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O peroksidnim antimalaricima

dc.creatorOpsenica, Igor
dc.creatorOpsenica, Dejan
dc.creatorJadranin, Milka
dc.creatorSmith, Kirsten
dc.creatorMilhous, Wilbur K.
dc.creatorStratakis, Manolis
dc.creatorŠolaja, Bogdan
dc.date.accessioned2019-01-30T17:15:19Z
dc.date.available2019-01-30T17:15:19Z
dc.date.issued2007
dc.identifier.issn0352-5139
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/303
dc.description.abstractSeveral dicyclohexylidene tetraoxanes were prepared in order to gain a further insight into structure-activity relationship of this kind of antimalarials. The tetraoxanes 2-5, obtained as a cis/trans mixture, showed pronounced antimalarial activity against Plasmodium falciparum chloroquine susceptible D6, chloroquine resistant W2 and multidrug-resistant TM91C235 (Thailand) strains. They have better than or similar activity to the corresponding desmethyl dicyclohexylidene derivatives. Two chimeric endoperoxides with superior antimalarial activity to the natural product ascaridole were also synthesized.en
dc.description.abstractU ovom radu prikazana je sinteza nekoliko dicikiloheksilidenskih tetraoksana u cilju sagledavanja odnosa struktura-aktivnost ove vrste antimalarika. Jedinjenja 2-5 dobijena kao (cis,trans)-smese pokazala su izraženu antimalarijsku aktivnost prema D6, W2 i TM91C235 (Thailand) sojevima P. falciparum. Ona imaju bolju ili sličnu aktivnost od odgovarajućih desmetil cikloheksilidenskih derivata. Sintetisana su i dva endoperoksida himerne strukture znatno izraženije aktivnosti od prirodnog proizvoda askaridola. .sr
dc.publisherSerbian Chemical Society
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142022/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceJournal of the Serbian Chemical Society
dc.subjectmixed tetraoxanesen
dc.subjectendoperoxidesen
dc.subjectmalariaen
dc.subjectP. falciparumen
dc.titleOn peroxide antimalarialsen
dc.titleO peroksidnim antimalaricimasr
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractСтратакис, Манолис; Милхоус, Wилбур К.; Смитх, Кирстен; Опсеница, Игор; Јадранин, Милка; Опсеница, Дејан; Шолаја, Богдан; О пероксидним антималарицима; О пероксидним антималарицима;
dc.citation.volume72
dc.citation.issue12
dc.citation.spage1181
dc.citation.epage1190
dc.citation.other72(12): 1181-1190
dc.citation.rankM23
dc.identifier.doi10.2298/JSC0712181O
dc.identifier.fulltexthttps://cer.ihtm.bg.ac.rs//bitstream/id/8982/301.pdf
dc.identifier.scopus2-s2.0-36949031727
dc.identifier.wos000252412100003
dc.type.versionpublishedVersion


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