Cytotoxic constituents of Achillea clavennae from Montenegro

Trifunović, Snežana; Vajs, Vlatka; Juranić, Zorica; Žižak, Željko; Tešević, Vele; Macura, Slobodan; Milosavljević, Slobodan

doi:10.1016/j.phytochem.2006.02.026

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2006

Authors

Trifunović, Snežana

Vajs, Vlatka
Juranić, Zorica

Žižak, Željko

Tešević, Vele

Macura, Slobodan

Milosavljević, Slobodan

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Abstract

Examination of the aerial parts of Achillea clavennae afforded eight guaianolides (1-8), three bisabolenes (9 11), four flavonols (12-15), sesamin (lignan) and isofraxidin (coumarin). The structures of the new compounds (2, 4, 5, 7 and 10) were determined by spectroscopic methods. The antiproliferative action of 2, 8, 9 and 12 were tested to HeLa, K562 and Fem-X human cancer cell lines. Guaianolides 2 (9 alpha-acetoxyartecanin) and 8 (apressin) showed significant cytotoxic effects to all tested lines and inducumenone (9) exhibited a moderate activity. The most active was flavonol centaureidin (12), already known as cytotoxic compound. (c) 2006 Elsevier Ltd. All rights reserved.

Keywords:

Achillea clavennae / Asteraceae / guaianolides / bisabolenes / flavonoids / cytotoxicity

Source:
Phytochemistry, 2006, 67, 9, 887-893

Publisher:

Pergamon-Elsevier Science Ltd, Oxford

Projects:

DOI: 10.1016/j.phytochem.2006.02.026

ISSN: 0031-9422

PubMed: 16616262

WoS: 000237600300007

Scopus: 2-s2.0-33646072788

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TY  - JOUR
AU  - Trifunović, Snežana
AU  - Vajs, Vlatka
AU  - Juranić, Zorica
AU  - Žižak, Željko
AU  - Tešević, Vele
AU  - Macura, Slobodan
AU  - Milosavljević, Slobodan
PY  - 2006
UR  - http://cer.ihtm.bg.ac.rs/handle/123456789/2713
AB  - Examination of the aerial parts of Achillea clavennae afforded eight guaianolides (1-8), three bisabolenes (9 11), four flavonols (12-15), sesamin (lignan) and isofraxidin (coumarin). The structures of the new compounds (2, 4, 5, 7 and 10) were determined by spectroscopic methods. The antiproliferative action of 2, 8, 9 and 12 were tested to HeLa, K562 and Fem-X human cancer cell lines. Guaianolides 2 (9 alpha-acetoxyartecanin) and 8 (apressin) showed significant cytotoxic effects to all tested lines and inducumenone (9) exhibited a moderate activity. The most active was flavonol centaureidin (12), already known as cytotoxic compound. (c) 2006 Elsevier Ltd. All rights reserved.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Phytochemistry
T1  - Cytotoxic constituents of Achillea clavennae from Montenegro
VL  - 67
IS  - 9
SP  - 887
EP  - 893
DO  - 10.1016/j.phytochem.2006.02.026
ER  -

@article{
author = "Trifunović, Snežana and Vajs, Vlatka and Juranić, Zorica and Žižak, Željko and Tešević, Vele and Macura, Slobodan and Milosavljević, Slobodan",
year = "2006",
url = "http://cer.ihtm.bg.ac.rs/handle/123456789/2713",
abstract = "Examination of the aerial parts of Achillea clavennae afforded eight guaianolides (1-8), three bisabolenes (9 11), four flavonols (12-15), sesamin (lignan) and isofraxidin (coumarin). The structures of the new compounds (2, 4, 5, 7 and 10) were determined by spectroscopic methods. The antiproliferative action of 2, 8, 9 and 12 were tested to HeLa, K562 and Fem-X human cancer cell lines. Guaianolides 2 (9 alpha-acetoxyartecanin) and 8 (apressin) showed significant cytotoxic effects to all tested lines and inducumenone (9) exhibited a moderate activity. The most active was flavonol centaureidin (12), already known as cytotoxic compound. (c) 2006 Elsevier Ltd. All rights reserved.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Phytochemistry",
title = "Cytotoxic constituents of Achillea clavennae from Montenegro",
volume = "67",
number = "9",
pages = "887-893",
doi = "10.1016/j.phytochem.2006.02.026"
}

Trifunović S, Vajs V, Juranić Z, Žižak Ž, Tešević V, Macura S, Milosavljević S. Cytotoxic constituents of Achillea clavennae from Montenegro. Phytochemistry. 2006;67(9):887-893

Trifunović, S., Vajs, V., Juranić, Z., Žižak, Ž., Tešević, V., Macura, S.,& Milosavljević, S. (2006). Cytotoxic constituents of Achillea clavennae from Montenegro.
PhytochemistryPergamon-Elsevier Science Ltd, Oxford., 67(9), 887-893.
https://doi.org/10.1016/j.phytochem.2006.02.026

Trifunović Snežana, Vajs Vlatka, Juranić Zorica, Žižak Željko, Tešević Vele, Macura Slobodan, Milosavljević Slobodan, "Cytotoxic constituents of Achillea clavennae from Montenegro" 67, no. 9 (2006):887-893,
https://doi.org/10.1016/j.phytochem.2006.02.026 .