Acetylcholinesterase inhibition activity of acetylated depsidones from Lobaria pulmonaria
Abstract
As part of our ongoing project of new acetylcholinesterase inhibitors from lower marine and terrestrial species, a phytochemical investigation was conducted on a foliose lichen, Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), from Bosnia and Herzegovina. The study led to the isolation of a mixture of acetylated depsidones which showed a moderate activity (0.5 mu g) in the acetylcholinesterase inhibition test on Thin-layer chromatography plate. Our results indicate for the first time the significance of depsidones, highly specific metabolites from lichen species, in searching for these inhibitors which still represent the best drugs currently available for the management of Alzheimer's disease.
Keywords:
lichen / Lobaria pulmonaria / depsidones / acetylcholinesterase inhibition activity / Alzheimer's diseaseSource:
Natural Product Research, 2012, 26, 17, 1634-1637Publisher:
- Taylor & Francis Ltd, Abingdon
Funding / projects:
- Sekundarni metaboliti samoniklih, lekovitih biljaka: izolovanje, karakterizacija i biloška aktivnost (RS-142053)
DOI: 10.1080/14786419.2011.585989
ISSN: 1478-6419
PubMed: 21985528
WoS: 000307350800011
Scopus: 2-s2.0-84865190526
Collections
Institution/Community
IHTMTY - JOUR AU - Pejin, Boris AU - Tommonaro, Giuseppina AU - Iodice, Carmine AU - Tešević, Vele AU - Vajs, Vlatka PY - 2012 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/2742 AB - As part of our ongoing project of new acetylcholinesterase inhibitors from lower marine and terrestrial species, a phytochemical investigation was conducted on a foliose lichen, Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), from Bosnia and Herzegovina. The study led to the isolation of a mixture of acetylated depsidones which showed a moderate activity (0.5 mu g) in the acetylcholinesterase inhibition test on Thin-layer chromatography plate. Our results indicate for the first time the significance of depsidones, highly specific metabolites from lichen species, in searching for these inhibitors which still represent the best drugs currently available for the management of Alzheimer's disease. PB - Taylor & Francis Ltd, Abingdon T2 - Natural Product Research T1 - Acetylcholinesterase inhibition activity of acetylated depsidones from Lobaria pulmonaria VL - 26 IS - 17 SP - 1634 EP - 1637 DO - 10.1080/14786419.2011.585989 ER -
@article{ author = "Pejin, Boris and Tommonaro, Giuseppina and Iodice, Carmine and Tešević, Vele and Vajs, Vlatka", year = "2012", abstract = "As part of our ongoing project of new acetylcholinesterase inhibitors from lower marine and terrestrial species, a phytochemical investigation was conducted on a foliose lichen, Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), from Bosnia and Herzegovina. The study led to the isolation of a mixture of acetylated depsidones which showed a moderate activity (0.5 mu g) in the acetylcholinesterase inhibition test on Thin-layer chromatography plate. Our results indicate for the first time the significance of depsidones, highly specific metabolites from lichen species, in searching for these inhibitors which still represent the best drugs currently available for the management of Alzheimer's disease.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "Natural Product Research", title = "Acetylcholinesterase inhibition activity of acetylated depsidones from Lobaria pulmonaria", volume = "26", number = "17", pages = "1634-1637", doi = "10.1080/14786419.2011.585989" }
Pejin, B., Tommonaro, G., Iodice, C., Tešević, V.,& Vajs, V.. (2012). Acetylcholinesterase inhibition activity of acetylated depsidones from Lobaria pulmonaria. in Natural Product Research Taylor & Francis Ltd, Abingdon., 26(17), 1634-1637. https://doi.org/10.1080/14786419.2011.585989
Pejin B, Tommonaro G, Iodice C, Tešević V, Vajs V. Acetylcholinesterase inhibition activity of acetylated depsidones from Lobaria pulmonaria. in Natural Product Research. 2012;26(17):1634-1637. doi:10.1080/14786419.2011.585989 .
Pejin, Boris, Tommonaro, Giuseppina, Iodice, Carmine, Tešević, Vele, Vajs, Vlatka, "Acetylcholinesterase inhibition activity of acetylated depsidones from Lobaria pulmonaria" in Natural Product Research, 26, no. 17 (2012):1634-1637, https://doi.org/10.1080/14786419.2011.585989 . .