Semisynthesis of Taxol (R): an improved procedure far the isolation of 10-deacetylbaccatin III
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From the needles of domestic yew, (Taxus baccata), 10-deacetylbaccatin III (10-DAB) call be isolated in quantities of up to 297 mg per kg of fresh needles. Additional quantities of 10-DAB call be obtained from the extract by NaBH4 mediated reductive hydrolysis of baccatin esters. A four-step procedure converts 10-DAB into taxol in 58% overall yield.
Keywords:
anti-tumor agents / taxol / natural products / semisynthesisSource:
Journal of the Serbian Chemical Society, 1999, 64, 9, 497-503Publisher:
- Serbian Chemical Soc, Belgrade
DOI: 10.2298/JSC9909497S
ISSN: 0352-5139
WoS: 000082557600001
Scopus: 2-s2.0-0038929346
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IHTMTY - JOUR AU - Saičić, Radomir N. AU - Matović, Radomir AU - Čeković, Živorad PY - 1999 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/2777 AB - From the needles of domestic yew, (Taxus baccata), 10-deacetylbaccatin III (10-DAB) call be isolated in quantities of up to 297 mg per kg of fresh needles. Additional quantities of 10-DAB call be obtained from the extract by NaBH4 mediated reductive hydrolysis of baccatin esters. A four-step procedure converts 10-DAB into taxol in 58% overall yield. PB - Serbian Chemical Soc, Belgrade T2 - Journal of the Serbian Chemical Society T1 - Semisynthesis of Taxol (R): an improved procedure far the isolation of 10-deacetylbaccatin III VL - 64 IS - 9 SP - 497 EP - 503 DO - 10.2298/JSC9909497S ER -
@article{ author = "Saičić, Radomir N. and Matović, Radomir and Čeković, Živorad", year = "1999", abstract = "From the needles of domestic yew, (Taxus baccata), 10-deacetylbaccatin III (10-DAB) call be isolated in quantities of up to 297 mg per kg of fresh needles. Additional quantities of 10-DAB call be obtained from the extract by NaBH4 mediated reductive hydrolysis of baccatin esters. A four-step procedure converts 10-DAB into taxol in 58% overall yield.", publisher = "Serbian Chemical Soc, Belgrade", journal = "Journal of the Serbian Chemical Society", title = "Semisynthesis of Taxol (R): an improved procedure far the isolation of 10-deacetylbaccatin III", volume = "64", number = "9", pages = "497-503", doi = "10.2298/JSC9909497S" }
Saičić, R. N., Matović, R.,& Čeković, Ž.. (1999). Semisynthesis of Taxol (R): an improved procedure far the isolation of 10-deacetylbaccatin III. in Journal of the Serbian Chemical Society Serbian Chemical Soc, Belgrade., 64(9), 497-503. https://doi.org/10.2298/JSC9909497S
Saičić RN, Matović R, Čeković Ž. Semisynthesis of Taxol (R): an improved procedure far the isolation of 10-deacetylbaccatin III. in Journal of the Serbian Chemical Society. 1999;64(9):497-503. doi:10.2298/JSC9909497S .
Saičić, Radomir N., Matović, Radomir, Čeković, Živorad, "Semisynthesis of Taxol (R): an improved procedure far the isolation of 10-deacetylbaccatin III" in Journal of the Serbian Chemical Society, 64, no. 9 (1999):497-503, https://doi.org/10.2298/JSC9909497S . .