Cytotoxic constituents of Achillea clavennae from Montenegro
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2006
Authors
Trifunović, Snežana
Vajs, Vlatka
Juranić, Zorica

Žižak, Željko

Tešević, Vele

Macura, Slobodan

Milosavljević, Slobodan

Article (Published version)

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Show full item recordAbstract
Examination of the aerial parts of Achillea clavennae afforded eight guaianolides (1-8), three bisabolenes (9 11), four flavonols (12-15), sesamin (lignan) and isofraxidin (coumarin). The structures of the new compounds (2, 4, 5, 7 and 10) were determined by spectroscopic methods. The antiproliferative action of 2, 8, 9 and 12 were tested to HeLa, K562 and Fem-X human cancer cell lines. Guaianolides 2 (9 alpha-acetoxyartecanin) and 8 (apressin) showed significant cytotoxic effects to all tested lines and inducumenone (9) exhibited a moderate activity. The most active was flavonol centaureidin (12), already known as cytotoxic compound. (c) 2006 Elsevier Ltd. All rights reserved.
Keywords:
Achillea clavennae / Asteraceae / guaianolides / bisabolenes / flavonoids / cytotoxicitySource:
Phytochemistry, 2006, 67, 9, 887-893Publisher:
- Pergamon-Elsevier Science Ltd, Oxford
Projects:
- Sekundarni metaboliti samoniklih, lekovitih biljaka: izolovanje, karakterizacija i biloška aktivnost (RS-142053)
- Istraživanje dejstava modifikatora biološkog odgovora u fiziološkim i patološkim stanjima (RS-145006)
DOI: 10.1016/j.phytochem.2006.02.026
ISSN: 0031-9422
PubMed: 16616262