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Furanocoumarin Content, Antioxidant Activity, and Inhibitory Potential of Heracleum verticillatum, Heracleum sibiricum, Heracleum angustisectum, and Heracleum ternatum Extracts against Enzymes Involved in Alzheimer’s Disease and Type II Diabetes
dc.creator | Ozek, Gulmira | |
dc.creator | Yur, Suleyman | |
dc.creator | Goger, Fatih | |
dc.creator | Ozek, Temel | |
dc.creator | Anđelković, Boban D. | |
dc.creator | Gođevac, Dejan | |
dc.creator | Sofrenić, Ivana | |
dc.creator | Aneva, Ina | |
dc.creator | Todorova, Milka | |
dc.creator | Trendafilova, Antoaneta | |
dc.date.accessioned | 2019-05-13T08:32:19Z | |
dc.date.available | 2019-05-13T08:32:19Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 1612-1872 | |
dc.identifier.issn | 1612-1880 (Online) | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/2869 | |
dc.description.abstract | Hexane extracts of Heracleum verticillatum, H. sibiricum, H. angustisectum, and H. ternatum were studied for their furanocoumarin content antioxidant potential and acetylcholinesterase and α-amylase inhibitory activities. Quantification of the furanocoumarins was performed by 1H-NMR. Pimpinellin was found to be the main component in the roots of all studied species. Bergapten and imperatorin were the major compounds in the fruits of H. sibiricum and H. verticillatum, respectively, while byakangelicol dominated in H. angustisectum and H. ternatum fruits. The leaf and fruit extracts of H. angustisectum demonstrated the highest DPPH radical scavenging activity and TEAC (IC50 0.58 mg/mL and 1.83 mM, respectively). The root extracts of H. verticillatum and H.angustisectum were found to be the most effective against acetylcholinesterase (IC50 0.30 and 0.34 mg/mL, respectively). The studied extracts were not active or demonstrated a weak inhibitory effect (%Inh. up to 29.7) towards α-amylase. | en |
dc.language.iso | en | sr |
dc.publisher | Willey | sr |
dc.relation | TUBITAK, Project No. 116S021 | sr |
dc.relation | Bilateral project between the Bulgarian Academy of Sciences and the Serbian Academy of Sciences and Arts | sr |
dc.rights | restrictedAccess | sr |
dc.source | Chemistry and Biodiversity | sr |
dc.subject | Heracleum species | sr |
dc.subject | furanocoumarins | sr |
dc.subject | antioxidants | sr |
dc.subject | acetylcholinesterase inhibition | sr |
dc.subject | antidiabetic activity | sr |
dc.title | Furanocoumarin Content, Antioxidant Activity, and Inhibitory Potential of Heracleum verticillatum, Heracleum sibiricum, Heracleum angustisectum, and Heracleum ternatum Extracts against Enzymes Involved in Alzheimer’s Disease and Type II Diabetes | en |
dc.type | article | sr |
dc.rights.license | ARR | sr |
dcterms.abstract | Трендафилова, Aнтоанета; Озек, Гулмира; Yур, Сулеyман; Гогер, Фатих; Озек, Темел; Aнђелковић, Бобан Д.; Гођевац, Дејан; Софренић, Ивана; Aнева, Ина; Тодорова, Милка; | |
dc.citation.volume | 16 | |
dc.citation.issue | 4 | |
dc.citation.spage | e1800672 | |
dc.citation.rank | M22~ | |
dc.description.other | The peer-reviewed version: [http://cer.ihtm.bg.ac.rs/handle/123456789/2899] | |
dc.identifier.doi | 10.1002/cbdv.201800672 | |
dc.identifier.scopus | 2-s2.0-85063580781 | |
dc.identifier.wos | 000467184500017 | |
dc.type.version | publishedVersion | sr |