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dc.creatorKommera, Harish
dc.creatorKaluđerović, Goran N.
dc.creatorKalbitz, Jutta
dc.creatorDräger, Birgit
dc.creatorPaschke, Reinhard
dc.date.accessioned2019-10-25T12:29:01Z
dc.date.available2019-10-25T12:29:01Z
dc.date.issued2010
dc.identifier.issn02235234
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/3179
dc.description.abstractIn the present investigations five new derivatives of betulinic and betulonic acid were synthesized and the effect of this structural variations on anticancer activity was studied and discussed. The antiproliferative activity of betulinic and betulonic acid derivatives was studied against eight tumor cell lines of different histogenic origin. The derivatives exerted a dose dependent antiproliferative action at micromolar concentrations toward target tumor cell lines. The apoptotic mode of cell death on colon cancer cell line HT-29 was induced by the most active compounds 5, 2-amino-3-hydroxy-2-(hydroxymethyl)propyl (3-O-acetyl)betulinate, and 9, 2-amino-3-hydroxy-2-(hydroxymethyl)propyl betulonate. Treatment of HT-29 cells with 5 and 9 induced apoptosis, as observed by dye exclusion test (trypan blue) and by the appearance of a typical ladder pattern in the DNA fragmentation assay and FITC annexin V assay. Cell cycle perturbations caused by compound 5 are also presented.
dc.publisherElsevier BVen
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Medicinal Chemistryen
dc.subjectBetulinic acid
dc.subjectBetulonic acid
dc.subjectAntitumoral activity
dc.subjectApoptosis
dc.subjectCell cycle
dc.titleSmall structural changes of pentacyclic lupane type triterpenoid derivatives lead to significant differences in their anticancer propertiesen
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractКоммера, Харисх; Пасцхке, Реинхард; Калуђеровић, Горан Н.; Дрäгер, Биргит; Калбитз, Јутта;
dc.citation.volume45
dc.citation.issue8
dc.citation.spage3346
dc.citation.epage3353
dc.identifier.pmid20472329
dc.identifier.doi10.1016/j.ejmech.2010.04.018
dc.identifier.scopus2-s2.0-77954315717
dc.identifier.wos000279521800011
dc.type.versionpublishedVersion


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