Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential
Само за регистроване кориснике
2004
Аутори
Tomić, MirkoKundaković, M
Butorović, B
Janać, B
Andrić, Deana

Roglić, Goran

Ignjatović, D
Kostić Rajačić, Slađana

Чланак у часопису (Објављена верзија)

Elsevier
Метаподаци
Приказ свих података о документуАпстракт
Six active compounds, among previously synthesized and screened arylpiperazines, were selected and evaluated for the binding affinity to rat dopamine, serotonin and α 1 receptors. Two compounds with benztriazole group had a 5-HT 2A /D 2 binding ratio characteristic for atypical neuroleptics (>1, pK i values). Compound 2, 5-{2-[4-(2,3-dimethyl-phenyl)-piperazin-1-yl]ethyl}1H-benzotriazole, expressed clozapine-like in vitro binding profile at D 2 , 5-HT 2A and α1 receptors and a higher affinity for 5-HT 1A receptors than clozapine. Also, it exhibited the noncataleptic behavioural pattern of atypical antipsychotics and antagonized d-amphetamine-induced hyperlocomotion in rats. © 2004 Elsevier Ltd. All rights reserved.
Кључне речи:
Arylpiperazine / Dopamine receptors / Serotonin receptorsИзвор:
Bioorganic and Medicinal Chemistry Letters, 2004, 14, 16, 4263-4266Издавач:
- Elsevier
Финансирање / пројекти:
- Ministry for Science, Technology and Development of Serbia, grants #1704 and #1698
DOI: 10.1016/j.bmcl.2004.06.005
ISSN: 0960-894X
PubMed: 15261283
WoS: 000222923300029
Scopus: 2-s2.0-3142691095
Институција/група
IHTMTY - JOUR AU - Tomić, Mirko AU - Kundaković, M AU - Butorović, B AU - Janać, B AU - Andrić, Deana AU - Roglić, Goran AU - Ignjatović, D AU - Kostić Rajačić, Slađana PY - 2004 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/2820 AB - Six active compounds, among previously synthesized and screened arylpiperazines, were selected and evaluated for the binding affinity to rat dopamine, serotonin and α 1 receptors. Two compounds with benztriazole group had a 5-HT 2A /D 2 binding ratio characteristic for atypical neuroleptics (>1, pK i values). Compound 2, 5-{2-[4-(2,3-dimethyl-phenyl)-piperazin-1-yl]ethyl}1H-benzotriazole, expressed clozapine-like in vitro binding profile at D 2 , 5-HT 2A and α1 receptors and a higher affinity for 5-HT 1A receptors than clozapine. Also, it exhibited the noncataleptic behavioural pattern of atypical antipsychotics and antagonized d-amphetamine-induced hyperlocomotion in rats. © 2004 Elsevier Ltd. All rights reserved. PB - Elsevier T2 - Bioorganic and Medicinal Chemistry Letters T1 - Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential VL - 14 IS - 16 SP - 4263 EP - 4266 DO - 10.1016/j.bmcl.2004.06.005 ER -
@article{ author = "Tomić, Mirko and Kundaković, M and Butorović, B and Janać, B and Andrić, Deana and Roglić, Goran and Ignjatović, D and Kostić Rajačić, Slađana", year = "2004", abstract = "Six active compounds, among previously synthesized and screened arylpiperazines, were selected and evaluated for the binding affinity to rat dopamine, serotonin and α 1 receptors. Two compounds with benztriazole group had a 5-HT 2A /D 2 binding ratio characteristic for atypical neuroleptics (>1, pK i values). Compound 2, 5-{2-[4-(2,3-dimethyl-phenyl)-piperazin-1-yl]ethyl}1H-benzotriazole, expressed clozapine-like in vitro binding profile at D 2 , 5-HT 2A and α1 receptors and a higher affinity for 5-HT 1A receptors than clozapine. Also, it exhibited the noncataleptic behavioural pattern of atypical antipsychotics and antagonized d-amphetamine-induced hyperlocomotion in rats. © 2004 Elsevier Ltd. All rights reserved.", publisher = "Elsevier", journal = "Bioorganic and Medicinal Chemistry Letters", title = "Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential", volume = "14", number = "16", pages = "4263-4266", doi = "10.1016/j.bmcl.2004.06.005" }
Tomić, M., Kundaković, M., Butorović, B., Janać, B., Andrić, D., Roglić, G., Ignjatović, D.,& Kostić Rajačić, S.. (2004). Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential. in Bioorganic and Medicinal Chemistry Letters Elsevier., 14(16), 4263-4266. https://doi.org/10.1016/j.bmcl.2004.06.005
Tomić M, Kundaković M, Butorović B, Janać B, Andrić D, Roglić G, Ignjatović D, Kostić Rajačić S. Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential. in Bioorganic and Medicinal Chemistry Letters. 2004;14(16):4263-4266. doi:10.1016/j.bmcl.2004.06.005 .
Tomić, Mirko, Kundaković, M, Butorović, B, Janać, B, Andrić, Deana, Roglić, Goran, Ignjatović, D, Kostić Rajačić, Slađana, "Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential" in Bioorganic and Medicinal Chemistry Letters, 14, no. 16 (2004):4263-4266, https://doi.org/10.1016/j.bmcl.2004.06.005 . .