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Individual effects of different selenocompounds on the hepatic proteome and energy metabolism of mice

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2017
08_10072019_10.1016j.bbagen.2016.08.015.pdf (1.026Mb)
Authors
Lennicke, Claudia
Rahn, Jette
Kipp, Anna P.
Dojčinović, Biljana
Mueler, Andreas S.
Wessjohann, Ludger A.
Lichtenfels, Rudolf
Seliger, Barbara
Article (Accepted Version)
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Abstract
Background: Selenium (Se) exerts its biological activity largely via selenoproteins, which are key enzymes for maintaining the cellular redox homeostasis. However, besides these beneficial effects there is also evidence that an oversupply of Se might increase the risk towards developing metabolic disorders. To address this in more detail, we directly compared effects of feeding distinct Se compounds and concentrations on hepatic metabolism and expression profiles of mice. Methods: Male C57BL6/J mice received either a selenium-deficient diet or diets enriched with adequate or high doses of selenite, selenate or selenomethionine for 20 weeks. Subsequently, metabolic parameters, enzymatic activities and expression levels of hepatic selenoproteins, Nrf2 targets, and additional redox-sensitive proteins were analyzed. Furthermore, 2D-DIGE-based proteomic profiling revealed Se compound-specific differentially expressed proteins. Results: Whereas heterogeneous effects between high concentratio...ns of the Se compounds were observed with regard to body weight and metabolic activities, selenoproteins were only marginally increased by high Se concentrations in comparison to the respective adequate feeding. In particular the high-SeMet group showed a unique response compromising higher hepatic Se levels in comparison to all other groups. Accordingly, hepatic glutathione (GSH) levels, glutathione S-transferase (GST) activity, and GSTpi1 expression were comparably high in the high-SeMet and Se-deficient group, indicating that compound-specific effects of high doses appear to be independent of selenoproteins. Conclusions: Not only the nature, but also the concentration of Se compounds differentially affect biological processes. General significance: Thus, it is important to consider Se compound-specific effects when supplementing with selenium.

Keywords:
Selenium / Liver / Redox status / Energy metabolism
Source:
Biochimica et Biophysica Acta-General Subjects, 2017, 1861, 1, 3323-3334
Publisher:
  • Elsevier
Funding / projects:
  • DFG - LI1527/3-1
  • DFG - WE1467/13-1
  • DFG - MU3275/3-1
  • Application of advanced oxidation processes and nanostructured oxide materials for the removal of pollutants from the environment, development and optimisation of instrumental techniques for efficiency monitoring (RS-172030)
Note:
  • This is peer-reviewed version of the article: Claudia Lennicke, Jette Rahn, Anna P. Kipp, Biljana P. Dojcinovic, Andreas S. Muller, Ludger A. Wessjohann, Rudolf Lichtenfels, Barbara Seliger, Individual effects of different selenocompounds on the hepatic proteome and energy metabolism of mice, BBA - General Subjects (2016), Biochimica et Biophysica Acta-General Subjects, 2017, 1861, 1, 3323-3334 https://dx.doi.org/10.1016/j.bbagen.2016.08.015
  • http://cer.ihtm.bg.ac.rs/handle/123456789/2061

