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dc.creatorTrifunović, Snežana
dc.creatorIsaković, Anđelka M.
dc.creatorIsaković, Aleksandra
dc.creatorVučković, Ivan
dc.creatorMandić, Boris
dc.creatorNovaković, Miroslav
dc.creatorVajs, Vlatka
dc.creatorMilosavljević, Slobodan
dc.creatorTrajković, Vladimir
dc.date.accessioned2019-09-27T15:36:22Z
dc.date.available2015-01-02
dc.date.available2015-01-02
dc.date.issued2014
dc.identifier.issn0032-0943
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/3120
dc.description.abstractFurther phytochemical investigation into the aerial parts of Achillea clavennae has resulted in the 3 isolation of three new sesquiterpene lactones: two highly oxygenated germacranolides (1, 2) and 4 the iso-seco-guaianolide, 9(R)-acetoxy-3-O-methyl-iso-seco-tanapartholide (3). Eight known 5 compounds were also found in this plant species, of which 9 α -acetoxycanin (5), sintenin (6) and 6 oleanolic acid (7) were detected for the first time. The structures of the isolated compounds were 7 elucidated by combined spectroscopic methods (1D and 2D NMR, HRESIMS, CIMS, FTIR). 8 While the predominant metabolite germacranolide sintenin (6) was not cytotoxic, the new iso-9 seco-guaianolide (3) displayed cytotoxicity comparable to that of cisplatin and the lactone 10 apressin (4), inducing partly apoptotic death in human U251 and rat C6 glioma cell lines.en
dc.language.isoensr
dc.publisherGeorg Thieme Verlagsr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS//sr
dc.rightsembargoedAccesssr
dc.sourcePlanta medicasr
dc.subjectChemosystematicssr
dc.subjectNatural Productssr
dc.titleIsolation, characterization and in vitro cytotoxicity of new sesquiterpenoids from Achillea clavennaeen
dc.typearticlesr
dc.rights.licenseBY-NC-NDsr
dcterms.abstractНоваковић, Мирослав М.; Вучковић, Иван; Исаковић, Aлександра Ј.; Исаковић, Aнђелка М.; Трифуновић, Снежана; Трајковић, Владимир С.; Милосављевић, Слободан М.; Вајс, Влатка; Мандић, Борис;
dc.citation.volume80
dc.citation.issue4
dc.citation.spage275
dc.citation.epage305
dc.citation.rankM21
dc.description.otherThis is the peer-reviewed version of the article: [https://dx.doi.org/10.1055/s-0033-1360312]
dc.description.other[http://cer.ihtm.bg.ac.rs/handle/123456789/1534]
dc.identifier.doi10.1055/s-0033-1360312
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs/bitstream/id/14201/manuscript.pdf
dc.identifier.scopus2-s2.0-84895928430
dc.identifier.wos000332395000008
dc.type.versionacceptedVersionsr


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