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dc.creatorStanković, Jovana
dc.creatorGođevac, Dejan
dc.creatorTešević, Vele
dc.creatorDajić-Stevanović, Zora
dc.creatorĆirić, Ana
dc.creatorSoković, Marina
dc.creatorNovaković, Miroslav
dc.date.accessioned2019-07-02T12:24:39Z
dc.date.available2019-07-02T12:24:39Z
dc.date.issued2019
dc.identifier.issn0163-3864
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/2995
dc.description.abstractA new flavonoid glucoside derivative, patuletin 3-O-(2-O-feruloyl)-β-D-glucuronopyranosyl-(1→2)-β-Dglucopyranoside, named atriplexin IV (1), and three new triterpenoid saponin derivatives, two sulfonylated, β-Dglucopyranosyl-3-O-(2-O-sulfo-β-D-galactopyranosyl)-(1→2)-α-L arabinopyranoside-30-alolean-12-en-28-oate (2), named atriplexogenin I, β-D-glucopyranosyl-3-O-(2-O-sulfo-β-D-galactopyranosyl)-(1→2)-α-L-arabinopyranoside)-30-hydroxyolean-12-en- 28-oate (3), named atriplexogenin II, and β-D-glucopyranosyl-3-O-(β-D-glucopyranosyl-(1→2)-β-D-galactopyranosyl-(1→2)-α-L-arabinopyranoside)-30-alolean-12-en-28-oate (4), named atriplexogenin III, were isolated by silica gel column and semipreparative HPLC chromatography from the n-butanol extract of the salt marsh plant Atriplex tatarica. In addition, two known secondary metabolites, patuletin3-O-β-D-apiofuranosyl-(1‴→2″)-β-D-glucopyranoside (5) and patuletin 3-O-5‴-Oferuloyl-β-D-apiofuranosyl-(1‴→2″)-β-D-glucopyranoside (6), were isolated for the first time from A. tatarica. The structures of the isolated compounds were elucidated by 1D and 2D NMR, HRESIMS, IR, and UV data. Antibacterial activity by the microdilution method and antibiofilm activity against P. aeruginosa were assessed. Compound 5 possesses significant antibacterial activity, while the most potent antibiofilm agent is compound 2.en
dc.language.isoensr
dc.publisherAmerican Chemical Society (ACS)sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173032/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/31089/RS//
dc.rightsrestrictedAccesssr
dc.sourceJournal of Natural Productssr
dc.titleAntibacterial and Antibiofilm Activity of Flavonoid and Saponin Derivatives from Atriplex tatarica against Pseudomonas aeruginosaen
dc.typearticlesr
dc.rights.licenseARRsr
dcterms.abstractГођевац, Дејан; Новаковић, Мирослав; Соковић, Марина; Дајић-Стевановић, Зора; Тешевић, Веле; Ћирић, Aна; Станковић, Јована;
dc.rights.holderAmerican Chemical Society (ACS)sr
dc.citation.volume82
dc.citation.spage1487
dc.citation.epage1495
dc.citation.rankaM21~
dc.identifier.doi10.1021/acs.jnatprod.8b00970
dc.identifier.scopus2-s2.0-85067065776
dc.identifier.wos000473827300011
dc.type.versionpublishedVersionsr


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