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dc.creatorŠukalović, Vladimir
dc.creatorRoglić, Goran
dc.creatorHusinec, Suren
dc.creatorKostić Rajačić, Slađana
dc.creatorAndrić, Deana
dc.creatorŠoškić, Vukić
dc.date.accessioned2019-05-02T10:20:12Z
dc.date.available2019-05-02T10:20:12Z
dc.date.issued2003
dc.identifier.issn0365-6233
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/2827
dc.description.abstractSeveral tertiary 2-phenylethyl, 2-(1-naphthyl)ethyl and 2-(2-naphthyl)ethyl amines were synthesized and their binding affinities for dopamine D(1), D(2) and serotonin 5-HT(1A) receptors evaluated in radioligand binding assays. All compounds were inactive in D(1) dopamine radioligand binding assay. The 2-(1-naphthyl)ethyl analogues expressed a low but significant binding affinity for the D(2) and moderate one for the 5-HT(1A) receptor subtypes. Most of the remaining compounds expressed binding affinity at the 5-HT(1A) receptor subtype but were inactive in D(2) receptor binding assay. Based on these results and considering the chemical characteristics of the compounds synthesized and evaluated for dopaminergic and serotonergic activity throughout the present study it can be concluded that hydrophobic type of interaction (stacking or edge-to-face) plays a significant role in the formation of receptor-ligand complexes of 2-(1-naphthyl)ethyl amines. This structural motive can be applied to design and synthesize new, more potent dopaminergic/serotonergic ligands by slight chemical modifications.en
dc.publisherWiley-Blackwell, Malden
dc.rightsrestrictedAccess
dc.sourceArchiv der Pharmazie
dc.subjectD(2) dopaminergic activityen
dc.subject5-HT(1A) serotonergic activityen
dc.titleD(2) dopaminergic and 5-HT(1A) serotonergic activity of 2-(1-naphthyl)ethyl- and 2-(2-naphthyl)ethyl aminesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractРоглић, Горан; Костић Рајачић, Слађана; Хусинец, С; Сукаловиц, В; Соскиц, В; Aндрић, Деана;
dc.citation.volume336
dc.citation.issue11
dc.citation.spage514
dc.citation.epage522
dc.citation.other336(11): 514-522
dc.citation.rankM23
dc.identifier.pmid14639744
dc.identifier.doi10.1002/ardp.200300776
dc.identifier.rcubKon_1495
dc.identifier.scopus2-s2.0-0347478007
dc.identifier.wos000187229900004
dc.type.versionpublishedVersionen


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