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Low-molecular-weight protease inhibitors of microbial origin

Niskomolekulski inhibitori proteaza mikrobnog porekla

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2001
28.pdf (315.9Kb)
Authors
Izrael, Lidija
Gojgić-Cvijović, Gordana
Karadžić, Ivanka
Article (Published version)
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Abstract
We have witnessed an explosion of informations about properties, also mode of action and regulation of proteases from the metalloproteases at the cell surface to the AIDS protease. Protease inhibitors have a great importance in mechanism of proteolysis. One of the latest strategies to combat diseases like AIDS and cancer is to use proteinase inhibitors as drugs. Especially good source of protease inhibitors are microorganisms. A few low-molecular-weight proetease inhibitors of microbial origin, as a potential drugs, was described.
Budući da je upotreba inhibitora aminopetidaza u lečenju SIDE, takođe i kancera različitih vrsta, tzv. nova strategija u lečenju ovih bolesti [18] to je u toku traženje novih inhibitora AP a posebno LAP kao proizvoda metabolizma mikroorganizama, ali i stereoselektivna sinteza jedinjenja koja su im slična [19]. Može se pretpostaviti da će sledećih godina napredak u biohemiji patoloških procesa biti pod velikim uticajem napretka u istraživanju niskomolekulskih inhibitora koje produkuju mikroorganizmi ali i napretka u sintezi analoga ovih jedinjenja.
Source:
Hemijski pregled, 2001, 42, 1, 4-9
Publisher:
  • Srpsko hemijsko društvo, Beograd

ISSN: 0440-6826

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URI
http://cer.ihtm.bg.ac.rs/handle/123456789/30
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