Quantitative analysis of sesquiterpene lactone cnicin in seven Centaurea species wild-growing in Serbia and Montenegro using 1H-NMR spectroscopy
Kvantitativna analiza seskviterpenskog laktona knicina u sedam samoniklih biljnih vrsta roda Centaurea, koje rastu u Srbiji i Crnoj Gori, korišćenjem 1H-NMR

2007
Authors
Tešević, Vele
Milosavljević, Slobodan

Vajs, Vlatka
Janaćković, Peđa
Đorđević, Iris

Jadranin, Milka

Vučković, Ivan

Article (Published version)
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1H-NMR spectroscopy was applied for the quantitative analysis of cnicin, a bioactive germacranolide type sesquiterpene lactone, in the aerial parts of seven wild-growing Centaurea species collected in Serbia and Montenegro. The analysis was performed by comparison of the integral of the one-proton signal of cnicin (H-13, δ 5.75) with that of the two-proton singlet ( δ 6.98) of 2,6-bis(1,1-dimethylethyl)-4-methylphenol (BHT), used as the internal standard. Cnicin, within the concentration range 1.06-6.12 mg/g, calculated per weight of the fresh plant material was detected in six species, the exception being C. salonitana. This method allows the rapid and simple quantification of cnicin without any pre-purification step.
1H-NMR spektrometrija je primenjena za kvantitativnu analizu knicina, bioaktivnog seskviterpenskog laktona germakranolidnog tipa, u nadzemnom delu sedam samoniklih biljnih vrsta roda Centaurea sakupljenih u Srbiji i Crnoj Gori. Analiza je izvršena poređenjem integrala signala jednog protona knicina (H-13, δ 5.75) sa singletom koji potiče od dva protona ( δ 6.98) internog standarda, 2,6-bis(1,1-dimetiletil)-4-metilfenola (BHT). Knicin je detektovan u svim vrstama, osim u C. salonitana, u koncentracijama u opsegu od 1,06 do 6,12 mg/g, računato na masu svežeg biljnog materijala. Ovaj metod omogućava brzu i jednostavnu kvantifikaciju knicina bez prethodnog prečišćavanja.
Keywords:
1H-NMR / Centaurea / cnicin / BHTSource:
Journal of the Serbian Chemical Society, 2007, 72, 12, 1275-1280Publisher:
- Serbian Chemical Society
Funding / projects:
- Sekundarni metaboliti samoniklih, lekovitih biljaka: izolovanje, karakterizacija i biloška aktivnost (RS-142053)
DOI: 10.2298/JSC0712275T
ISSN: 0352-5139
WoS: 000252412100012
Scopus: 2-s2.0-36949002290
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IHTMTY - JOUR AU - Tešević, Vele AU - Milosavljević, Slobodan AU - Vajs, Vlatka AU - Janaćković, Peđa AU - Đorđević, Iris AU - Jadranin, Milka AU - Vučković, Ivan PY - 2007 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/301 AB - 1H-NMR spectroscopy was applied for the quantitative analysis of cnicin, a bioactive germacranolide type sesquiterpene lactone, in the aerial parts of seven wild-growing Centaurea species collected in Serbia and Montenegro. The analysis was performed by comparison of the integral of the one-proton signal of cnicin (H-13, δ 5.75) with that of the two-proton singlet ( δ 6.98) of 2,6-bis(1,1-dimethylethyl)-4-methylphenol (BHT), used as the internal standard. Cnicin, within the concentration range 1.06-6.12 mg/g, calculated per weight of the fresh plant material was detected in six species, the exception being C. salonitana. This method allows the rapid and simple quantification of cnicin without any pre-purification step. AB - 1H-NMR spektrometrija je primenjena za kvantitativnu analizu knicina, bioaktivnog seskviterpenskog laktona germakranolidnog tipa, u nadzemnom delu sedam samoniklih biljnih vrsta roda Centaurea sakupljenih u Srbiji i Crnoj Gori. Analiza je izvršena poređenjem integrala signala jednog protona knicina (H-13, δ 5.75) sa singletom koji potiče od dva protona ( δ 6.98) internog standarda, 2,6-bis(1,1-dimetiletil)-4-metilfenola (BHT). Knicin je detektovan u svim vrstama, osim u C. salonitana, u