On peroxide antimalarials
O peroksidnim antimalaricima
2007
Autori
Opsenica, IgorOpsenica, Dejan
Jadranin, Milka
Smith, Kirsten
Milhous, Wilbur K.
Stratakis, Manolis
Šolaja, Bogdan
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Several dicyclohexylidene tetraoxanes were prepared in order to gain a further insight into structure-activity relationship of this kind of antimalarials. The tetraoxanes 2-5, obtained as a cis/trans mixture, showed pronounced antimalarial activity against Plasmodium falciparum chloroquine susceptible D6, chloroquine resistant W2 and multidrug-resistant TM91C235 (Thailand) strains. They have better than or similar activity to the corresponding desmethyl dicyclohexylidene derivatives. Two chimeric endoperoxides with superior antimalarial activity to the natural product ascaridole were also synthesized.
U ovom radu prikazana je sinteza nekoliko dicikiloheksilidenskih tetraoksana u cilju sagledavanja odnosa struktura-aktivnost ove vrste antimalarika. Jedinjenja 2-5 dobijena kao (cis,trans)-smese pokazala su izraženu antimalarijsku aktivnost prema D6, W2 i TM91C235 (Thailand) sojevima P. falciparum. Ona imaju bolju ili sličnu aktivnost od odgovarajućih desmetil cikloheksilidenskih derivata. Sintetisana su i dva endoperoksida himerne strukture znatno izraženije aktivnosti od prirodnog proizvoda askaridola. .
Ključne reči:
mixed tetraoxanes / endoperoxides / malaria / P. falciparumIzvor:
Journal of the Serbian Chemical Society, 2007, 72, 12, 1181-1190Izdavač:
- Serbian Chemical Society
Finansiranje / projekti:
DOI: 10.2298/JSC0712181O
ISSN: 0352-5139
WoS: 000252412100003
Scopus: 2-s2.0-36949031727
Institucija/grupa
IHTMTY - JOUR AU - Opsenica, Igor AU - Opsenica, Dejan AU - Jadranin, Milka AU - Smith, Kirsten AU - Milhous, Wilbur K. AU - Stratakis, Manolis AU - Šolaja, Bogdan PY - 2007 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/303 AB - Several dicyclohexylidene tetraoxanes were prepared in order to gain a further insight into structure-activity relationship of this kind of antimalarials. The tetraoxanes 2-5, obtained as a cis/trans mixture, showed pronounced antimalarial activity against Plasmodium falciparum chloroquine susceptible D6, chloroquine resistant W2 and multidrug-resistant TM91C235 (Thailand) strains. They have better than or similar activity to the corresponding desmethyl dicyclohexylidene derivatives. Two chimeric endoperoxides with superior antimalarial activity to the natural product ascaridole were also synthesized. AB - U ovom radu prikazana je sinteza nekoliko dicikiloheksilidenskih tetraoksana u cilju sagledavanja odnosa struktura-aktivnost ove vrste antimalarika. Jedinjenja 2-5 dobijena kao (cis,trans)-smese pokazala su izraženu antimalarijsku aktivnost prema D6, W2 i TM91C235 (Thailand) sojevima P. falciparum. Ona imaju bolju ili sličnu aktivnost od odgovarajućih desmetil cikloheksilidenskih derivata. Sintetisana su i dva endoperoksida himerne strukture znatno izraženije aktivnosti od prirodnog proizvoda askaridola. . PB - Serbian Chemical Society T2 - Journal of the Serbian Chemical Society T1 - On peroxide antimalarials T1 - O peroksidnim antimalaricima VL - 72 IS - 12 SP - 1181 EP - 1190 DO - 10.2298/JSC0712181O ER -
@article{ author = "Opsenica, Igor and Opsenica, Dejan and Jadranin, Milka and Smith, Kirsten and Milhous, Wilbur K. and Stratakis, Manolis and Šolaja, Bogdan", year = "2007", abstract = "Several dicyclohexylidene tetraoxanes were prepared in order to gain a further insight into structure-activity relationship of this kind of antimalarials. The tetraoxanes 2-5, obtained as a cis/trans mixture, showed pronounced antimalarial activity against Plasmodium falciparum chloroquine susceptible D6, chloroquine resistant W2 and multidrug-resistant TM91C235 (Thailand) strains. They have better than or similar activity to the corresponding desmethyl dicyclohexylidene derivatives. Two chimeric endoperoxides with superior antimalarial activity to the natural product ascaridole were also synthesized., U ovom radu prikazana je sinteza nekoliko dicikiloheksilidenskih tetraoksana u cilju sagledavanja odnosa struktura-aktivnost ove vrste antimalarika. Jedinjenja 2-5 dobijena kao (cis,trans)-smese pokazala su izraženu antimalarijsku aktivnost prema D6, W2 i TM91C235 (Thailand) sojevima P. falciparum. Ona imaju bolju ili sličnu aktivnost od odgovarajućih desmetil cikloheksilidenskih derivata. Sintetisana su i dva endoperoksida himerne strukture znatno izraženije aktivnosti od prirodnog proizvoda askaridola. .", publisher = "Serbian Chemical Society", journal = "Journal of the Serbian Chemical Society", title = "On peroxide antimalarials, O peroksidnim antimalaricima", volume = "72", number = "12", pages = "1181-1190", doi = "10.2298/JSC0712181O" }
Opsenica, I., Opsenica, D., Jadranin, M., Smith, K., Milhous, W. K., Stratakis, M.,& Šolaja, B.. (2007). On peroxide antimalarials. in Journal of the Serbian Chemical Society Serbian Chemical Society., 72(12), 1181-1190. https://doi.org/10.2298/JSC0712181O
Opsenica I, Opsenica D, Jadranin M, Smith K, Milhous WK, Stratakis M, Šolaja B. On peroxide antimalarials. in Journal of the Serbian Chemical Society. 2007;72(12):1181-1190. doi:10.2298/JSC0712181O .
Opsenica, Igor, Opsenica, Dejan, Jadranin, Milka, Smith, Kirsten, Milhous, Wilbur K., Stratakis, Manolis, Šolaja, Bogdan, "On peroxide antimalarials" in Journal of the Serbian Chemical Society, 72, no. 12 (2007):1181-1190, https://doi.org/10.2298/JSC0712181O . .