DOI: 10.1016/j.bbagen.2016.08.015

ISSN: 0304-4165

PubMed: 27565357

WoS: 000390736300038

Scopus: 2-s2.0-84995529961
[ Google Scholar ]
25
19
URI
https://cer.ihtm.bg.ac.rs/handle/123456789/3035
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
IHTM
TY  - JOUR
AU  - Lennicke, Claudia
AU  - Rahn, Jette
AU  - Kipp, Anna P.
AU  - Dojčinović, Biljana
AU  - Mueler, Andreas S.
AU  - Wessjohann, Ludger A.
AU  - Lichtenfels, Rudolf
AU  - Seliger, Barbara
PY  - 2017
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/3035
AB  - Background: Selenium (Se) exerts its biological activity largely via selenoproteins, which are key enzymes for maintaining the cellular redox homeostasis. However, besides these beneficial effects there is also evidence that an oversupply of Se might increase the risk towards developing metabolic disorders. To address this in more detail, we directly compared effects of feeding distinct Se compounds and concentrations on hepatic metabolism and expression profiles of mice. Methods: Male C57BL6/J mice received either a selenium-deficient diet or diets enriched with adequate or high doses of selenite, selenate or selenomethionine for 20 weeks. Subsequently, metabolic parameters, enzymatic activities and expression levels of hepatic selenoproteins, Nrf2 targets, and additional redox-sensitive proteins were analyzed. Furthermore, 2D-DIGE-based proteomic profiling revealed Se compound-specific differentially expressed proteins. Results: Whereas heterogeneous effects between high concentrations of the Se compounds were observed with regard to body weight and metabolic activities, selenoproteins were only marginally increased by high Se concentrations in comparison to the respective adequate feeding. In particular the high-SeMet group showed a unique response compromising higher hepatic Se levels in comparison to all other groups. Accordingly, hepatic glutathione (GSH) levels, glutathione S-transferase (GST) activity, and GSTpi1 expression were comparably high in the high-SeMet and Se-deficient group, indicating that compound-specific effects of high doses appear to be independent of selenoproteins. Conclusions: Not only the nature, but also the concentration of Se compounds differentially affect biological processes. General significance: Thus, it is important to consider Se compound-specific effects when supplementing with selenium.
PB  - Elsevier
T2  - Biochimica et Biophysica Acta-General Subjects
T1  - Individual effects of different selenocompounds on the hepatic proteome and energy metabolism of mice
VL  - 1861
IS  - 1
SP  - 3323
EP  - 3334
DO  - 10.1016/j.bbagen.2016.08.015
ER  - 
@article{
author = "Lennicke, Claudia and Rahn, Jette and Kipp, Anna P. and Dojčinović, Biljana and Mueler, Andreas S. and Wessjohann, Ludger A. and Lichtenfels, Rudolf and Seliger, Barbara",
year = "2017",
abstract = "Background: Selenium (Se) exerts its biological activity largely via selenoproteins, which are key enzymes for maintaining the cellular redox homeostasis. However, besides these beneficial effects there is also evidence that an oversupply of Se might increase the risk towards developing metabolic disorders. To address this in more detail, we directly compared effects of feeding distinct Se compounds and concentrations on hepatic metabolism and expression profiles of mice. Methods: Male C57BL6/J mice received either a selenium-deficient diet or diets enriched with adequate or high doses of selenite, selenate or selenomethionine for 20 weeks. Subsequently, metabolic parameters, enzymatic activities and expression levels of hepatic selenoproteins, Nrf2 targets, and additional redox-sensitive proteins were analyzed. Furthermore, 2D-DIGE-based proteomic profiling revealed Se compound-specific differentially expressed proteins. Results: Whereas heterogeneous effects between high concentrations of the Se compounds were observed with regard to body weight and metabolic activities, selenoproteins were only marginally increased by high Se concentrations in comparison to the respective adequate feeding. In particular the high-SeMet group showed a unique response compromising higher hepatic Se levels in comparison to all other groups. Accordingly, hepatic glutathione (GSH) levels, glutathione S-transferase (GST) activity, and GSTpi1 expression were comparably high in the high-SeMet and Se-deficient group, indicating that compound-specific effects of high doses appear to be independent of selenoproteins. Conclusions: Not only the nature, but also the concentration of Se compounds differentially affect biological processes. General significance: Thus, it is important to consider Se compound-specific effects when supplementing with selenium.",
publisher = "Elsevier",
journal = "Biochimica et Biophysica Acta-General Subjects",
title = "Individual effects of different selenocompounds on the hepatic proteome and energy metabolism of mice",
volume = "1861",
number = "1",
pages = "3323-3334",
doi = "10.1016/j.bbagen.2016.08.015"
}
Lennicke, C., Rahn, J., Kipp, A. P., Dojčinović, B., Mueler, A. S., Wessjohann, L. A., Lichtenfels, R.,& Seliger, B.. (2017). Individual effects of different selenocompounds on the hepatic proteome and energy metabolism of mice. in Biochimica et Biophysica Acta-General Subjects
Elsevier., 1861(1), 3323-3334.
https://doi.org/10.1016/j.bbagen.2016.08.015
Lennicke C, Rahn J, Kipp AP, Dojčinović B, Mueler AS, Wessjohann LA, Lichtenfels R, Seliger B. Individual effects of different selenocompounds on the hepatic proteome and energy metabolism of mice. in Biochimica et Biophysica Acta-General Subjects. 2017;1861(1):3323-3334.
doi:10.1016/j.bbagen.2016.08.015 .
Lennicke, Claudia, Rahn, Jette, Kipp, Anna P., Dojčinović, Biljana, Mueler, Andreas S., Wessjohann, Ludger A., Lichtenfels, Rudolf, Seliger, Barbara, "Individual effects of different selenocompounds on the hepatic proteome and energy metabolism of mice" in Biochimica et Biophysica Acta-General Subjects, 1861, no. 1 (2017):3323-3334,
https://doi.org/10.1016/j.bbagen.2016.08.015 . .

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