koncentracijama u opsegu od 1,06 do 6,12 mg/g, računato na masu svežeg biljnog materijala. Ovaj metod omogućava brzu i jednostavnu kvantifikaciju knicina bez prethodnog prečišćavanja. PB - Serbian Chemical Society T2 - Journal of the Serbian Chemical Society T1 - Quantitative analysis of sesquiterpene lactone cnicin in seven Centaurea species wild-growing in Serbia and Montenegro using 1H-NMR spectroscopy T1 - Kvantitativna analiza seskviterpenskog laktona knicina u sedam samoniklih biljnih vrsta roda Centaurea, koje rastu u Srbiji i Crnoj Gori, korišćenjem 1H-NMR VL - 72 IS - 12 SP - 1275 EP - 1280 DO - 10.2298/JSC0712275T ER -
@article{ author = "Tešević, Vele and Milosavljević, Slobodan and Vajs, Vlatka and Janaćković, Peđa and Đorđević, Iris and Jadranin, Milka and Vučković, Ivan", year = "2007", abstract = "1H-NMR spectroscopy was applied for the quantitative analysis of cnicin, a bioactive germacranolide type sesquiterpene lactone, in the aerial parts of seven wild-growing Centaurea species collected in Serbia and Montenegro. The analysis was performed by comparison of the integral of the one-proton signal of cnicin (H-13, δ 5.75) with that of the two-proton singlet ( δ 6.98) of 2,6-bis(1,1-dimethylethyl)-4-methylphenol (BHT), used as the internal standard. Cnicin, within the concentration range 1.06-6.12 mg/g, calculated per weight of the fresh plant material was detected in six species, the exception being C. salonitana. This method allows the rapid and simple quantification of cnicin without any pre-purification step., 1H-NMR spektrometrija je primenjena za kvantitativnu analizu knicina, bioaktivnog seskviterpenskog laktona germakranolidnog tipa, u nadzemnom delu sedam samoniklih biljnih vrsta roda Centaurea sakupljenih u Srbiji i Crnoj Gori. Analiza je izvršena poređenjem integrala signala jednog protona knicina (H-13, δ 5.75) sa singletom koji potiče od dva protona ( δ 6.98) internog standarda, 2,6-bis(1,1-dimetiletil)-4-metilfenola (BHT). Knicin je detektovan u svim vrstama, osim u C. salonitana, u koncentracijama u opsegu od 1,06 do 6,12 mg/g, računato na masu svežeg biljnog materijala. Ovaj metod omogućava brzu i jednostavnu kvantifikaciju knicina bez prethodnog prečišćavanja.", publisher = "Serbian Chemical Society", journal = "Journal of the Serbian Chemical Society", title = "Quantitative analysis of sesquiterpene lactone cnicin in seven Centaurea species wild-growing in Serbia and Montenegro using 1H-NMR spectroscopy, Kvantitativna analiza seskviterpenskog laktona knicina u sedam samoniklih biljnih vrsta roda Centaurea, koje rastu u Srbiji i Crnoj Gori, korišćenjem 1H-NMR", volume = "72", number = "12", pages = "1275-1280", doi = "10.2298/JSC0712275T" }
Tešević, V., Milosavljević, S., Vajs, V., Janaćković, P., Đorđević, I., Jadranin, M.,& Vučković, I.. (2007). Quantitative analysis of sesquiterpene lactone cnicin in seven Centaurea species wild-growing in Serbia and Montenegro using 1H-NMR spectroscopy. in Journal of the Serbian Chemical Society Serbian Chemical Society., 72(12), 1275-1280. https://doi.org/10.2298/JSC0712275T
Tešević V, Milosavljević S, Vajs V, Janaćković P, Đorđević I, Jadranin M, Vučković I. Quantitative analysis of sesquiterpene lactone cnicin in seven Centaurea species wild-growing in Serbia and Montenegro using 1H-NMR spectroscopy. in Journal of the Serbian Chemical Society. 2007;72(12):1275-1280. doi:10.2298/JSC0712275T .
Tešević, Vele, Milosavljević, Slobodan, Vajs, Vlatka, Janaćković, Peđa, Đorđević, Iris, Jadranin, Milka, Vučković, Ivan, "Quantitative analysis of sesquiterpene lactone cnicin in seven Centaurea species wild-growing in Serbia and Montenegro using 1H-NMR spectroscopy" in Journal of the Serbian Chemical Society, 72, no. 12 (2007):1275-1280, https://doi.org/10.2298/JSC0712275T . .