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dc.creatorTrifunović, Snežana
dc.creatorVajs, Vlatka
dc.creatorJuranić, Zorica
dc.creatorŽižak, Željko
dc.creatorTešević, Vele
dc.creatorMacura, Slobodan
dc.creatorMilosavljević, Slobodan
dc.date.accessioned2019-04-26T21:32:08Z
dc.date.available2019-04-26T21:32:08Z
dc.date.issued2006
dc.identifier.issn0031-9422
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/2713
dc.description.abstractExamination of the aerial parts of Achillea clavennae afforded eight guaianolides (1-8), three bisabolenes (9 11), four flavonols (12-15), sesamin (lignan) and isofraxidin (coumarin). The structures of the new compounds (2, 4, 5, 7 and 10) were determined by spectroscopic methods. The antiproliferative action of 2, 8, 9 and 12 were tested to HeLa, K562 and Fem-X human cancer cell lines. Guaianolides 2 (9 alpha-acetoxyartecanin) and 8 (apressin) showed significant cytotoxic effects to all tested lines and inducumenone (9) exhibited a moderate activity. The most active was flavonol centaureidin (12), already known as cytotoxic compound. (c) 2006 Elsevier Ltd. All rights reserved.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142053/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145006/RS//
dc.rightsrestrictedAccess
dc.sourcePhytochemistry
dc.subjectAchillea clavennaeen
dc.subjectAsteraceaeen
dc.subjectguaianolidesen
dc.subjectbisabolenesen
dc.subjectflavonoidsen
dc.subjectcytotoxicityen
dc.titleCytotoxic constituents of Achillea clavennae from Montenegroen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractТешевић, Веле; Зизак, Зељко; Мацура, Слободан; Милосављевић, Слободан М.; Трифуновић, Снежана С.; Јураниц, Зорица; Вајс, Влатка;
dc.citation.volume67
dc.citation.issue9
dc.citation.spage887
dc.citation.epage893
dc.citation.other67(9): 887-893
dc.citation.rankM21
dc.identifier.pmid16616262
dc.identifier.doi10.1016/j.phytochem.2006.02.026
dc.identifier.scopus2-s2.0-33646072788
dc.identifier.wos000237600300007
dc.type.versionpublishedVersionen


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