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dc.creatorKozarski, Maja S.
dc.creatorKlaus, Anita
dc.creatorJakovljević, Dragica
dc.creatorTodorović, Nina
dc.creatorWan Abd Al Qadr Imad, Wan-Mohtar
dc.creatorNikšić, Miomir
dc.date.accessioned2019-07-02T11:48:29Z
dc.date.available2019-07-02T11:48:29Z
dc.date.issued2019
dc.identifier.issn0354-4664
dc.identifier.issn1821-4339
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/2992
dc.description.abstractThree different polysaccharide extracts of a wild European source of the mushroom Ganoderma lucidum were screened for their free radical-blocking potential, which could strengthen the skin’s barrier function, and provide a skinlightening effect via potential inhibition of tyrosinase. The anti-collagenase and anti-elastase activities, which can help to restore skin elasticity and tensile strength, were also evaluated for the three extracts. Carbohydrates were the most abundant components of the extracts, followed by smaller quantities of proteins, phenols and flavonoids. The glucan fraction represented between 48% and 61% of carbohydrate content in all three extracts. None of the analyzed extracts showed overt toxicity to spontaneously-transformed immortal human keratinocytes (HaCaT) at concentrations up to 2 mg/mL, and displayed superior scavenging ability on 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals. The hot water crude polysaccharide extract (HWCP) and partially purified fraction (HWPP) were found to be effective inhibitors of lipid peroxidation (LPx), with an almost two-fold increased inhibition of LPx compared with ascorbic acid (EC50=1.65±0.08 mg/mL), a common additive in cosmeceutical formulations and used at mg levels. Among the investigated extracts, HWCP showed the strongest inhibition potential on tyrosinase and skin extracellular matrix (ECM) degradation enzymes. These diverse functionalities indicate that G. lucidum may represent a promising source of natural cosmeceutical ingredients.en
dc.language.isoensr
dc.publisherSerbian Biological Societysr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46001/RS//sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46010/RS//sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/43004/RS//sr
dc.rightsopenAccesssr
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceArchives of Biological Sciencessr
dc.subjectGanoderma lucidumsr
dc.subjectcosmeceuticalsr
dc.subjectmaturate skinsr
dc.subjectoxidative stresssr
dc.subjectpolysaccharide extractssr
dc.titleGanoderma lucidum as a cosmeceutical: antiradical potential and inhibitory effect on hyperpigmentation and skin extracellular matrix degradation enzymesen
dc.typearticlesr
dc.rights.licenseBY-NC-NDsr
dcterms.abstractWан Aбд Aл Qадр Имад, Wан-Мохтар; Козарски, Маја; Клаус, Aнита; Јаковљевић, Драгица; Тодоровић, Нина; Никшић, Миомир;
dc.rights.holderSerbian Biological Societysr
dc.citation.volume71
dc.citation.issue2
dc.citation.spage253
dc.citation.epage264
dc.citation.rankM23~
dc.identifier.doi10.2298/ABS181217007K
dc.identifier.fulltexthttps://cer.ihtm.bg.ac.rs//bitstream/id/7346/0354-46641900007K.pdf
dc.identifier.scopus2-s2.0-85067124763
dc.identifier.wos000471069700007
dc.type.versionpublishedVersionsr


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