Flavones and sesquiterpene lactones from Achillea atrata subsp, multifida: Antimicrobial activity
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1999
Authors
Aljančić, IvanaVajs, Vlatka
Menković, Nebojša
Karadžić, Ivanka

Juranić, Nenad
Milosavljević, Slobodan

Macura, Slobodan

Article (Published version)

American Chemical Society and American Society of Pharmacognosy
Metadata
Show full item recordAbstract
Four flavones (1-4) and nine sesquiterpene lactones (5-13), one of them (5) a new compound, were isolated from the aerial parts of Achillea atrata L. subsp, multifida. Although the crude extract demonstrated in vitro inhibitory activity against Candida albicans and Bacillus subtilis, all isolated flavones were active against B. subtilis. Flavones 1, 2, and 3 were also active against C. albicans, while 1 and 3 exhibited activity against E. coli, as well. None of the tested lactones (7, 9, 12, and 13) showed any antimicrobial activity.
Keywords:
Achillea atrata / antibacterial activity / antibiotic agent / antifungal activity / article / Bacillus subtilis / Candida albicans / drug conformation / drug determination / drug isolation / Escherichia coli / nonhuman / structure activity relation / antifungal agent / apigenin / centuareidin / santin / unclassified drug / Bacillus subtilis / Candida albicans / Escherichia coliSource:
Journal of Natural Products, 1999, 62, 6, 909-911Publisher:
- American Chemical Society
DOI: 10.1021/np980536m
ISSN: 0163-3864
PubMed: 10395518