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dc.creatorDimitrijević, Milena S.
dc.creatorBogdanović Pristov, Jelena
dc.creatorŽižić, Milan
dc.creatorStanković, Dalibor
dc.creatorBajuk-Bogdanović, Danica
dc.creatorStanić, Marina
dc.creatorSpasić, Snežana
dc.creatorHagen, Wilfred
dc.creatorSpasojević, Ivan
dc.date.accessioned2019-06-03T08:16:19Z
dc.date.available2019-06-03T08:16:19Z
dc.date.issued2019
dc.identifier.issn1477-9226
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/2932
dc.description.abstractBiliverdin (BV), a product of heme catabolism, is known to interact with transition metals, but the details of such interactions under physiological conditions are scarce. Herein, we examined coordinate/redox interactions of BV with Cu2+ in phosphate buffer at pH 7.4, using spectrophotometry, HESI-MS, Raman spectroscopy, 1 H NMR, EPR, fluorimetry, and electrochemical methods. BV formed a stable coordination complex with copper in 1 : 1 stoichiometry. The structure of BV was more planar and energetically stable in the complex. The complex showed strong paramagnetic effects that were attributed to an unpaired delocalized e−. The delocalized electron may come from BV or Cu2+, so the complex is formally composed either of BV radical cation and Cu1+ or of BV radical anion and Cu3+. The complex underwent oxidation only in the presence of both O2 and an excess of Cu2+, or a strong oxidizing agent, and it was resistant to reducing agents. The biological effects of the stable BV metallocomplex containing a delocalized unpaired electron should be further examined, and may provide an answer to the long-standing question of high energy investment in the catabolism of BV, which represents a relatively harmless molecule per se.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/43010/RS//
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/621375/EU//
dc.rightsrestrictedAccess
dc.sourceDalton Transactions
dc.titleBiliverdin-copper complex at physiological pHen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСпасић, Снежана; Димитријевић, Милена С.; Хаген, Wилфред; Спасојевић, Иван; Богдановић Пристов, Јелена; Жижић, Милан; Станковић, Далибор; Бајук-Богдановић, Даница; Станић, Марина;
dc.citation.volume48
dc.citation.issue18
dc.citation.spage6061
dc.citation.epage6070
dc.citation.rankM21~
dc.description.otherPeer-reviewed version: [http://cer.ihtm.bg.ac.rs/handle/123456789/2933]
dc.identifier.doi10.1039/c8dt04724c
dc.identifier.scopus2-s2.0-85065545631
dc.identifier.wos000472449300020
dc.type.versionpublishedVersion


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