CER - Central Repository
Institute of Chemistry, Technology and Metallurgy
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrillic)
    • Serbian (Latin)
  • Login
View Item 
  •   CER
  • IHTM
  • Radovi istraživača / Researchers' publications
  • View Item
  •   CER
  • IHTM
  • Radovi istraživača / Researchers' publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Furanocoumarin Content, Antioxidant Activity, and Inhibitory Potential of Heracleum verticillatum, Heracleum sibiricum, Heracleum angustisectum, and Heracleum ternatum Extracts against Enzymes Involved in Alzheimer’s Disease and Type II Diabetes

Thumbnail
2019
10.1002@cbdv.201800672.pdf (4.395Mb)
Authors
Ozek, Gulmira
Yur, Suleyman
Goger, Fatih
Ozek, Temel
Anđelković, Boban D.
Gođevac, Dejan
Sofrenić, Ivana
Aneva, Ina
Todorova, Milka
Trendafilova, Antoaneta
Article (Accepted Version)
Metadata
Show full item record
Abstract
Hexane extracts of Heracleum verticillatum, H. sibiricum, H. angustisectum, and H. ternatum were studied fortheir furanocoumarin content antioxidant potential and acetylcholinesterase and α-amylase inhibitory activities.Quantification of the furanocoumarins was performed by 1H-NMR. Pimpinellin was found to be the maincomponent in the roots of all studied species. Bergapten and imperatorin were the major compounds in thefruits of H. sibiricum and H. verticillatum, respectively, while byakangelicol dominated in H. angustisectum and H.ternatum fruits. The leaf and fruit extracts of H. angustisectum demonstrated the highest DPPH radical scavengingactivity and TEAC (IC50 0.58 mg/mL and 1.83 mM, respectively). The root extracts of H. verticillatum and H.angustisectum were found to be the most effective against acetylcholinesterase (IC50 0.30 and 0.34 mg/mL,respectively). The studied extracts were not active or demonstrated a weak inhibitory effect (%Inh. up to 29.7)towards α-amylase.
Keywords:
Heracleum species / furanocoumarins / antioxidants / acetylcholinesterase inhibition / antidiabetic activity
Source:
Chemistry and Biodiversity, 2019, 16, 4, e1800672-
Publisher:
  • Willey
Funding / projects:
  • TUBITAK, Project No. 116S021
  • Bilateral project between the Bulgarian Academy of Science and the Serbian Academy of Sciences and Arts
Note:
  • http://cer.ihtm.bg.ac.rs/handle/123456789/2869

DOI: 10.1002/cbdv.201800672

ISSN: 1612-1872; 1612-1880 (Online)

