A new prenylated flavanonol named seselinonol (1) was isolated from the roots of Seseli annuum, together with the well-known biologically active polyacetylenes falcarinol (2) and falcarindiol (3), and the prenylated furanocoumarin phellopterin (4). Its structure was elucidated by extensive spectroscopic analysis, including HR-ESI-MS, ID- and 2D-NMR. Seselinonol and phellopterin were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (CBMN) assay. The new compound exerted a beneficial effect by decreasing DNA damage of human lymphocytes.
TY - JOUR
AU - Vučković, Ivan
AU - Vajs, Vlatka
AU - Stanković, Miroslava
AU - Tešević, Vele
AU - Milosavljević, Slobodan
PY - 2010
UR - http://cer.ihtm.bg.ac.rs/handle/123456789/2732
AB - A new prenylated flavanonol named seselinonol (1) was isolated from the roots of Seseli annuum, together with the well-known biologically active polyacetylenes falcarinol (2) and falcarindiol (3), and the prenylated furanocoumarin phellopterin (4). Its structure was elucidated by extensive spectroscopic analysis, including HR-ESI-MS, ID- and 2D-NMR. Seselinonol and phellopterin were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (CBMN) assay. The new compound exerted a beneficial effect by decreasing DNA damage of human lymphocytes.
PB - Wiley-V C H Verlag Gmbh, Weinheim
T2 - Chemistry and Biodiversity
T1 - A New Prenylated Flavanonol from Seseli annuum Roots Showing Protective Effect on Human Lymphocytes DNA
VL - 7
IS - 3
SP - 698
EP - 704
DO - 10.1002/cbdv.200900067
ER -
@article{
author = "Vučković, Ivan and Vajs, Vlatka and Stanković, Miroslava and Tešević, Vele and Milosavljević, Slobodan",
year = "2010",
url = "http://cer.ihtm.bg.ac.rs/handle/123456789/2732",
abstract = "A new prenylated flavanonol named seselinonol (1) was isolated from the roots of Seseli annuum, together with the well-known biologically active polyacetylenes falcarinol (2) and falcarindiol (3), and the prenylated furanocoumarin phellopterin (4). Its structure was elucidated by extensive spectroscopic analysis, including HR-ESI-MS, ID- and 2D-NMR. Seselinonol and phellopterin were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (CBMN) assay. The new compound exerted a beneficial effect by decreasing DNA damage of human lymphocytes.",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "Chemistry and Biodiversity",
title = "A New Prenylated Flavanonol from Seseli annuum Roots Showing Protective Effect on Human Lymphocytes DNA",
volume = "7",
number = "3",
pages = "698-704",
doi = "10.1002/cbdv.200900067"
}
Vučković, I., Vajs, V., Stanković, M., Tešević, V.,& Milosavljević, S. (2010). A New Prenylated Flavanonol from Seseli annuum Roots Showing Protective Effect on Human Lymphocytes DNA.
Chemistry and Biodiversity
Wiley-V C H Verlag Gmbh, Weinheim., 7(3), 698-704.
https://doi.org/10.1002/cbdv.200900067
Vučković I, Vajs V, Stanković M, Tešević V, Milosavljević S. A New Prenylated Flavanonol from Seseli annuum Roots Showing Protective Effect on Human Lymphocytes DNA. Chemistry and Biodiversity. 2010;7(3):698-704
Vučković Ivan, Vajs Vlatka, Stanković Miroslava, Tešević Vele, Milosavljević Slobodan, "A New Prenylated Flavanonol from Seseli annuum Roots Showing Protective Effect on Human Lymphocytes DNA" Chemistry and Biodiversity, 7, no. 3 (2010):698-704,
https://doi.org/10.1002/cbdv.200900067 .
