A New Prenylated Flavanonol from Seseli annuum Roots Showing Protective Effect on Human Lymphocytes DNA
Abstract
A new prenylated flavanonol named seselinonol (1) was isolated from the roots of Seseli annuum, together with the well-known biologically active polyacetylenes falcarinol (2) and falcarindiol (3), and the prenylated furanocoumarin phellopterin (4). Its structure was elucidated by extensive spectroscopic analysis, including HR-ESI-MS, ID- and 2D-NMR. Seselinonol and phellopterin were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (CBMN) assay. The new compound exerted a beneficial effect by decreasing DNA damage of human lymphocytes.
Source:
Chemistry and Biodiversity, 2010, 7, 3, 698-704Publisher:
- Wiley-V C H Verlag Gmbh, Weinheim
Funding / projects:
- Sekundarni metaboliti samoniklih, lekovitih biljaka: izolovanje, karakterizacija i biloška aktivnost (RS-142053)
DOI: 10.1002/cbdv.200900067
ISSN: 1612-1872
PubMed: 20232332
WoS: 000276059600015
Scopus: 2-s2.0-77949728574
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Institution/Community
IHTMTY - JOUR AU - Vučković, Ivan AU - Vajs, Vlatka AU - Stanković, Miroslava AU - Tešević, Vele AU - Milosavljević, Slobodan PY - 2010 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/2732 AB - A new prenylated flavanonol named seselinonol (1) was isolated from the roots of Seseli annuum, together with the well-known biologically active polyacetylenes falcarinol (2) and falcarindiol (3), and the prenylated furanocoumarin phellopterin (4). Its structure was elucidated by extensive spectroscopic analysis, including HR-ESI-MS, ID- and 2D-NMR. Seselinonol and phellopterin were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (CBMN) assay. The new compound exerted a beneficial effect by decreasing DNA damage of human lymphocytes. PB - Wiley-V C H Verlag Gmbh, Weinheim T2 - Chemistry and Biodiversity T1 - A New Prenylated Flavanonol from Seseli annuum Roots Showing Protective Effect on Human Lymphocytes DNA VL - 7 IS - 3 SP - 698 EP - 704 DO - 10.1002/cbdv.200900067 ER -
@article{ author = "Vučković, Ivan and Vajs, Vlatka and Stanković, Miroslava and Tešević, Vele and Milosavljević, Slobodan", year = "2010", abstract = "A new prenylated flavanonol named seselinonol (1) was isolated from the roots of Seseli annuum, together with the well-known biologically active polyacetylenes falcarinol (2) and falcarindiol (3), and the prenylated furanocoumarin phellopterin (4). Its structure was elucidated by extensive spectroscopic analysis, including HR-ESI-MS, ID- and 2D-NMR. Seselinonol and phellopterin were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (CBMN) assay. The new compound exerted a beneficial effect by decreasing DNA damage of human lymphocytes.", publisher = "Wiley-V C H Verlag Gmbh, Weinheim", journal = "Chemistry and Biodiversity", title = "A New Prenylated Flavanonol from Seseli annuum Roots Showing Protective Effect on Human Lymphocytes DNA", volume = "7", number = "3", pages = "698-704", doi = "10.1002/cbdv.200900067" }
Vučković, I., Vajs, V., Stanković, M., Tešević, V.,& Milosavljević, S.. (2010). A New Prenylated Flavanonol from Seseli annuum Roots Showing Protective Effect on Human Lymphocytes DNA. in Chemistry and Biodiversity Wiley-V C H Verlag Gmbh, Weinheim., 7(3), 698-704. https://doi.org/10.1002/cbdv.200900067
Vučković I, Vajs V, Stanković M, Tešević V, Milosavljević S. A New Prenylated Flavanonol from Seseli annuum Roots Showing Protective Effect on Human Lymphocytes DNA. in Chemistry and Biodiversity. 2010;7(3):698-704. doi:10.1002/cbdv.200900067 .
Vučković, Ivan, Vajs, Vlatka, Stanković, Miroslava, Tešević, Vele, Milosavljević, Slobodan, "A New Prenylated Flavanonol from Seseli annuum Roots Showing Protective Effect on Human Lymphocytes DNA" in Chemistry and Biodiversity, 7, no. 3 (2010):698-704, https://doi.org/10.1002/cbdv.200900067 . .