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dc.creatorOzek, Gulmira
dc.creatorYur, Suleyman
dc.creatorGoger, Fatih
dc.creatorOzek, Temel
dc.creatorAnđelković, Boban D.
dc.creatorGođevac, Dejan
dc.creatorSofrenić, Ivana
dc.creatorAneva, Ina
dc.creatorTodorova, Milka
dc.creatorTrendafilova, Antoaneta
dc.date.accessioned2019-05-29T09:31:38Z
dc.date.available2020-01-31
dc.date.issued2019
dc.identifier.issn1612-1872
dc.identifier.issn1612-1880 (Online)
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/2869
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/2899
dc.description.abstractHexane extracts of Heracleum verticillatum, H. sibiricum, H. angustisectum, and H. ternatum were studied fortheir furanocoumarin content antioxidant potential and acetylcholinesterase and α-amylase inhibitory activities.Quantification of the furanocoumarins was performed by 1H-NMR. Pimpinellin was found to be the maincomponent in the roots of all studied species. Bergapten and imperatorin were the major compounds in thefruits of H. sibiricum and H. verticillatum, respectively, while byakangelicol dominated in H. angustisectum and H.ternatum fruits. The leaf and fruit extracts of H. angustisectum demonstrated the highest DPPH radical scavengingactivity and TEAC (IC50 0.58 mg/mL and 1.83 mM, respectively). The root extracts of H. verticillatum and H.angustisectum were found to be the most effective against acetylcholinesterase (IC50 0.30 and 0.34 mg/mL,respectively). The studied extracts were not active or demonstrated a weak inhibitory effect (%Inh. up to 29.7)towards α-amylase.sr
dc.language.isoensr
dc.publisherWilleysr
dc.relationTUBITAK, Project No. 116S021sr
dc.relationBilateral project between the Bulgarian Academy of Science and the Serbian Academy of Sciences and Artssr
dc.rightsembargoedAccesssr
dc.sourceChemistry and Biodiversitysr
dc.subjectHeracleum speciessr
dc.subjectfuranocoumarinssr
dc.subjectantioxidantssr
dc.subjectacetylcholinesterase inhibitionsr
dc.subjectantidiabetic activitysr
dc.titleFuranocoumarin Content, Antioxidant Activity, and Inhibitory Potential of Heracleum verticillatum, Heracleum sibiricum, Heracleum angustisectum, and Heracleum ternatum Extracts against Enzymes Involved in Alzheimer’s Disease and Type II Diabetessr
dc.typearticlesr
dc.rights.licenseBY-NC-NDsr
dcterms.abstractAнђелковић, Бобан Д.; Озек, Гулмира; Yур, Сулеyман; Гогер, Фатих; Озек, Темел; Гођевац, Дејан; Софренић, Ивана; Aнева, Ина; Тодорова, Милка; Трендафилова, Aнтоанета;
dc.citation.volume16
dc.citation.issue4
dc.citation.spagee1800672
dc.citation.rankM22~
dc.description.other[http://cer.ihtm.bg.ac.rs/handle/123456789/2869]
dc.identifier.doi10.1002/cbdv.201800672
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs/bitstream/id/7017/10.1002@cbdv.201800672.pdf
dc.identifier.scopus2-s2.0-85063580781
dc.identifier.wos000467184500017
dc.type.versionacceptedVersionsr


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