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Furanocoumarin Content, Antioxidant Activity, and Inhibitory Potential of Heracleum verticillatum, Heracleum sibiricum, Heracleum angustisectum, and Heracleum ternatum Extracts against Enzymes Involved in Alzheimer’s Disease and Type II Diabetes

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2019
10.1002@cbdv.201800672.pdf (4.395Mb)
Authors
Ozek, Gulmira
Yur, Suleyman
Goger, Fatih
Ozek, Temel
Anđelković, Boban D.
Gođevac, Dejan
Sofrenić, Ivana
Aneva, Ina
Todorova, Milka
Trendafilova, Antoaneta
Article (Accepted Version)
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Abstract
Hexane extracts of Heracleum verticillatum, H. sibiricum, H. angustisectum, and H. ternatum were studied fortheir furanocoumarin content antioxidant potential and acetylcholinesterase and α-amylase inhibitory activities.Quantification of the furanocoumarins was performed by 1H-NMR. Pimpinellin was found to be the maincomponent in the roots of all studied species. Bergapten and imperatorin were the major compounds in thefruits of H. sibiricum and H. verticillatum, respectively, while byakangelicol dominated in H. angustisectum and H.ternatum fruits. The leaf and fruit extracts of H. angustisectum demonstrated the highest DPPH radical scavengingactivity and TEAC (IC50 0.58 mg/mL and 1.83 mM, respectively). The root extracts of H. verticillatum and H.angustisectum were found to be the most effective against acetylcholinesterase (IC50 0.30 and 0.34 mg/mL,respectively). The studied extracts were not active or demonstrated a weak inhibitory effect (%Inh. up to 29.7)towards α-amylase.
Keywords:
Heracleum species / furanocoumarins / antioxidants / acetylcholinesterase inhibition / antidiabetic activity
Source:
Chemistry and Biodiversity, 2019, 16, 4, e1800672-
Publisher:
  • Willey
Projects:
  • TUBITAK, Project No. 116S021
  • Bilateral project between the Bulgarian Academy of Science and the Serbian Academy of Sciences and Arts
Note:
  • http://cer.ihtm.bg.ac.rs/handle/123456789/2869

DOI: 10.1002/cbdv.201800672

ISSN: 1612-1872; 1612-1880 (Online)

WoS: 000467184500017

Scopus: 2-s2.0-85063580781
[ Google Scholar ]
1
URI
http://cer.ihtm.bg.ac.rs/handle/123456789/2869
http://cer.ihtm.bg.ac.rs/handle/123456789/2899
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  • Radovi istraživača / Researchers' publications
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