Antibacterial and Antibiofilm Activity of Flavonoid and Saponin Derivatives from Atriplex tatarica against Pseudomonas aeruginosa
Samo za registrovane korisnike
2019
Autori
Stanković, Jovana
Gođevac, Dejan

Tešević, Vele

Dajić-Stevanović, Zora

Ćirić, Ana
Soković, Marina

Novaković, Miroslav

Članak u časopisu (Objavljena verzija)

American Chemical Society (ACS)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
A new flavonoid glucoside derivative, patuletin 3-O-(2-O-feruloyl)-β-D-glucuronopyranosyl-(1→2)-β-Dglucopyranoside, named atriplexin IV (1), and three new triterpenoid saponin derivatives, two sulfonylated, β-Dglucopyranosyl-3-O-(2-O-sulfo-β-D-galactopyranosyl)-(1→2)-α-L arabinopyranoside-30-alolean-12-en-28-oate (2), named atriplexogenin I, β-D-glucopyranosyl-3-O-(2-O-sulfo-β-D-galactopyranosyl)-(1→2)-α-L-arabinopyranoside)-30-hydroxyolean-12-en-
28-oate (3), named atriplexogenin II, and β-D-glucopyranosyl-3-O-(β-D-glucopyranosyl-(1→2)-β-D-galactopyranosyl-(1→2)-α-L-arabinopyranoside)-30-alolean-12-en-28-oate (4), named atriplexogenin III, were isolated by silica gel column and semipreparative HPLC chromatography from the n-butanol extract of the salt marsh plant Atriplex tatarica. In addition, two known secondary metabolites, patuletin3-O-β-D-apiofuranosyl-(1‴→2″)-β-D-glucopyranoside (5) and patuletin 3-O-5‴-Oferuloyl-β-D-apiofuranosyl-(1‴→2″)-β-D-glucopyranoside (6), were isolated ...for the first time from A. tatarica. The structures of the isolated compounds were elucidated by 1D and 2D NMR, HRESIMS, IR, and UV data. Antibacterial activity by the microdilution method and antibiofilm activity against P. aeruginosa were assessed. Compound 5 possesses significant
antibacterial activity, while the most potent antibiofilm agent is compound 2.
Izvor:
Journal of Natural Products, 2019, 82, 1487-1495Izdavač:
- American Chemical Society (ACS)
Finansiranje / projekti:
- Bioaktivni prirodni proizvodi samoniklih, gajenih i jestivih biljaka: određivanje struktura i aktivnosti (RS-172053)
- Karakterizacija i primena metabolita gljiva i utvrđivanje potencijala novih biofungicida (RS-173032)
- Morfološka, hemijska, farmakološka i agronomska karakterizacija panonskog timijana (Thymus pannonicus All., Lamiaceae), sa ciljem njegove održive proizvodnje u intenzivnom sistemu ratarenja (RS-31089)
DOI: 10.1021/acs.jnatprod.8b00970
ISSN: 0163-3864
WoS: 000473827300011
Scopus: 2-s2.0-85067065776
Institucija/grupa
IHTMTY - JOUR AU - Stanković, Jovana AU - Gođevac, Dejan AU - Tešević, Vele AU - Dajić-Stevanović, Zora AU - Ćirić, Ana AU - Soković, Marina AU - Novaković, Miroslav PY - 2019 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/2995 AB - A new flavonoid glucoside derivative, patuletin 3-O-(2-O-feruloyl)-β-D-glucuronopyranosyl-(1→2)-β-Dglucopyranoside, named atriplexin IV (1), and three new triterpenoid saponin derivatives, two sulfonylated, β-Dglucopyranosyl-3-O-(2-O-sulfo-β-D-galactopyranosyl)-(1→2)-α-L arabinopyranoside-30-alolean-12-en-28-oate (2), named atriplexogenin I, β-D-glucopyranosyl-3-O-(2-O-sulfo-β-D-galactopyranosyl)-(1→2)-α-L-arabinopyranoside)-30-hydroxyolean-12-en- 28-oate (3), named atriplexogenin II, and β-D-glucopyranosyl-3-O-(β-D-glucopyranosyl-(1→2)-β-D-galactopyranosyl-(1→2)-α-L-arabinopyranoside)-30-alolean-12-en-28-oate (4), named atriplexogenin III, were isolated by silica gel column and semipreparative HPLC chromatography from the n-butanol extract of the salt marsh plant Atriplex tatarica. In addition, two known secondary metabolites, patuletin3-O-β-D-apiofuranosyl-(1‴→2″)-β-D-glucopyranoside (5) and patuletin 