Flavones and sesquiterpene lactones from Achillea atrata subsp, multifida: Antimicrobial activity

Aljančić, Ivana; Vajs, Vlatka; Menković, Nebojša; Karadžić, Ivanka; Juranić, Nenad; Milosavljević, Slobodan; Macura, Slobodan

doi:10.1021/np980536m

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1999

Authors

Aljančić, Ivana
Vajs, Vlatka
Menković, Nebojša
Karadžić, Ivanka

Juranić, Nenad
Milosavljević, Slobodan

Macura, Slobodan

Article (Published version)

American Chemical Society and American Society of Pharmacognosy

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Abstract

Four flavones (1-4) and nine sesquiterpene lactones (5-13), one of them (5) a new compound, were isolated from the aerial parts of Achillea atrata L. subsp, multifida. Although the crude extract demonstrated in vitro inhibitory activity against Candida albicans and Bacillus subtilis, all isolated flavones were active against B. subtilis. Flavones 1, 2, and 3 were also active against C. albicans, while 1 and 3 exhibited activity against E. coli, as well. None of the tested lactones (7, 9, 12, and 13) showed any antimicrobial activity.

Keywords:

Achillea atrata / antibacterial activity / antibiotic agent / antifungal activity / article / Bacillus subtilis / Candida albicans / drug conformation / drug determination / drug isolation / Escherichia coli / nonhuman / structure activity relation / antifungal agent / apigenin / centuareidin / santin / unclassified drug / Bacillus subtilis / Candida albicans / Escherichia coli

Source:
Journal of Natural Products, 1999, 62, 6, 909-911

Publisher:

American Chemical Society (ACS)

DOI: 10.1021/np980536m

ISSN: 0163-3864

PubMed: 10395518

WoS: 000081140100027

Scopus: 2-s2.0-0345517307

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TY  - JOUR
AU  - Aljančić, Ivana
AU  - Vajs, Vlatka
AU  - Menković, Nebojša
AU  - Karadžić, Ivanka
AU  - Juranić, Nenad
AU  - Milosavljević, Slobodan
AU  - Macura, Slobodan
PY  - 1999
UR  - http://cer.ihtm.bg.ac.rs/handle/123456789/2809
AB  - Four flavones (1-4) and nine sesquiterpene lactones (5-13), one of them (5) a new compound, were isolated from the aerial parts of Achillea atrata L. subsp, multifida. Although the crude extract demonstrated in vitro inhibitory activity against Candida albicans and Bacillus subtilis, all isolated flavones were active against B. subtilis. Flavones 1, 2, and 3 were also active against C. albicans, while 1 and 3 exhibited activity against E. coli, as well. None of the tested lactones (7, 9, 12, and 13) showed any antimicrobial activity.
PB  - American Chemical Society (ACS)
T2  - Journal of Natural Products
T1  - Flavones and sesquiterpene lactones from Achillea atrata subsp, multifida: Antimicrobial activity
VL  - 62
IS  - 6
SP  - 909
EP  - 911
DO  - 10.1021/np980536m
ER  -

@article{
author = "Aljančić, Ivana and Vajs, Vlatka and Menković, Nebojša and Karadžić, Ivanka and Juranić, Nenad and Milosavljević, Slobodan and Macura, Slobodan",
year = "1999",
url = "http://cer.ihtm.bg.ac.rs/handle/123456789/2809",
abstract = "Four flavones (1-4) and nine sesquiterpene lactones (5-13), one of them (5) a new compound, were isolated from the aerial parts of Achillea atrata L. subsp, multifida. Although the crude extract demonstrated in vitro inhibitory activity against Candida albicans and Bacillus subtilis, all isolated flavones were active against B. subtilis. Flavones 1, 2, and 3 were also active against C. albicans, while 1 and 3 exhibited activity against E. coli, as well. None of the tested lactones (7, 9, 12, and 13) showed any antimicrobial activity.",
publisher = "American Chemical Society (ACS)",
journal = "Journal of Natural Products",
title = "Flavones and sesquiterpene lactones from Achillea atrata subsp, multifida: Antimicrobial activity",
volume = "62",
number = "6",
pages = "909-911",
doi = "10.1021/np980536m"
}

Aljančić, I., Vajs, V., Menković, N., Karadžić, I., Juranić, N., Milosavljević, S.,& Macura, S. (1999). Flavones and sesquiterpene lactones from Achillea atrata subsp, multifida: Antimicrobial activity.
Journal of Natural Products
American Chemical Society (ACS)., 62(6), 909-911.
https://doi.org/10.1021/np980536m

Aljančić I, Vajs V, Menković N, Karadžić I, Juranić N, Milosavljević S, Macura S. Flavones and sesquiterpene lactones from Achillea atrata subsp, multifida: Antimicrobial activity. Journal of Natural Products. 1999;62(6):909-911

Aljančić Ivana, Vajs Vlatka, Menković Nebojša, Karadžić Ivanka, Juranić Nenad, Milosavljević Slobodan, Macura Slobodan, "Flavones and sesquiterpene lactones from Achillea atrata subsp, multifida: Antimicrobial activity" Journal of Natural Products, 62, no. 6 (1999):909-911,
https://doi.org/10.1021/np980536m .