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dc.creatorZizic, Jovana B.
dc.creatorVukovic, Nenad L.
dc.creatorJadranin, Milka
dc.creatorAnđelković, Boban D.
dc.creatorTešević, Vele
dc.creatorKacaniova, Miroslava M.
dc.creatorSukdolak, Slobodan B.
dc.creatorMarković, Snežana D.
dc.date.accessioned2019-10-11T14:57:47Z
dc.date.available2014-03-15
dc.date.issued2013
dc.identifier.issn0022-5142
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/3133
dc.description.abstractBACKGROUND Propolis is a complex resinous sticky substance that honeybees collect from buds and exudates of various plants. Owing to its versatile biological and pharmacological activities, propolis is widely used in medicines, cosmetics and foods. The aim of this study was to evaluate the cytotoxic and antioxidative effects of various ethanolic extracts of propolis (EEPs) on human colon cancer cell line HCT-116 and compare them with their composition determined by HPLC-DAD. RESULTS The most abundant flavonoids in all samples were chrysin, pinocembrin and galangin (12.697-40.811 mu gmg(-1)), while the main phenolic acids were caffeic acid, ferulic acid and isoferulic acid. Dose- and time-dependent inhibition of growth of HCT-116 cells was observed for all propolis samples, with IC50 values ranging from 26.33 to 143.09 mu gmL(-1). Differences in cytotoxic activity of propolis samples were associated with differences in their composition. All EEP samples reduced both superoxide anion radical and nitrite levels and also had strong DPPH-scavenging activity. CONCLUSION All tested propolis samples had pronounced cytotoxic and antioxidative activities.en
dc.publisherWiley, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41010/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS//
dc.rightsembargoedAccess
dc.sourceJournal of the Science of Food and Agriculture
dc.subjectpropolisen
dc.subjectpolyphenolsen
dc.subjectcytotoxicityen
dc.subjectantioxidantsen
dc.subjectHCT-116 cell lineen
dc.titleChemical composition, cytotoxic and antioxidative activities of ethanolic extracts of propolis on HCT-116 cell lineen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЈадранин, Милка; Кацаниова, Мирослава М.; Сукдолак, Слободан Б.; Марковић, Снежана Д.; Зизиц, Јована Б.; Aнђелковић, Бобан Д.; Вуковиц, Ненад Л.; Тешевић, Веле;
dc.citation.volume93
dc.citation.issue12
dc.citation.spage3001
dc.citation.epage3009
dc.citation.other93(12): 3001-3009
dc.citation.rankM21
dc.description.otherThis is the peer-reviewed version of the following article: Žižić, J. B.; Vuković, N. L.; Jadranin, M.; Anđelković, B. D.; Tešević, V.; Kacaniova, M. M.; Sukdolak, S. B.; Markovic, S. D. Chemical Composition, Cytotoxic and Antioxidative Activities of Ethanolic Extracts of Propolis on HCT-116 Cell Line. Journal of the Science of Food and Agriculture 2013, 93 (12), 3001–3009. [https://doi.org/10.1002/jsfa.6132]
dc.description.other[http://cer.ihtm.bg.ac.rs/handle/123456789/1213]
dc.identifier.pmid23504630
dc.identifier.doi10.1002/jsfa.6132
dc.identifier.rcubConv_3013
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs/bitstream/id/14121/Chemical_composition_cytotoxic_acc_2013.pdf
dc.identifier.scopus2-s2.0-84881025942
dc.identifier.wos000323100600019
dc.type.versionacceptedVersion


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