3-O-5‴-Oferuloyl-β-D-apiofuranosyl-(1‴→2″)-β-D-glucopyranoside (6), were isolated for the first time from A. tatarica. The structures of the isolated compounds were elucidated by 1D and 2D NMR, HRESIMS, IR, and UV data. Antibacterial activity by the microdilution method and antibiofilm activity against P. aeruginosa were assessed. Compound 5 possesses significant antibacterial activity, while the most potent antibiofilm agent is compound 2. PB - American Chemical Society (ACS) T2 - Journal of Natural Products T1 - Antibacterial and Antibiofilm Activity of Flavonoid and Saponin Derivatives from Atriplex tatarica against Pseudomonas aeruginosa VL - 82 SP - 1487 EP - 1495 DO - 10.1021/acs.jnatprod.8b00970 ER -
@article{ author = "Stanković, Jovana and Gođevac, Dejan and Tešević, Vele and Dajić-Stevanović, Zora and Ćirić, Ana and Soković, Marina and Novaković, Miroslav", year = "2019", abstract = "A new flavonoid glucoside derivative, patuletin 3-O-(2-O-feruloyl)-β-D-glucuronopyranosyl-(1→2)-β-Dglucopyranoside, named atriplexin IV (1), and three new triterpenoid saponin derivatives, two sulfonylated, β-Dglucopyranosyl-3-O-(2-O-sulfo-β-D-galactopyranosyl)-(1→2)-α-L arabinopyranoside-30-alolean-12-en-28-oate (2), named atriplexogenin I, β-D-glucopyranosyl-3-O-(2-O-sulfo-β-D-galactopyranosyl)-(1→2)-α-L-arabinopyranoside)-30-hydroxyolean-12-en- 28-oate (3), named atriplexogenin II, and β-D-glucopyranosyl-3-O-(β-D-glucopyranosyl-(1→2)-β-D-galactopyranosyl-(1→2)-α-L-arabinopyranoside)-30-alolean-12-en-28-oate (4), named atriplexogenin III, were isolated by silica gel column and semipreparative HPLC chromatography from the n-butanol extract of the salt marsh plant Atriplex tatarica. In addition, two known secondary metabolites, patuletin3-O-β-D-apiofuranosyl-(1‴→2″)-β-D-glucopyranoside (5) and patuletin 3-O-5‴-Oferuloyl-β-D-apiofuranosyl-(1‴→2″)-β-D-glucopyranoside (6), were isolated for the first time from A. tatarica. The structures of the isolated compounds were elucidated by 1D and 2D NMR, HRESIMS, IR, and UV data. Antibacterial activity by the microdilution method and antibiofilm activity against P. aeruginosa were assessed. Compound 5 possesses significant antibacterial activity, while the most potent antibiofilm agent is compound 2.", publisher = "American Chemical Society (ACS)", journal = "Journal of Natural Products", title = "Antibacterial and Antibiofilm Activity of Flavonoid and Saponin Derivatives from Atriplex tatarica against Pseudomonas aeruginosa", volume = "82", pages = "1487-1495", doi = "10.1021/acs.jnatprod.8b00970" }
Stanković, J., Gođevac, D., Tešević, V., Dajić-Stevanović, Z., Ćirić, A., Soković, M.,& Novaković, M.. (2019). Antibacterial and Antibiofilm Activity of Flavonoid and Saponin Derivatives from Atriplex tatarica against Pseudomonas aeruginosa. in Journal of Natural Products American Chemical Society (ACS)., 82, 1487-1495. https://doi.org/10.1021/acs.jnatprod.8b00970
Stanković J, Gođevac D, Tešević V, Dajić-Stevanović Z, Ćirić A, Soković M, Novaković M. Antibacterial and Antibiofilm Activity of Flavonoid and Saponin Derivatives from Atriplex tatarica against Pseudomonas aeruginosa. in Journal of Natural Products. 2019;82:1487-1495. doi:10.1021/acs.jnatprod.8b00970 .
Stanković, Jovana, Gođevac, Dejan, Tešević, Vele, Dajić-Stevanović, Zora, Ćirić, Ana, Soković, Marina, Novaković, Miroslav, "Antibacterial and Antibiofilm Activity of Flavonoid and Saponin Derivatives from Atriplex tatarica against Pseudomonas aeruginosa" in Journal of Natural Products, 82 (2019):1487-1495, https://doi.org/10.1021/acs.jnatprod.8b00970 . .