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Semisynthesis of Taxol (R): an improved procedure far the isolation of 10-deacetylbaccatin III

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1999
JSCS9-01.pdf (1.953Mb)
Authors
Saičić, Radomir N.
Matović, Radomir
Čeković, Živorad
Article (Published version)
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Abstract
From the needles of domestic yew, (Taxus baccata), 10-deacetylbaccatin III (10-DAB) call be isolated in quantities of up to 297 mg per kg of fresh needles. Additional quantities of 10-DAB call be obtained from the extract by NaBH4 mediated reductive hydrolysis of baccatin esters. A four-step procedure converts 10-DAB into taxol in 58% overall yield.
Keywords:
anti-tumor agents / taxol / natural products / semisynthesis
Source:
Journal of the Serbian Chemical Society, 1999, 64, 9, 497-503
Publisher:
  • Serbian Chemical Soc, Belgrade

DOI: 10.2298/JSC9909497S

ISSN: 0352-5139

WoS: 000082557600001

Scopus: 2-s2.0-0038929346
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URI
http://cer.ihtm.bg.ac.rs/handle/123456789/2777
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IHTM

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