A new prenylated flavanonol named seselinonol (1) was isolated from the roots of Seseli annuum, together with the well-known biologically active polyacetylenes falcarinol (2) and falcarindiol (3), and the prenylated furanocoumarin phellopterin (4). Its structure was elucidated by extensive spectroscopic analysis, including HR-ESI-MS, ID- and 2D-NMR. Seselinonol and phellopterin were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (CBMN) assay. The new compound exerted a beneficial effect by decreasing DNA damage of human lymphocytes.
TY - JOUR
AU - Vučković, Ivan
AU - Vajs, Vlatka
AU - Stanković, Miroslava
AU - Tešević, Vele
AU - Milosavljević, Slobodan
PY - 2010
UR - https://cer.ihtm.bg.ac.rs/handle/123456789/2732
AB - A new prenylated flavanonol named seselinonol (1) was isolated from the roots of Seseli annuum, together with the well-known biologically active polyacetylenes falcarinol (2) and falcarindiol (3), and the prenylated furanocoumarin phellopterin (4). Its structure was elucidated by extensive spectroscopic analysis, including HR-ESI-MS, ID- and 2D-NMR. Seselinonol and phellopterin were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (CBMN) assay. The new compound exerted a beneficial effect by decreasing DNA damage of human lymphocytes.
PB - Wiley-V C H Verlag Gmbh, Weinheim
T2 - Chemistry and Biodiversity
T1 - A New Prenylated Flavanonol from Seseli annuum Roots Showing Protective Effect on Human Lymphocytes DNA
VL - 7
IS - 3
SP - 698
EP - 704
DO - 10.1002/cbdv.200900067
ER -
@article{
author = "Vučković, Ivan and Vajs, Vlatka and Stanković, Miroslava and Tešević, Vele and Milosavljević, Slobodan",
year = "2010",
abstract = "A new prenylated flavanonol named seselinonol (1) was isolated from the roots of Seseli annuum, together with the well-known biologically active polyacetylenes falcarinol (2) and falcarindiol (3), and the prenylated furanocoumarin phellopterin (4). Its structure was elucidated by extensive spectroscopic analysis, including HR-ESI-MS, ID- and 2D-NMR. Seselinonol and phellopterin were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (CBMN) assay. The new compound exerted a beneficial effect by decreasing DNA damage of human lymphocytes.",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "Chemistry and Biodiversity",
title = "A New Prenylated Flavanonol from Seseli annuum Roots Showing Protective Effect on Human Lymphocytes DNA",
volume = "7",
number = "3",
pages = "698-704",
doi = "10.1002/cbdv.200900067"
}
Vučković, I., Vajs, V., Stanković, M., Tešević, V.,& Milosavljević, S.. (2010). A New Prenylated Flavanonol from Seseli annuum Roots Showing Protective Effect on Human Lymphocytes DNA. in Chemistry and Biodiversity
Wiley-V C H Verlag Gmbh, Weinheim., 7(3), 698-704.
https://doi.org/10.1002/cbdv.200900067
Vučković I, Vajs V, Stanković M, Tešević V, Milosavljević S. A New Prenylated Flavanonol from Seseli annuum Roots Showing Protective Effect on Human Lymphocytes DNA. in Chemistry and Biodiversity. 2010;7(3):698-704.
doi:10.1002/cbdv.200900067 .
Vučković, Ivan, Vajs, Vlatka, Stanković, Miroslava, Tešević, Vele, Milosavljević, Slobodan, "A New Prenylated Flavanonol from Seseli annuum Roots Showing Protective Effect on Human Lymphocytes DNA" in Chemistry and Biodiversity, 7, no. 3 (2010):698-704,
https://doi.org/10.1002/cbdv.200900067 . .
