Synthesis of modified 5,10:8,14-bisfragmentation cholestane derivatives
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Mihailović, Mihailo Lj.Pavlović, Vladimir D.
Bondarenko-Gheorghiu, Lidija
Krstić, Natalija

Dabović, Milan
Lorenc, Ljubinka
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In this paper is described a synthetic pathway to the modified 5, 10:8, 14-bisfragmentation cholestene derivatives 10, 11 and 12, which involves introduction of the Δ8(14)-double bond and 5α-hydroxyl group in the cholestane molecule and subsequent cleavage of the olefinic C(8)-C(14) bond (with ruthenium tetroxide) and C(5)-C(10) bond (with mercuric oxide/iodine or lead tetracetate/iodine).
Keywords:
Lactones / Acetates / secosteroidal macrocyclesSource:
Journal of the Serbian Chemical Society, 1996, 61, 11, 941-946Publisher:
- Serbian Chemical Society