process of MEPBA release from PAA hydrogel, almost in entire range, can be described with the model of the drug desorption from the active centers with different specific energies.
PB - Elsevier
T2 - Thermochimica Acta
T1 - Isothermal kinetics of (E)-4-(4-metoxyphenyl)-4-oxo-2-butenoic acid release from poly(acrylic acid) hydrogel
VL - 466
IS - 1-2
SP - 38
EP - 48
DO - 10.1016/j.tca.2007.10.009
ER -
@article{
author = "Adnađević, Borivoj and Jovanović, Jelena and Drakulić, Branko",
year = "2007",
abstract = "The isothermal kinetics of the release of the drug (E)-4-(4-metoxyphenyl)-4-oxo-2-butenoic acid (MEPBA) from poly(acrylic acid) hydrogel were studied. The isothermal kinetic curves of MEPBA release from the poly(acrylic acid) hydrogel in bidistilled water at different temperatures ranging from 22 °C to 42 °C were determined. The reaction rate constants of the investigated process were determined using the initial rate, saturation rate and power law. Also, to quickly determine the kinetic model of drug release, the so-called method of reduced time was applied. The influence of the degree of the MEPBA released (α) at the values of the kinetic parameters as well as the presence of a compensation effect was established. The procedure for determining the distribution function of activation energies was developed. This procedure was based on the experimentally determined relationship between the activation energy and the degree of drug released. The process of MEPBA release from PAA hydrogel, almost in entire range, can be described with the model of the drug desorption from the active centers with different specific energies.",
publisher = "Elsevier",
journal = "Thermochimica Acta",
title = "Isothermal kinetics of (E)-4-(4-metoxyphenyl)-4-oxo-2-butenoic acid release from poly(acrylic acid) hydrogel",
volume = "466",
number = "1-2",
pages = "38-48",
doi = "10.1016/j.tca.2007.10.009"
}
Adnađević, B., Jovanović, J.,& Drakulić, B.. (2007). Isothermal kinetics of (E)-4-(4-metoxyphenyl)-4-oxo-2-butenoic acid release from poly(acrylic acid) hydrogel. in Thermochimica Acta
Elsevier., 466(1-2), 38-48.
https://doi.org/10.1016/j.tca.2007.10.009
Adnađević B, Jovanović J, Drakulić B. Isothermal kinetics of (E)-4-(4-metoxyphenyl)-4-oxo-2-butenoic acid release from poly(acrylic acid) hydrogel. in Thermochimica Acta. 2007;466(1-2):38-48.
doi:10.1016/j.tca.2007.10.009 .
Adnađević, Borivoj, Jovanović, Jelena, Drakulić, Branko, "Isothermal kinetics of (E)-4-(4-metoxyphenyl)-4-oxo-2-butenoic acid release from poly(acrylic acid) hydrogel" in Thermochimica Acta, 466, no. 1-2 (2007):38-48,
https://doi.org/10.1016/j.tca.2007.10.009 . .
