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Synthesis, biology, and modeling of a C-4 carbonyl C,D-seco-taxoid
dc.creator | Ferjančić, Zorana | |
dc.creator | Matović, Radomir | |
dc.creator | Čeković, Živorad | |
dc.creator | Jiang, Yi | |
dc.creator | Snyder, James P. | |
dc.creator | Trajković, Vladimir | |
dc.creator | Saičić, Radomir N. | |
dc.date.accessioned | 2019-04-29T08:17:19Z | |
dc.date.available | 2019-04-29T08:17:19Z | |
dc.date.issued | 2006 | |
dc.identifier.issn | 0040-4020 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/2772 | |
dc.description.abstract | A C,D-seco-paclitaxel derivative 26 was prepared from taxine and tested for biological activity. Chemical reactivity of the seco-compounds proved to be substantially modified, with respects to taxoids. The corresponding C,D-seco-taxoid does not show tubulin stabilizing activity or cytotoxicity. Explanation of these observations based on molecular modeling is provided. (c) 2006 Elsevier Ltd. All rights reserved. | en |
dc.publisher | Oxford : Pergamon-Elsevier Science Ltd | |
dc.rights | restrictedAccess | |
dc.source | Tetrahedron | |
dc.subject | taxane antitumor agents | en |
dc.subject | radicals and radical reactions | en |
dc.subject | medium sized rings | en |
dc.subject | natural products | en |
dc.subject | molecular modeling | en |
dc.title | Synthesis, biology, and modeling of a C-4 carbonyl C,D-seco-taxoid | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Саичић, Радомир Н.; Ферјанчић, Зорана; Матовић, Радомир; Чековић, Живорад; Јианг, Yи; Снyдер, Јамес П.; Трајковић, Владимир С.; | |
dc.citation.volume | 62 | |
dc.citation.issue | 36 | |
dc.citation.spage | 8503 | |
dc.citation.epage | 8514 | |
dc.citation.other | 62(36): 8503-8514 | |
dc.citation.rank | M22 | |
dc.identifier.doi | 10.1016/j.tet.2006.06.080 | |
dc.identifier.scopus | 2-s2.0-33746306276 | |
dc.identifier.wos | 000240125700010 | |
dc.type.version | publishedVersion | en |