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A novel lectin from the sponge Haliclona cratera: isolation, characterization and biological activity
dc.creator | Pajic, I | |
dc.creator | Kljajic, Z | |
dc.creator | Dogović, Nikola | |
dc.creator | Sladić, Dušan | |
dc.creator | Juranić, Zorica | |
dc.creator | Gašić, Miroslav J. | |
dc.date.accessioned | 2019-05-02T13:47:47Z | |
dc.date.available | 2019-05-02T13:47:47Z | |
dc.date.issued | 2002 | |
dc.identifier.issn | 1532-0456 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/2837 | |
dc.description.abstract | A lectin from the Adriatic sponge Haliclona cratera was purified by ion-exchange and gel chromatography The molecular mass of the lectin is approximately 29 kDa. Purified lectin is rich in hydrophobic and basic amino acids and has an isoelectric point at pH 8.6. H. cratera lectin is relatively heat- and pH-stable. It agglutinates native and trypsinized, papainized and neuraminidase-treated human A, B, O, AB and sheep erythrocytes, and the hemagglutinating activity is independent of Ca2+, Mn2+ and Mg2+ ions; D-galactose and N-acetyl-D-galactosamine are found to be moderate inhibitors of the activity. H. cratera lectin displays cytotoxic effect on HeLa and FemX cells and weak mitogenic effect on human T-lymphocytes pretreated with phytohemagglutinin (PHA). (C) 2002 Elsevier Science Inc. All rights reserved. | en |
dc.publisher | Elsevier Science Inc, New York | |
dc.rights | restrictedAccess | |
dc.source | Comparative Biochemistry and Physiology. C: Toxicology and Pharmacology | |
dc.subject | sponge | en |
dc.subject | Haliclona cratera | en |
dc.subject | lectin | en |
dc.subject | purification | en |
dc.subject | isolation | en |
dc.subject | stability | en |
dc.subject | cytotoxicity | en |
dc.title | A novel lectin from the sponge Haliclona cratera: isolation, characterization and biological activity | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Јураниц, З; Гасиц, МЈ; Пајиц, И; Кљајиц, З; Договић, Никола; Сладић, Душан; | |
dc.citation.volume | 132 | |
dc.citation.issue | 2 | |
dc.citation.spage | 213 | |
dc.citation.epage | 221 | |
dc.citation.other | 132(2): 213-221 | |
dc.citation.rank | M22 | |
dc.identifier.pmid | 12106898 | |
dc.identifier.doi | 10.1016/S1532-0456(02)00068-6 | |
dc.identifier.scopus | 2-s2.0-0035996841 | |
dc.identifier.wos | 000177257300010 | |
dc.type.version | publishedVersion | en |