As part of our ongoing project of new acetylcholinesterase inhibitors from lower marine and terrestrial species, a phytochemical investigation was conducted on a foliose lichen, Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), from Bosnia and Herzegovina. The study led to the isolation of a mixture of acetylated depsidones which showed a moderate activity (0.5 mu g) in the acetylcholinesterase inhibition test on Thin-layer chromatography plate. Our results indicate for the first time the significance of depsidones, highly specific metabolites from lichen species, in searching for these inhibitors which still represent the best drugs currently available for the management of Alzheimer's disease.
TY - JOUR
AU - Pejin, Boris
AU - Tommonaro, Giuseppina
AU - Iodice, Carmine
AU - Tešević, Vele
AU - Vajs, Vlatka
PY - 2012
UR - http://cer.ihtm.bg.ac.rs/handle/123456789/2742
AB - As part of our ongoing project of new acetylcholinesterase inhibitors from lower marine and terrestrial species, a phytochemical investigation was conducted on a foliose lichen, Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), from Bosnia and Herzegovina. The study led to the isolation of a mixture of acetylated depsidones which showed a moderate activity (0.5 mu g) in the acetylcholinesterase inhibition test on Thin-layer chromatography plate. Our results indicate for the first time the significance of depsidones, highly specific metabolites from lichen species, in searching for these inhibitors which still represent the best drugs currently available for the management of Alzheimer's disease.
PB - Taylor & Francis Ltd, Abingdon
T2 - Natural Product Research
T1 - Acetylcholinesterase inhibition activity of acetylated depsidones from Lobaria pulmonaria
VL - 26
IS - 17
SP - 1634
EP - 1637
DO - 10.1080/14786419.2011.585989
ER -
@article{
author = "Pejin, Boris and Tommonaro, Giuseppina and Iodice, Carmine and Tešević, Vele and Vajs, Vlatka",
year = "2012",
url = "http://cer.ihtm.bg.ac.rs/handle/123456789/2742",
abstract = "As part of our ongoing project of new acetylcholinesterase inhibitors from lower marine and terrestrial species, a phytochemical investigation was conducted on a foliose lichen, Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), from Bosnia and Herzegovina. The study led to the isolation of a mixture of acetylated depsidones which showed a moderate activity (0.5 mu g) in the acetylcholinesterase inhibition test on Thin-layer chromatography plate. Our results indicate for the first time the significance of depsidones, highly specific metabolites from lichen species, in searching for these inhibitors which still represent the best drugs currently available for the management of Alzheimer's disease.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Acetylcholinesterase inhibition activity of acetylated depsidones from Lobaria pulmonaria",
volume = "26",
number = "17",
pages = "1634-1637",
doi = "10.1080/14786419.2011.585989"
}
Pejin, B., Tommonaro, G., Iodice, C., Tešević, V.,& Vajs, V. (2012). Acetylcholinesterase inhibition activity of acetylated depsidones from Lobaria pulmonaria.
Natural Product Research
Taylor & Francis Ltd, Abingdon., 26(17), 1634-1637.
https://doi.org/10.1080/14786419.2011.585989
Pejin B, Tommonaro G, Iodice C, Tešević V, Vajs V. Acetylcholinesterase inhibition activity of acetylated depsidones from Lobaria pulmonaria. Natural Product Research. 2012;26(17):1634-1637
Pejin Boris, Tommonaro Giuseppina, Iodice Carmine, Tešević Vele, Vajs Vlatka, "Acetylcholinesterase inhibition activity of acetylated depsidones from Lobaria pulmonaria" Natural Product Research, 26, no. 17 (2012):1634-1637,
https://doi.org/10.1080/14786419.2011.585989 .
