We have witnessed an explosion of informations about properties, also mode of action and regulation of proteases from the metalloproteases at the cell surface to the AIDS protease. Protease inhibitors have a great importance in mechanism of proteolysis. One of the latest strategies to combat diseases like AIDS and cancer is to use proteinase inhibitors as drugs. Especially good source of protease inhibitors are microorganisms. A few low-molecular-weight proetease inhibitors of microbial origin, as a potential drugs, was described.
Budući da je upotreba inhibitora aminopetidaza u lečenju SIDE, takođe i kancera različitih vrsta, tzv. nova strategija u lečenju ovih bolesti [18] to je u toku traženje novih inhibitora AP a posebno LAP kao proizvoda metabolizma mikroorganizama, ali i stereoselektivna sinteza jedinjenja koja su im slična [19]. Može se pretpostaviti da će sledećih godina napredak u biohemiji patoloških procesa biti pod velikim uticajem napretka u istraživanju niskomolekulskih inhibitora koje produkuju mikroorganizmi ali i napretka u sintezi analoga ovih jedinjenja.
TY - JOUR
AU - Izrael, Lidija
AU - Gojgić-Cvijović, Gordana
AU - Karadžić, Ivanka
PY - 2001
UR - http://cer.ihtm.bg.ac.rs/handle/123456789/30
AB - We have witnessed an explosion of informations about properties, also mode of action and regulation of proteases from the metalloproteases at the cell surface to the AIDS protease. Protease inhibitors have a great importance in mechanism of proteolysis. One of the latest strategies to combat diseases like AIDS and cancer is to use proteinase inhibitors as drugs. Especially good source of protease inhibitors are microorganisms. A few low-molecular-weight proetease inhibitors of microbial origin, as a potential drugs, was described.
AB - Budući da je upotreba inhibitora aminopetidaza u lečenju SIDE, takođe i kancera različitih vrsta, tzv. nova strategija u lečenju ovih bolesti [18] to je u toku traženje novih inhibitora AP a posebno LAP kao proizvoda metabolizma mikroorganizama, ali i stereoselektivna sinteza jedinjenja koja su im slična [19]. Može se pretpostaviti da će sledećih godina napredak u biohemiji patoloških procesa biti pod velikim uticajem napretka u istraživanju niskomolekulskih inhibitora koje produkuju mikroorganizmi ali i napretka u sintezi analoga ovih jedinjenja.
PB - Srpsko hemijsko društvo, Beograd
T2 - Hemijski pregled
T1 - Low-molecular-weight protease inhibitors of microbial origin
T1 - Niskomolekulski inhibitori proteaza mikrobnog porekla
VL - 42
IS - 1
SP - 4
EP - 9
ER -
@article{
author = "Izrael, Lidija and Gojgić-Cvijović, Gordana and Karadžić, Ivanka",
year = "2001",
url = "http://cer.ihtm.bg.ac.rs/handle/123456789/30",
abstract = "We have witnessed an explosion of informations about properties, also mode of action and regulation of proteases from the metalloproteases at the cell surface to the AIDS protease. Protease inhibitors have a great importance in mechanism of proteolysis. One of the latest strategies to combat diseases like AIDS and cancer is to use proteinase inhibitors as drugs. Especially good source of protease inhibitors are microorganisms. A few low-molecular-weight proetease inhibitors of microbial origin, as a potential drugs, was described., Budući da je upotreba inhibitora aminopetidaza u lečenju SIDE, takođe i kancera različitih vrsta, tzv. nova strategija u lečenju ovih bolesti [18] to je u toku traženje novih inhibitora AP a posebno LAP kao proizvoda metabolizma mikroorganizama, ali i stereoselektivna sinteza jedinjenja koja su im slična [19]. Može se pretpostaviti da će sledećih godina napredak u biohemiji patoloških procesa biti pod velikim uticajem napretka u istraživanju niskomolekulskih inhibitora koje produkuju mikroorganizmi ali i napretka u sintezi analoga ovih jedinjenja.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Hemijski pregled",
title = "Low-molecular-weight protease inhibitors of microbial origin, Niskomolekulski inhibitori proteaza mikrobnog porekla",
volume = "42",
number = "1",
pages = "4-9"
}
