From the needles of domestic yew, (Taxus baccata), 10-deacetylbaccatin III (10-DAB) call be isolated in quantities of up to 297 mg per kg of fresh needles. Additional quantities of 10-DAB call be obtained from the extract by NaBH4 mediated reductive hydrolysis of baccatin esters. A four-step procedure converts 10-DAB into taxol in 58% overall yield.
TY - JOUR
AU - Saičić, Radomir N.
AU - Matović, Radomir
AU - Čeković, Živorad
PY - 1999
UR - http://cer.ihtm.bg.ac.rs/handle/123456789/2777
AB - From the needles of domestic yew, (Taxus baccata), 10-deacetylbaccatin III (10-DAB) call be isolated in quantities of up to 297 mg per kg of fresh needles. Additional quantities of 10-DAB call be obtained from the extract by NaBH4 mediated reductive hydrolysis of baccatin esters. A four-step procedure converts 10-DAB into taxol in 58% overall yield.
PB - Serbian Chemical Soc, Belgrade
T2 - Journal of the Serbian Chemical Society
T1 - Semisynthesis of Taxol (R): an improved procedure far the isolation of 10-deacetylbaccatin III
VL - 64
IS - 9
SP - 497
EP - 503
DO - 10.2298/JSC9909497S
ER -
@article{
author = "Saičić, Radomir N. and Matović, Radomir and Čeković, Živorad",
year = "1999",
url = "http://cer.ihtm.bg.ac.rs/handle/123456789/2777",
abstract = "From the needles of domestic yew, (Taxus baccata), 10-deacetylbaccatin III (10-DAB) call be isolated in quantities of up to 297 mg per kg of fresh needles. Additional quantities of 10-DAB call be obtained from the extract by NaBH4 mediated reductive hydrolysis of baccatin esters. A four-step procedure converts 10-DAB into taxol in 58% overall yield.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Semisynthesis of Taxol (R): an improved procedure far the isolation of 10-deacetylbaccatin III",
volume = "64",
number = "9",
pages = "497-503",
doi = "10.2298/JSC9909497S"
}
Saičić, R. N., Matović, R.,& Čeković, Ž. (1999). Semisynthesis of Taxol (R): an improved procedure far the isolation of 10-deacetylbaccatin III.
Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 64(9), 497-503.
https://doi.org/10.2298/JSC9909497S
Saičić RN, Matović R, Čeković Ž. Semisynthesis of Taxol (R): an improved procedure far the isolation of 10-deacetylbaccatin III. Journal of the Serbian Chemical Society. 1999;64(9):497-503
Saičić Radomir N., Matović Radomir, Čeković Živorad, "Semisynthesis of Taxol (R): an improved procedure far the isolation of 10-deacetylbaccatin III" Journal of the Serbian Chemical Society, 64, no. 9 (1999):497-503,
https://doi.org/10.2298/JSC9909497S .
