dc.creator | Trifunović, Snežana | |
dc.creator | Vajs, Vlatka | |
dc.creator | Juranić, Zorica | |
dc.creator | Žižak, Željko | |
dc.creator | Tešević, Vele | |
dc.creator | Macura, Slobodan | |
dc.creator | Milosavljević, Slobodan | |
dc.date.accessioned | 2019-04-26T21:32:08Z | |
dc.date.available | 2019-04-26T21:32:08Z | |
dc.date.issued | 2006 | |
dc.identifier.issn | 0031-9422 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/2713 | |
dc.description.abstract | Examination of the aerial parts of Achillea clavennae afforded eight guaianolides (1-8), three bisabolenes (9 11), four flavonols (12-15), sesamin (lignan) and isofraxidin (coumarin). The structures of the new compounds (2, 4, 5, 7 and 10) were determined by spectroscopic methods. The antiproliferative action of 2, 8, 9 and 12 were tested to HeLa, K562 and Fem-X human cancer cell lines. Guaianolides 2 (9 alpha-acetoxyartecanin) and 8 (apressin) showed significant cytotoxic effects to all tested lines and inducumenone (9) exhibited a moderate activity. The most active was flavonol centaureidin (12), already known as cytotoxic compound. (c) 2006 Elsevier Ltd. All rights reserved. | en |
dc.publisher | Oxford : Pergamon-Elsevier Science Ltd | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/142053/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/145006/RS// | |
dc.rights | restrictedAccess | |
dc.source | Phytochemistry | |
dc.subject | Achillea clavennae | en |
dc.subject | Asteraceae | en |
dc.subject | guaianolides | en |
dc.subject | bisabolenes | en |
dc.subject | flavonoids | en |
dc.subject | cytotoxicity | en |
dc.title | Cytotoxic constituents of Achillea clavennae from Montenegro | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Тешевић, Веле; Зизак, Зељко; Мацура, Слободан; Милосављевић, Слободан М.; Трифуновић, Снежана С.; Јураниц, Зорица; Вајс, Влатка; | |
dc.citation.volume | 67 | |
dc.citation.issue | 9 | |
dc.citation.spage | 887 | |
dc.citation.epage | 893 | |
dc.citation.other | 67(9): 887-893 | |
dc.citation.rank | M21 | |
dc.identifier.pmid | 16616262 | |
dc.identifier.doi | 10.1016/j.phytochem.2006.02.026 | |
dc.identifier.scopus | 2-s2.0-33646072788 | |
dc.identifier.wos | 000237600300007 | |
dc.type.version | publishedVersion | en |