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dc.creatorČairović, Aleksandra D.
dc.creatorStanimirović, Dragan D.
dc.creatorKrajnović, Tamara T.
dc.creatorDojčinović, Biljana
dc.creatorMaksimović, Vesna M.
dc.creatorCvijović-Alagić, Ivana Lj.
dc.date.accessioned2019-07-02T12:04:13Z
dc.date.available2019-07-02T12:04:13Z
dc.date.issued2019
dc.identifier.issn1821-4339
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/2993
dc.description.abstractThe biological quality and chemical composition of alloys used in dental practice change during heat treatment. Often the residues of the previous cast are not disposed of but are reused and recycled until consumed. Thus, manufactured dental restorations have modified biological quality and chemical composition, and compromised biocompatibility. The aim of this study was to investigate the influence of repeated casting on the cytotoxicity of the silver-palladium (Ag-Pd) alloy. Our results showed that repeated casting of the Ag-Pd dental alloy affected its biocompatibility by promoting toxicity against transformed fibroblasts in a contact-independent manner. A strong decrease in cell proliferation, induction of senescence and massive cell death were observed in cultures exposed only to a medium previously incubated with dental alloy samples. The obtained data indicated that toxicity mediated by the accumulation of the Ag, Pd, Cu and Zn cations released from the Ag-Pd material was enhanced by recasting. The induction of cell senescence and subsequent apoptotic and necrotic death were accompanied by amplified intracellular production of reactive oxygen and nitrogen species, suggesting their involvement in the cell destruction process. Therefore, compromised biocompatibility after recasting with the Ag-Pd alloy can be the cause of serious local cell destruction, as observed in clinical practice.sr
dc.language.isoensr
dc.publisherSerbian Biological Societysr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45012/RS//sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173013/RS//sr
dc.rightsopenAccesssr
dc.sourceArchives of Biological Sciencessr
dc.subjectdental alloyssr
dc.subjectcytotoxicitysr
dc.subjectnecrosissr
dc.subjectrecastingsr
dc.subjectreactive oxygen speciessr
dc.titleRecasting as a booster of Ag-Pd alloy cytotoxicity: induction of cell senescence prior to mass cell deathsr
dc.typearticlesr
dc.rights.licenseBY-NC-NDsr
dc.rights.holderSerbian Biological Societysr
dc.citation.volume71
dc.citation.issue2
dc.citation.spage347
dc.citation.epage356
dc.citation.rankM23~
dc.identifier.doi10.2298/ABS190305017C
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs//bitstream/id/7347/0354-46641900017C.pdf
dc.identifier.scopus2-s2.0-85067112829
dc.identifier.wos000471069700017
dc.type.versionpublishedVersionsr


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