Show simple item record

dc.creatorOzek, Gulmira
dc.creatorYur, Suleyman
dc.creatorGoger, Fatih
dc.creatorOzek, Temel
dc.creatorAnđelković, Boban D.
dc.creatorGođevac, Dejan
dc.creatorSofrenić, Ivana
dc.creatorAneva, Ina
dc.creatorTodorova, Milka
dc.creatorTrendafilova, Antoaneta
dc.date.accessioned2019-05-13T08:32:19Z
dc.date.available2019-05-13T08:32:19Z
dc.date.issued2019
dc.identifier.issn1612-1872
dc.identifier.issn1612-1880 (Online)
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/2869
dc.description.abstractHexane extracts of Heracleum verticillatum, H. sibiricum, H. angustisectum, and H. ternatum were studied for their furanocoumarin content antioxidant potential and acetylcholinesterase and α-amylase inhibitory activities. Quantification of the furanocoumarins was performed by 1H-NMR. Pimpinellin was found to be the main component in the roots of all studied species. Bergapten and imperatorin were the major compounds in the fruits of H. sibiricum and H. verticillatum, respectively, while byakangelicol dominated in H. angustisectum and H. ternatum fruits. The leaf and fruit extracts of H. angustisectum demonstrated the highest DPPH radical scavenging activity and TEAC (IC50 0.58 mg/mL and 1.83 mM, respectively). The root extracts of H. verticillatum and H.angustisectum were found to be the most effective against acetylcholinesterase (IC50 0.30 and 0.34 mg/mL, respectively). The studied extracts were not active or demonstrated a weak inhibitory effect (%Inh. up to 29.7) towards α-amylase.en
dc.language.isoensr
dc.publisherWilleysr
dc.relationTUBITAK, Project No. 116S021sr
dc.relationBilateral project between the Bulgarian Academy of Sciences and the Serbian Academy of Sciences and Artssr
dc.rightsrestrictedAccesssr
dc.sourceChemistry and Biodiversitysr
dc.subjectHeracleum speciessr
dc.subjectfuranocoumarinssr
dc.subjectantioxidantssr
dc.subjectacetylcholinesterase inhibitionsr
dc.subjectantidiabetic activitysr
dc.titleFuranocoumarin Content, Antioxidant Activity, and Inhibitory Potential of Heracleum verticillatum, Heracleum sibiricum, Heracleum angustisectum, and Heracleum ternatum Extracts against Enzymes Involved in Alzheimer’s Disease and Type II Diabetesen
dc.typearticlesr
dc.rights.licenseARRsr
dcterms.abstractТрендафилова, Aнтоанета; Озек, Гулмира; Yур, Сулеyман; Гогер, Фатих; Озек, Темел; Aнђелковић, Бобан Д.; Гођевац, Дејан; Софренић, Ивана; Aнева, Ина; Тодорова, Милка;
dc.citation.volume16
dc.citation.issue4
dc.citation.spagee1800672
dc.citation.rankM22~
dc.description.otherThe peer-reviewed version: [http://cer.ihtm.bg.ac.rs/handle/123456789/2899]
dc.identifier.doi10.1002/cbdv.201800672
dc.identifier.scopus2-s2.0-85063580781
dc.identifier.wos000467184500017
dc.type.versionpublishedVersionsr


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record