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dc.creatorFerjančić, Zorana
dc.creatorMatović, Radomir
dc.creatorČeković, Živorad
dc.creatorJiang, Yi
dc.creatorSnyder, James P.
dc.creatorTrajković, Vladimir
dc.creatorSaičić, Radomir N.
dc.date.accessioned2019-04-29T08:17:19Z
dc.date.available2019-04-29T08:17:19Z
dc.date.issued2006
dc.identifier.issn0040-4020
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/2772
dc.description.abstractA C,D-seco-paclitaxel derivative 26 was prepared from taxine and tested for biological activity. Chemical reactivity of the seco-compounds proved to be substantially modified, with respects to taxoids. The corresponding C,D-seco-taxoid does not show tubulin stabilizing activity or cytotoxicity. Explanation of these observations based on molecular modeling is provided. (c) 2006 Elsevier Ltd. All rights reserved.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.rightsrestrictedAccess
dc.sourceTetrahedron
dc.subjecttaxane antitumor agentsen
dc.subjectradicals and radical reactionsen
dc.subjectmedium sized ringsen
dc.subjectnatural productsen
dc.subjectmolecular modelingen
dc.titleSynthesis, biology, and modeling of a C-4 carbonyl C,D-seco-taxoiden
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСаичић, Радомир Н.; Ферјанчић, Зорана; Матовић, Радомир; Чековић, Живорад; Јианг, Yи; Снyдер, Јамес П.; Трајковић, Владимир С.;
dc.citation.volume62
dc.citation.issue36
dc.citation.spage8503
dc.citation.epage8514
dc.citation.other62(36): 8503-8514
dc.citation.rankM22
dc.identifier.doi10.1016/j.tet.2006.06.080
dc.identifier.rcubKon_1751
dc.identifier.scopus2-s2.0-33746306276
dc.identifier.wos000240125700010
dc.type.versionpublishedVersionen


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