WoS: 000467184500017

Scopus: 2-s2.0-85063580781
[ Google Scholar ]
12
5
URI
https://cer.ihtm.bg.ac.rs/handle/123456789/2869
https://cer.ihtm.bg.ac.rs/handle/123456789/2899
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
IHTM
TY  - JOUR
AU  - Ozek, Gulmira
AU  - Yur, Suleyman
AU  - Goger, Fatih
AU  - Ozek, Temel
AU  - Anđelković, Boban D.
AU  - Gođevac, Dejan
AU  - Sofrenić, Ivana
AU  - Aneva, Ina
AU  - Todorova, Milka
AU  - Trendafilova, Antoaneta
PY  - 2019
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2869
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2899
AB  - Hexane extracts of Heracleum verticillatum, H. sibiricum, H. angustisectum, and H. ternatum were studied fortheir furanocoumarin content antioxidant potential and acetylcholinesterase and α-amylase inhibitory activities.Quantification of the furanocoumarins was performed by 1H-NMR. Pimpinellin was found to be the maincomponent in the roots of all studied species. Bergapten and imperatorin were the major compounds in thefruits of H. sibiricum and H. verticillatum, respectively, while byakangelicol dominated in H. angustisectum and H.ternatum fruits. The leaf and fruit extracts of H. angustisectum demonstrated the highest DPPH radical scavengingactivity and TEAC (IC50 0.58 mg/mL and 1.83 mM, respectively). The root extracts of H. verticillatum and H.angustisectum were found to be the most effective against acetylcholinesterase (IC50 0.30 and 0.34 mg/mL,respectively). The studied extracts were not active or demonstrated a weak inhibitory effect (%Inh. up to 29.7)towards α-amylase.
PB  - Willey
T2  - Chemistry and Biodiversity
T1  - Furanocoumarin Content, Antioxidant Activity, and Inhibitory Potential of Heracleum verticillatum, Heracleum sibiricum, Heracleum angustisectum, and Heracleum ternatum Extracts against Enzymes Involved in Alzheimer’s Disease and Type II Diabetes
VL  - 16
IS  - 4
SP  - e1800672
DO  - 10.1002/cbdv.201800672
ER  - 
@article{
author = "Ozek, Gulmira and Yur, Suleyman and Goger, Fatih and Ozek, Temel and Anđelković, Boban D. and Gođevac, Dejan and Sofrenić, Ivana and Aneva, Ina and Todorova, Milka and Trendafilova, Antoaneta",
year = "2019",
abstract = "Hexane extracts of Heracleum verticillatum, H. sibiricum, H. angustisectum, and H. ternatum were studied fortheir furanocoumarin content antioxidant potential and acetylcholinesterase and α-amylase inhibitory activities.Quantification of the furanocoumarins was performed by 1H-NMR. Pimpinellin was found to be the maincomponent in the roots of all studied species. Bergapten and imperatorin were the major compounds in thefruits of H. sibiricum and H. verticillatum, respectively, while byakangelicol dominated in H. angustisectum and H.ternatum fruits. The leaf and fruit extracts of H. angustisectum demonstrated the highest DPPH radical scavengingactivity and TEAC (IC50 0.58 mg/mL and 1.83 mM, respectively). The root extracts of H. verticillatum and H.angustisectum were found to be the most effective against acetylcholinesterase (IC50 0.30 and 0.34 mg/mL,respectively). The studied extracts were not active or demonstrated a weak inhibitory effect (%Inh. up to 29.7)towards α-amylase.",
publisher = "Willey",
journal = "Chemistry and Biodiversity",
title = "Furanocoumarin Content, Antioxidant Activity, and Inhibitory Potential of Heracleum verticillatum, Heracleum sibiricum, Heracleum angustisectum, and Heracleum ternatum Extracts against Enzymes Involved in Alzheimer’s Disease and Type II Diabetes",
volume = "16",
number = "4",
pages = "e1800672",
doi = "10.1002/cbdv.201800672"
}
Ozek, G., Yur, S., Goger, F., Ozek, T., Anđelković, B. D., Gođevac, D., Sofrenić, I., Aneva, I., Todorova, M.,& Trendafilova, A.. (2019). Furanocoumarin Content, Antioxidant Activity, and Inhibitory Potential of Heracleum verticillatum, Heracleum sibiricum, Heracleum angustisectum, and Heracleum ternatum Extracts against Enzymes Involved in Alzheimer’s Disease and Type II Diabetes. in Chemistry and Biodiversity
Willey., 16(4), e1800672.
https://doi.org/10.1002/cbdv.201800672
Ozek G, Yur S, Goger F, Ozek T, Anđelković BD, Gođevac D, Sofrenić I, Aneva I, Todorova M, Trendafilova A. Furanocoumarin Content, Antioxidant Activity, and Inhibitory Potential of Heracleum verticillatum, Heracleum sibiricum, Heracleum angustisectum, and Heracleum ternatum Extracts against Enzymes Involved in Alzheimer’s Disease and Type II Diabetes. in Chemistry and Biodiversity. 2019;16(4):e1800672.
doi:10.1002/cbdv.201800672 .
Ozek, Gulmira, Yur, Suleyman, Goger, Fatih, Ozek, Temel, Anđelković, Boban D., Gođevac, Dejan, Sofrenić, Ivana, Aneva, Ina, Todorova, Milka, Trendafilova, Antoaneta, "Furanocoumarin Content, Antioxidant Activity, and Inhibitory Potential of Heracleum verticillatum, Heracleum sibiricum, Heracleum angustisectum, and Heracleum ternatum Extracts against Enzymes Involved in Alzheimer’s Disease and Type II Diabetes" in Chemistry and Biodiversity, 16, no. 4 (2019):e1800672,
https://doi.org/10.1002/cbdv.201800672 . .

Related items

Showing items related by title, author, creator and subject.

  • Furanocoumarin Content, Antioxidant Activity, and Inhibitory Potential of Heracleum verticillatum, Heracleum sibiricum, Heracleum angustisectum, and Heracleum ternatum Extracts against Enzymes Involved in Alzheimer’s Disease and Type II Diabetes 

    Ozek, Gulmira; Yur, Suleyman; Goger, Fatih; Ozek, Temel; Anđelković, Boban D.; Gođevac, Dejan; Sofrenić, Ivana; Aneva, Ina; Todorova, Milka; Trendafilova, Antoaneta (Willey, 2019)
  • Heracleum orphanidis: chemical characterisation, and comparative evaluation of antioxidant and antimicrobial activities with specific interest in the influence on Pseudomonas aeruginosa PAO1 

    Mileski, Ksenija S; Ciric, Ana D; Trifunović, Snežana; Ristic, Mihailo S; Soković, Marina; Matevski, Vlado S; Tešević, Vele; Jadranin, Milka; Marin, Petar D.; Dzamic, Ana M (Royal Soc Chemistry, Cambridge, 2016)
  • Antibacterial Activity of the Essential Oil of Heracleum sibiricum 

    Miladinovic, Dragoljub L.; Ilic, Budimir S.; Mihajilov-Krstev, Tatjana M.; Nikolic, Dejan M.; Cvetković, Olga; Marković, Marija S.; Miladinovic, Ljiljana C. (Natural Product Incorporation, 2013)

DSpace software copyright © 2002-2015  DuraSpace
About CeR – Central Repository | Send Feedback

re3dataOpenAIRERCUB
 

 

All of DSpaceInstitutions/communitiesAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About CeR – Central Repository | Send Feedback

re3dataOpenAIRERCUB